Publication Date:
2015-12-19
Description:
The genomic causes and effects of divergent ecological selection during speciation are still poorly understood. Here we report the discovery and detailed characterization of early-stage adaptive divergence of two cichlid fish ecomorphs in a small (700 meters in diameter) isolated crater lake in Tanzania. The ecomorphs differ in depth preference, male breeding color, body shape, diet, and trophic morphology. With whole-genome sequences of 146 fish, we identified 98 clearly demarcated genomic "islands" of high differentiation and demonstrated the association of genotypes across these islands with divergent mate preferences. The islands contain candidate adaptive genes enriched for functions in sensory perception (including rhodopsin and other twilight-vision-associated genes), hormone signaling, and morphogenesis. Our study suggests mechanisms and genomic regions that may play a role in the closely related mega-radiation of Lake Malawi.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700518/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700518/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malinsky, Milan -- Challis, Richard J -- Tyers, Alexandra M -- Schiffels, Stephan -- Terai, Yohey -- Ngatunga, Benjamin P -- Miska, Eric A -- Durbin, Richard -- Genner, Martin J -- Turner, George F -- 097677/Z/11/Z/Wellcome Trust/United Kingdom -- WT098051/Wellcome Trust/United Kingdom -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2015 Dec 18;350(6267):1493-8. doi: 10.1126/science.aac9927.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QN, UK. ; School of Biological Sciences, Bangor University, Bangor, Gwynedd LL57 2UW, UK. ; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. ; Department of Evolutionary Studies of Biosystems, SOKENDAI, Kanagawa 240-0193, Japan. ; Tanzania Fisheries Research Institute, Box 9750, Dar es Salaam, Tanzania. ; School of Biological Sciences, Life Sciences Building, 24 Tyndall Avenue, University of Bristol, Bristol BS8 1TQ, UK. george.turner@bangor.ac.uk m.genner@bristol.ac.uk. ; School of Biological Sciences, Bangor University, Bangor, Gwynedd LL57 2UW, UK. george.turner@bangor.ac.uk m.genner@bristol.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26680190" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological/*genetics
;
Animals
;
Cichlids/classification/*genetics/*physiology
;
*Genomic Islands
;
Lakes
;
*Mating Preference, Animal
;
Phylogeny
;
Polymorphism, Single Nucleotide
;
Species Specificity
;
Tanzania
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink