ISSN:
1573-9171
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Conclusions 1. A hydroximic acid chloride, viz., 4-chloroximino-3-imidazoline 3-oxide, reacts with nitrogen-containing nucleophilic reagents to give amidoxime derivatives. The reaction with tert-butylhydroxylamine leads to an N-hydroxyamidoxime, the oxidation of which made it possible to preparatively isolate an amidoxime N-oxyl radical, viz., 4-(N-oxyl-N-tert-butylcarboxamidoximino)-1,2,2,5,5-pentamethyl-3-imidazoline 3-oxide. 2. Oxidation of the radical gives a nitroso nitrone, and alkylation gives only an O-alkylation product (an ether amidoxime N-oxyl), whereas the similarly constructed amidoxime reacts to give both an O-alkylation product (an ether amidoxime) and an N-alkylation product (a nitrone).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00950152
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