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  • 1
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    Avian persistence in fragmented rainforest (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-09
    Description: What factors determine the persistence of species in fragmented habitats? To address this question, we studied the relative impacts of forest deterioration and fragmentation on bird species in 12 rainforest fragments in Kenya, combining 6 years of individual capture-recapture data with measurements of current captures and museum specimens. Species mobility, as estimated from species-specific dispersal rates, and tolerance to habitat deterioration, as estimated from change in fluctuating asymmetry with increasing habitat disturbance, explained 88% of the variation in patch occupancy among eight forest bird species. Occupancy increased with mobility and with tolerance to deterioration, where both variables contributed equally to this relationship. We conclude that individual-level study, such as of dispersal behavior and phenotypic development, can predict patterns of persistence at the species level. More generally, for conservation tactics to stand a high chance of success, they should include action both within sites, to minimize habitat deterioration, and across landscapes, to maximize dispersal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lens, Luc -- Van Dongen, Stefan -- Norris, Ken -- Githiru, Mwangi -- Matthysen, Erik -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1236-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Antwerp, B-2610 Wilrijk, Belgium. luc.lens@rug.ac.be〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424379" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Birds/anatomy & histology/physiology ; Conservation of Natural Resources ; *Ecosystem ; *Environment ; Kenya ; Logistic Models ; Models, Biological ; Models, Statistical ; Phenotype ; Population Dynamics ; Probability ; Species Specificity ; Tarsus, Animal/anatomy & histology ; *Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-02-18
    Description: MicroRNAs (miRNAs) comprise 1 to 3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. By using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target messenger RNA molecules (mRNAs). Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giraldez, Antonio J -- Mishima, Yuichiro -- Rihel, Jason -- Grocock, Russell J -- Van Dongen, Stijn -- Inoue, Kunio -- Enright, Anton J -- Schier, Alexander F -- New York, N.Y. -- Science. 2006 Apr 7;312(5770):75-9. Epub 2006 Feb 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. giraldez@mcb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16484454" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Adenosine/*metabolism ; Animals ; Embryo, Nonmammalian/*physiology ; *Embryonic Development ; Female ; Gene Expression Profiling ; *Gene Expression Regulation, Developmental ; Genes, Reporter ; Green Fluorescent Proteins/genetics/metabolism ; MicroRNAs/*physiology ; Mutation ; Oligonucleotide Array Sequence Analysis ; Polymers/*metabolism ; Protein Biosynthesis ; RNA Stability ; RNA, Messenger/genetics/*metabolism ; Ribonuclease III/genetics/metabolism ; Transcription, Genetic ; Up-Regulation ; Zebrafish/embryology ; Zygote/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Requirement of bic/microRNA-155 for normal immune function (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-04-28
    Description: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610435/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610435/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rodriguez, Antony -- Vigorito, Elena -- Clare, Simon -- Warren, Madhuri V -- Couttet, Philippe -- Soond, Dalya R -- van Dongen, Stijn -- Grocock, Russell J -- Das, Partha P -- Miska, Eric A -- Vetrie, David -- Okkenhaug, Klaus -- Enright, Anton J -- Dougan, Gordon -- Turner, Martin -- Bradley, Allan -- 077187/Wellcome Trust/United Kingdom -- G117/424/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Apr 27;316(5824):608-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17463290" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Untranslated Regions ; Animals ; B-Lymphocytes/*immunology ; Cytokines/biosynthesis ; Dendritic Cells/*immunology ; Gene Expression Regulation ; Gene Targeting ; Homeostasis ; Immune System/*physiology ; Immunoglobulin G/biosynthesis ; Lung/pathology ; Lung Diseases/immunology/pathology ; Lymphocyte Activation ; Mice ; MicroRNAs/genetics/*physiology ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins c-maf/genetics/physiology ; Salmonella Infections, Animal/immunology ; T-Lymphocytes/*immunology ; Th1 Cells/immunology ; Th2 Cells/immunology ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Large-scale patterns of shell variation in Littorina striata, a planktonic developing periwinkle from Macaronesia (Mollusca: Prosobranchia) (1998)
    Springer
