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  • 1
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    Determination of the Mott-Hubbard gap in GdTiO_{3} (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-08-08
    Description: Author(s): L. Bjaalie, A. Verma, B. Himmetoglu, A. Janotti, S. Raghavan, V. Protasenko, E. H. Steenbergen, D. Jena, S. Stemmer, and C. G. Van de Walle The band gaps of rare-earth titanates are commonly reported to be 0.2–0.7 eV. These values are based on optical reflectivity measurements, from which the onset of optical absorption is derived. Here we report experimental and theoretical results on GdTiO 3 (GTO) indicating that the gap is significant… [Phys. Rev. B 92, 085111] Published Thu Aug 06, 2015
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Secreted transcription factor controls Mycobacterium tuberculosis virulence (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-08-08
    Description: Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis-the causative agent of the human disease tuberculosis-delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown. Here we show that EspR (also known as Rv3849) is a key regulator of ESX-1 that is required for secretion and virulence in mice. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. EspR directly binds to and activates the Rv3616c-Rv3614c promoter and, unexpectedly, is itself secreted from the bacterial cell by the ESX-1 system that it regulates. Efflux of the DNA-binding regulator results in reduced Rv3616c-Rv3614c transcription, and thus reduced ESX-1 secretion. Our results reveal a direct negative feedback loop that regulates the activity of a secretion system essential for virulence. As the virulence factors secreted by the ESX-1 system are highly antigenic, fine control of secretion may be critical to successful infection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862998/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862998/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raghavan, Sridharan -- Manzanillo, Paolo -- Chan, Kaman -- Dovey, Cole -- Cox, Jeffery S -- AI51667/AI/NIAID NIH HHS/ -- AI63302/AI/NIAID NIH HHS/ -- P01 AI063302/AI/NIAID NIH HHS/ -- P01 AI063302-010001/AI/NIAID NIH HHS/ -- P01 AI063302-020001/AI/NIAID NIH HHS/ -- P01 AI063302-030001/AI/NIAID NIH HHS/ -- P01 AI063302-040001/AI/NIAID NIH HHS/ -- P01 AI063302-050001/AI/NIAID NIH HHS/ -- R01 AI051667/AI/NIAID NIH HHS/ -- R01 AI051667-06/AI/NIAID NIH HHS/ -- R01 AI051667-07/AI/NIAID NIH HHS/ -- R01 AI051667-08/AI/NIAID NIH HHS/ -- England -- Nature. 2008 Aug 7;454(7205):717-21. doi: 10.1038/nature07219.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, 600 16th Street, Campus Box 2200, San Francisco, California 94143-2200, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18685700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/chemistry/genetics/*metabolism/secretion ; Gene Expression Regulation, Bacterial ; Macrophages/microbiology ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/genetics/*pathogenicity ; Operon/genetics ; Promoter Regions, Genetic/genetics ; Transcription Factors/chemistry/*metabolism/*secretion ; Transcription, Genetic ; Transcriptional Activation ; Virulence/genetics ; Virulence Factors/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Rapid and accurate large-scale coestimation of sequence alignments and phylogenetic trees (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-06-23
    Description: Inferring an accurate evolutionary tree of life requires high-quality alignments of molecular sequence data sets from large numbers of species. However, this task is often difficult, slow, and idiosyncratic, especially when the sequences are highly diverged or include high rates of insertions and deletions (collectively known as indels). We present SATe (simultaneous alignment and tree estimation), an automated method to quickly and accurately estimate both DNA alignments and trees with the maximum likelihood criterion. In our study, it improved tree and alignment accuracy compared to the best two-phase methods currently available for data sets of up to 1000 sequences, showing that coestimation can be both rapid and accurate in phylogenetic studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Kevin -- Raghavan, Sindhu -- Nelesen, Serita -- Linder, C Randal -- Warnow, Tandy -- New York, N.Y. -- Science. 2009 Jun 19;324(5934):1561-4. doi: 10.1126/science.1171243.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Sciences, University of Texas at Austin, One University Station C0500, Austin, TX 78712, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19541996" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Automation ; Computer Simulation ; Dna ; Evolution, Molecular ; Likelihood Functions ; *Phylogeny ; *Sequence Alignment/methods ; *Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Mechanical property of thin walled selective laser melted parts and the effect of heat treatment (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-12-11
    Description: The variability in mechanical properties in selective laser melted (SLM) maraging steel parts was captured by testing miniature size tensile coupons that were extracted from different locations in the part. Tensile testing provides better mechanical response to defects such as pores and inclusions as compared to hardness testing. The effect of heat treatment on the tensile property variation with different section thickness was also studied. It was observed that tensile property of miniature samples was more sensitive to porosity defects in maraging steel samples. The elongation values in the tensile specimens exhibited more variability as the section thickness of the part was reduced. This was due to the presence of more pore defects in thin wall sections. Heat treatment did not influence the tensile properties with respect to the wall thickness except for an increase in the strength due to hardening.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 5
