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  • 1
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    Racemic X-ray structure of a heterochiral complex [Biochemistry] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-09-12
    Description: Total chemical synthesis was used to prepare the mirror image (D-protein) form of the angiogenic protein vascular endothelial growth factor (VEGF-A). Phage display against D-VEGF-A was used to screen designed libraries based on a unique small protein scaffold in order to identify a high affinity ligand. Chemically synthesized D- and...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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    PAPER CURRENT
  • 2
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    Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-01-19
    Description: The evolutionarily conserved Wnt/Wingless signal transduction pathway directs cell proliferation, cell fate, and cell death during development in metazoans and is inappropriately activated in several types of cancer. The majority of colorectal carcinomas contain truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor, a negative regulator of Wnt/Wingless signaling. Here, we demonstrate that Drosophila Apc homologs also have an activating role in both physiological and ectopic Wingless signaling. The Apc amino terminus is important for its activating function, whereas the beta-catenin binding sites are dispensable. Apc likely promotes Wingless transduction through down-regulation of Axin, a negative regulator of Wingless signaling. Given the evolutionary conservation of APC in Wnt signal transduction, an activating role may also be present in vertebrates with relevance to development and cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takacs, Carter M -- Baird, Jason R -- Hughes, Edward G -- Kent, Sierra S -- Benchabane, Hassina -- Paik, Raehum -- Ahmed, Yashi -- KO8CA078532/CA/NCI NIH HHS/ -- R01 CA105038/CA/NCI NIH HHS/ -- R01CA105038/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Jan 18;319(5861):333-6. doi: 10.1126/science.1151232.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18202290" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis ; Armadillo Domain Proteins/metabolism ; Axin Protein ; Binding Sites ; Cytoskeletal Proteins/chemistry/genetics/*metabolism ; Down-Regulation ; Drosophila/genetics/growth & development/*metabolism ; Drosophila Proteins/chemistry/genetics/*metabolism ; Genes, Insect ; Mutation ; Photoreceptor Cells, Invertebrate/cytology ; Proto-Oncogene Proteins/*metabolism ; *Signal Transduction ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/chemistry/genetics/*metabolism ; Wings, Animal/growth & development/metabolism ; Wnt1 Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Racemic crystallography of a key TB protein [Biochemistry] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-04-08
    Description: Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. Rv1738, a protein from Mycobacterium tuberculosis that is strongly implicated in the onset of nonreplicating persistence, and thereby latent tuberculosis, resisted extensive attempts at crystallization. Chemical synthesis of the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Predetection telemetry analog recording and playback for Pioneer Venus 1978 (1978)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: Prediction telemetry recording and playback capability was implemented in the DSN to meet PV-78 mission requirements. Test data, along with theoretical considerations, gives assurance that the data degradation commitment of 1.5 db will be met, and it is anticipated that in actual performance the design goal of 1.0 db will be met. The major technical problems requiring solution were elimination of image in the OLR and the reduction of analog recorder instabilities. These were solved through the use of single-sideband mixing techniques and the use of newer generation analog recorders.
    Keywords: SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
    Type: The Deep Space Network; p 197-203
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    Viking telecommunication effects of GEOS satellite interference based on testing at the Madrid deep space station (1976)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: In support of the ongoing NASA-European Space Agency (ESA) effort to understand and control possible interference between missions, testing was conducted at the Madrid Deep Space Station from July 1975 to February 1976 to characterize the effect on Viking 1975 telecommunication link performance of Geodetic Earth-Orbiting Satellite (GEOS) downlink signals. The prime use of the data was to develop a capability to predict GEOS interference effects for evaluation of Viking 1975 mission impacts and possible temporary GEOS shutdown. Also, the data would serve as a basis for assessment of the GEOS impact on missions other than Viking as well as for more general interference applications. Performances of the reference receiver, telemetry, and planetary ranging were measured in the presence of various types of GEOS-related interference, including an unmodulated GEOS carrier and simulation of the actual spectrum by an ESA-supplied GEOS suitcase model.
    Keywords: SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
    Type: The Deep Space Network; p 60-74
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    Baseband recording and playback (1977)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Analog recordings of spacecraft telemetry signals are made by Deep Space Network Deep Space Stations to provide backup for both spacecraft and ground station anomalies. The requirements that must be met to insure successful baseband recording and playback are given. Recording and playback procedures are developed to insure that these requirements are met and performance results from tests conducted at the Compatibility Test Area (JPL) are tabulated.
    Keywords: SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
    Type: The Deep Space Network; p 136-145
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    Parkes-CDSCC telemetry array: Equipment design (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A unique combination of Deep Space Network (DSN) and non-DSN facilities in Australia provided enhanced data return from the Voyager spacecraft as it encountered the planet Uranus. Many of the key elements are duplicated from Voyager's encounters with Jupiter and Saturn. Some are unique extensions of that technology.
    Keywords: SPACE COMMUNICATIONS, SPACECRAFT COMMUNICATIONS, COMMAND AND TRACKING
    Type: The Telecommunications and Data Acquisition Report; 26 p
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 8
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    Satellite remote sensing facility for oceanograhic applications (1980)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The project organization, design process, and construction of a Remote Sensing Facility at Scripps Institution of Oceanography at LaJolla, California are described. The facility is capable of receiving, processing, and displaying oceanographic data received from satellites. Data are primarily imaging data representing the multispectral ocean emissions and reflectances, and are accumulated during 8 to 10 minute satellite passes over the California coast. The most important feature of the facility is the reception and processing of satellite data in real time, allowing investigators to direct ships to areas of interest for on-site verifications and experiments.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA-CR-163363 , JPL-PUB-80-40
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 9
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    Theory of phaselock techniques as applied to aerospace transponders (1964)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Phaselock techniques as applied to aerospace transponders
    Keywords: COMMUNICATIONS
    Type: NASA-CR-80567
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 10
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    A carrier-arraying demonstration at Goldstone for receiving Pioneer 11 signals (1991)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A carrier arraying technique was demonstrated at Goldstone. The Block III receivers of two 34-m antennas, Deep Space Station 12 and 15, were arrayed together to receive S band (2.3 GHz) signals from the Pioneer 11 spacecraft. Carrier phases in the two receivers were synchronized by the analog phase lock loops, and carrier signals were added at an intermediate frequency to enhance tracking performance. The receiver at DSS 15, which has been unable to lock up and track the Pioneer 11 signal by itself due to a wider tracking loop bandwidth and a higher system temperature, was now able to track the carrier and produce usable baseband signals. The receiver at DSS 12 achieved a reduction of the rms phase error, increasing the telemetry symbol SNR by an average of 0.35 dB. The baseband signals from both antennas were then synchronized and combined using the existing Baseband Assembly, thereby achieving a total symbol SNR increase of 2.5 + or - 0.7 dB relative to DSS 12 alone. A more comprehensive model is presented to permit evaluation of both thermal and phase noise effects. The analysis agrees well with observed data.
    Keywords: COMMUNICATIONS AND RADAR
    Type: The Telecommunications and Data Acquisition Report; p 307-334
    Format: text
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