Publication Date:
1992-06-12
Description:
Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ericson, J -- Thor, S -- Edlund, T -- Jessell, T M -- Yamada, T -- New York, N.Y. -- Science. 1992 Jun 12;256(5063):1555-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Umea University, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1350865" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Chick Embryo
;
Embryonic Induction
;
Gene Expression
;
*Genes, Homeobox
;
Immunoenzyme Techniques
;
Motor Neurons/cytology/*physiology
;
Notochord/physiology
;
Spinal Cord/*embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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