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  • 1
    Electronic Resource
    Electronic Resource
    The microscopic examination of the apollo-11 and -12 sample and the quest for life forms
    Amsterdam : Elsevier
    Journal of Ultrasructure Research 35 (1971), S. 403-410 
    Details
    ISSN: 0022-5320
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-5320(71)80001-1
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Ultrastructure of Pseudomonas saccharophila at early and late log phase of growth. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Description of the fine structure of Pseudomonas saccarophila at the early log phase and the late log phase of growth, such as shown by electron microscopy with the aid of various techniques of preparation. The observations reported suggested that, under the experimental conditions applied, P. saccharophila multiplies by the method of constrictive division.
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 109; Feb. 197
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Results of examination of the calvarium, brain, and meninges (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Tissue reactions were found around the monitor (dosimeter) assemblies that had been implanted beneath the scalp of the five pocket mice that flew on Apollo XVII. Mitosis in the dentate gyrus of the hippocampal formation was considerably reduced in comparison with that in control animals. Otherwise the brain tissue as well as the meninges in the flight animals appeared unaltered. Since the animals were exposed primarily to high Z-high energy (HZE) cosmic-ray particles at the lower end of the high LET spectrum, the lack of changes in the brain cannot be taken as evidence that the brain will suffer no damage from the heavier HZE particles on prolonged manned missions.
    Keywords: LIFE SCIENCES (GENERAL)
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    NASA TECHNICAL REPORTS
  • 4
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    Results of ear examination (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: In the five pocket mice flown on Apollo XVII, no evidence was found that the inner ear had been damaged, though poor fixation precluded detailed study. On the other hand, the middle ear cavity was involved in all the mice, hemorrhage having occurred in response to excursions in pressure within the canister that housed the mice during their flight. The same occurred in flight control mice which had been subjected to pressure excursions of much the same magnitude. A greater degree of exudation into air cells and greater leukotaxis were noted in the flight animals than in the control animals. There was no increase in leukocyte population along the paths of the 23 cosmic-ray particles registered in the subscalp dosimeters that traversed the middle ear cavities of the flight mice. The increased exudation and the greater response by leukocytes in the flight mice may have been causally related to the lesions found in their olfactory mucosa but there were no data in support of this possibility.
    Keywords: LIFE SCIENCES (GENERAL)
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  • 5
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    Results of examination of the nasal mucosa (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: The olfactory epithelium, but not the nasal respiratory epithelium, of the four pocket mice (Perognathus longimembris) that survived their flight on Apollo XVII showed both diffuse alterations and numerous disseminated focal lesions. The olfactory mucosa of the mouse that died during flight was also affected, but to a minor degree insofar as could be determined. All this was in contrast to the normal appearance of the olfactory mucosa of the numerous control animals. A number of possible causes were considered: systemic or regional infection; inhaled particulate material (seed dust); by-products from the KO2 bed in aerosol or particulate form; gas contaminants originating in the flight package; volatile substances from the dead mouse; weightlessness; and cosmic ray particle radiation. Where feasible, studies were conducted in an effort to rule in or rule out some of these potentially causative factors. No definitive conclusions were reached as to the cause of the lesions in the flight mice.
    Keywords: LIFE SCIENCES (GENERAL)
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  • 6
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    Cosmic ray particle dosimetry and trajectory tracing (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Five pocket mice (Perognathus longimembris) were flown on Apollo XVII, each with a solid-state (plastic) nuclear track detector implanted beneath its scalp. The subscalp detectors were sensitive to HZE cosmic ray particles with a LET greater than or approximately equal to 0.15 million electron volts per micrometer (MeV/micron). A critical aspect of the dosimetry of the experiment involved tracing individual particle trajectories through each mouse head from particle tracks registered in the individual subscalp detectors, thereby establishing a one-to-one correspondence between a trajectory location in the tissue and the presence or absence of a lesion. The other major aspect was the identification of each registered particle. An average of 16 particles with Z greater than or equal to 6 and 2.2 particles with Z greater than or equal to 20 were found per detector. The track density, 29 tracks/sq cm, when adjusted for detection volume, was in agreement with the photographic emulsion data from an area dosimeter located next to the flight package.
    Keywords: LIFE SCIENCES (GENERAL)
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  • 7
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    Growth and reproduction of microorganisms under extremely alkaline conditions (1974)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Applied Microbiology; 28; Dec. 197
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    NASA TECHNICAL REPORTS
  • 8
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    Ultrastructural changes in tracheal epithelial cells exposed to oxygen (1977)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: White albino rats were sacrificed after 24, 36, 48, 72, and 96 h of exposure to 100% O2 at 1 atm. Tissue was prepared for the scanning electron microscope (SEM) by Critical Point Drying and for the transmission electron microscope (TEM) by plastic embedding. Scanning microscopy showed a loss of microvilli after 48 h of exposure. Cilia appeared relatively normal with SEM, but TEM revealed changes in the outer membrane. In TEM, nonciliated cells appeared swollen and often encroached on the ciliated cells. A heavy mucous blanket remained even after processing. All the changes observed that are induced by oxygen exposure contribute to mucostasis, reducing and/or halting mucociliary clearance.
    Keywords: LIFE SCIENCES (GENERAL)
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  • 9
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    Retinal changes in rats flown on Cosmos 936 - A cosmic ray experiment (1980)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Ten rats, five centrifuged during flight to simulate gravity and five stationary in flight and experiencing hypogravity, orbited the Earth. No differences were noted between flight-stationary and flight-centrifuged animals, but changes were seen between these two groups and ground controls. Morphological alterations were observed comparable to those in the experiment flown on Cosmos 782 and to the retinal cells exposed to high-energy particles at Berkeley. Affected cells in the outer nuclear layer showed swelling, clearing of cytoplasm, and disruption of the membranes. Tissue channels were again found, similar to those seen on 782. After space flight, preliminary data indicated an increase in cell size in montages of the nuclear layer of both groups of flight animals. This experiment shows that weightlessness and environmental conditions other than cosmic radiation do not contribute to the observed damage of retinal cells.
    Keywords: LIFE SCIENCES (GENERAL)
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    NASA TECHNICAL REPORTS
  • 10
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    Modification of a Kowa RC-2 fundus camera for self-photography without the use of mydriatics (1979)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Research on retinal circulation during space flight required the development of a simple technique to provide self monitoring of blood vessel changes in the fundus without the use of mydriatics. A Kowa RC-2 fundus camera was modified for self-photography by the use of a bite plate for positioning and cross hairs for focusing the subject's retina relative to the film plane. Dilation of the pupils without the use of mydriatics was accomplished by dark-adaption of the subject. Pictures were obtained without pupil constriction by the use of a high speed strobe light. This method also has applications for clinical medicine.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Brain Research Bulletin; 4; 1979
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