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    Solar neutrinos--from puzzle to paradox (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-01-06
    Description: The solar neutrino puzzle is deepening into a paradox that refutes the basic logic of the reaction chain that powers the sun by the fusion of protons into heavy elements. Experiments now reveal a serious anomaly in the relative neutrino fluxes from the different steps in the chain. Neutrinos from boron-8 at the end of the chain are seen but hardly any are seen from beryllium-7, without which the observed boron-8 cannot be made. The only apparent way to avoid a paradoxical "missing link" in the sun's energy chain is a nonzero neutrino mass, an idea that can be tested in future experiments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raghavan, R S -- New York, N.Y. -- Science. 1995 Jan 6;267(5194):45-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17840056" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-02
    Description: Beta-galactosidase-deficient siblings in two litters of English springer spaniel puppies showed a progressive neurological impairment, dwarfism, orbital hypertelorism, and dysostosis multiplex. An excess of GM1-ganglioside was found in the brain. Three abnormal oligosaccharides were present in samples of urine, brain, liver, and cartilage. Light microscopy of selected tissue specimens revealed cytoplasmic vacuoles in neurons, circulating blood cells, macrophages, and chondrocytes. Ultrastructural studies demonstrated that these membrane-bound vacuoles were of two types--one containing lamellated membranes and the other, finely granular material. These clinical and pathological findings are similar to those observed in human patients affected by the infantile form of GM1-gangliosidosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alroy, J -- Orgad, U -- Ucci, A A -- Schelling, S H -- Schunk, K L -- Warren, C D -- Raghavan, S S -- Kolodny, E H -- HD 05515/HD/NICHD NIH HHS/ -- HD04147/HD/NICHD NIH HHS/ -- NS 21765/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 2;229(4712):470-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3925555" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Diseases, Metabolic/enzymology/genetics/*veterinary ; Dog Diseases/*enzymology/genetics/pathology ; Dogs ; Female ; G(M1) Ganglioside ; Gangliosidoses/enzymology/genetics/pathology/*veterinary ; Humans ; Lactose Intolerance/genetics/metabolism/*veterinary ; Male ; Neurons/pathology ; Oligosaccharides/metabolism ; Pedigree ; Vacuoles/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Dynamic Strain Aging Behavior in Dual Phase and Multiphase High Strength Steels (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-09-22
    Description: Advanced high strength steels, especially dual and multiphase steels, exhibit interesting dynamic strain aging behavior when subjected to isothermal tests at varying strain rates. In this study, uniaxial tensile testing results are presented for two selected steels over a temperature range from 25 to 200 °C at strain rates from 5 × 10 -4 to 5 × 10 -1 s -1 . At different temperature and strain rates, some specimens exhibit substantial dynamic strain aging (DSA) effects including negative rate sensitivity and formation of pronounced Portevin Le-Châtelier (PLC) bands resulting in inhomogeneous material deformation. Implications of DSA on performance consequences are addressed in the paper.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 8
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    A compact metamaterial inspired triple band antenna for reconfigurable WLAN/WiMAX applications (2015)
    Elsevier
    Details
    Publication Date: 2015-01-01
    Print ISSN: 1434-8411
    Electronic ISSN: 1618-0399
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Elsevier
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  • 9
    Electronic Resource
    Electronic Resource
    Interaction of metal particles for magnetic recording with media formulation components (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 4481-4483 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The interaction of commercially available, iron-based magnetic particles with certain particulate media formulation components has been investigated using the technique of flow microcalorimetry. The heat of wetting of these particles by solvents has been found to be a function of the solvent dipole moment and particle coercivity and surface area. Di(2-ethyl hexyl) phosphoric acid, a model dispersant, appears to interact chemically with a particle of high coercivity. Solvent basicity influences the heat and extent of interaction of the dispersant.〈lz〉 〈lz〉 〈lz〉 〈lz〉 〈lz〉 〈lz〉 〈lz〉
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.348358
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular dynamics of magnetic particulate dispersions : 38th Annual Conference on Magnetism and Magnetic Materials (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 5571-5573 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A computational investigation using the method of molecular dynamics was undertaken to characterize the state of magnetic particle dispersions. The simulations revealed that the microstructure of spherical particulate dispersions consists of chainlike clusters resulting from magnetic dipole alignment. Acicular particles formed clusters such as dimers, chains, and rings. The effect of fluid viscosity on the dispersion quality and the response of the magnetic dispersions to an external DC magnetic field are also reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.355642
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