Publikationsdatum:
1996-04-05
Beschreibung:
Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts[(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in Drosophila melanogaster. In the present study a gene encoding the Drosophila(6-4)photolyase ws cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants. A homolog of the Drosophila (6-4)photolyase gene was also cloned from human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todo, T -- Ryo, H -- Yamamoto, K -- Toh, H -- Inui, T -- Ayaki, H -- Nomura, T -- Ikenaga, M -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):109-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Radiation Biology Center, Kyoto University, Kyoto, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600518" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amino Acid Sequence
;
Animals
;
Cloning, Molecular
;
DNA Repair
;
DNA, Complementary/genetics
;
Deoxyribodipyrimidine Photo-Lyase/*chemistry/genetics/metabolism
;
Drosophila melanogaster/*enzymology/genetics
;
Flavin-Adenine Dinucleotide/metabolism
;
Genes, Insect
;
Humans
;
Light
;
Molecular Sequence Data
;
Photoreceptor Cells, Invertebrate/*chemistry
;
Plant Proteins/*chemistry
;
Recombinant Proteins/chemistry/metabolism
;
Sequence Alignment
;
Ultraviolet Rays
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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