    Marine biology 131 (1998), S. 309-317 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Littorina striata King and Broderip, 1832 is a strictly Macaronesian, intertidal periwinkle with planktonic development. The species displays a high degree of shell variation involving size and sculpture (nodulose vs smooth shells). The present work provides a preliminary account of some aspects of this shell variation on wave-exposed shores over the entire geographical range of the species. Based on morphological patterns observed among other prosobranchs it was predicted that southern specimens of L. littorina should on the average be larger, heavier, more nodulose, and should show more shell repair marks, than northern specimens. These expectations were confirmed for shell size and weight. In contrast, there was no consistent pattern in nodulosity between archipelagos, even though there were differences at much smaller scales. Shell repair marks were more prevalent in northern populations, but this trend was only due to a significant N–S difference among nodulose shells. This is surprising as nodulose shells displayed significantly fewer shell repair marks than smooth shells. These observations were tentatively interpreted as a function of presumed differential N–S patterns of wave action and ambient temperatures. In this context, wave action in Macaronesia seems to increase in the south (contrary to what current theories predict). This atypical situation may confound the interpretation of morphological patterns in L. striata so that firm conclusions cannot be drawn without further experimental work at different spatial scales. Nevertheless, it seems that generalisations about macrogeographic shell morphology patterns, based on interspecific comparisons, are not directly applicable to intraspecific patterns, and may strongly depend on local conditions which make adequate sampling and data treatment very difficult.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050324
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  • 5
    Electronic Resource
    Electronic Resource
    Bootstrap tests for specific hypotheses at single locus inbreeding coefficients (1997)
    Springer
    Genetica 99 (1997), S. 47-58 
    Details
    ISSN: 1573-6857
    Keywords: bootstrap ; F-statistics ; Hardy-Weinberg law ; power ; resampling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Deviations of genotype distribution from Hardy-Weinberg expectations within a (sub)population can give valuable insight into the population structure, and can be quantified by means of F is values. Specific biological and/or genetical hypotheses regarding F is require particular statistical procedures to be able to perform the test with high power. The bootstrap offers a convenient way to test against a broad range of alternative hypotheses. It enables: a) comparison of an observed F is with any expected value between −1 and 1, and b) comparison of two or more observed F is values. However, it fails under numerous situations, and great caution should be taken before applying the bootstrap to estimate confidence intervals of F is. We discuss under which conditions the bootstrap gives reliable results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018390000873
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  • 6
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    How should we bootstrap allozyme data? (1995)
    Springer Nature
    Details
    Publication Date: 1995-04-01
    Print ISSN: 0018-067X
    Electronic ISSN: 1365-2540
    Topics: Biology
    Published by Springer Nature
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  • 7
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    One- and two-sample tests for single-locus inbreeding coefficients using the bootstrap (1995)
    Springer Nature
    Details
    Publication Date: 1995-02-01
    Print ISSN: 0018-067X
    Electronic ISSN: 1365-2540
    Topics: Biology
    Published by Springer Nature
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  • 8
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    Genetic population structure of the winter moth (Operophtera brumata L.) (Lepidoptera, Geometridae) in a fragmented landscape (1998)
    Springer Nature
    Details
    Publication Date: 1998-01-01
    Print ISSN: 0018-067X
    Electronic ISSN: 1365-2540
    Topics: Biology
    Published by Springer Nature
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  • 9
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    Bootstrap tests for specific hypotheses at single locus inbreeding coefficients (1997)
    Springer
    Details
    Publication Date: 1997-02-01
    Print ISSN: 0016-6707
    Electronic ISSN: 1573-6857
    Topics: Biology
    Published by Springer
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  • 10
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    Large-scale patterns of shell variation in Littorina striata , a planktonic developing periwinkle from Macaronesia (Mollusca: Prosobranchia) (1998)
    Springer
    Details
    Publication Date: 1998-05-29
    Print ISSN: 0025-3162
    Electronic ISSN: 1432-1793
    Topics: Biology
    Published by Springer
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