ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice (2014)
    Oxford University Press
    Details
    Publication Date: 2014-12-24
    Description: Approaches targeting nitric oxide (NO) signaling show promise as therapies for Duchenne and Becker muscular dystrophies. However, the mechanisms by which NO benefits dystrophin-deficient muscle remain unclear, but may involve nNOSβ, a newly discovered enzymatic source of NO in skeletal muscle. Here we investigate the impact of dystrophin deficiency on nNOSβ and use mdx mice engineered to lack nNOSμ and nNOSβ to discern how the loss of nNOS impacts dystrophic skeletal muscle pathology. In mdx muscle, nNOSβ was mislocalized and its association with the Golgi complex was reduced. nNOS depletion from mdx mice prevented compensatory skeletal muscle cell hypertrophy, decreased myofiber central nucleation and increased focal macrophage cell infiltration, indicating exacerbated dystrophic muscle damage. Reductions in muscle integrity in nNOS-null mdx mice were accompanied by decreases in specific force and increased susceptibility to eccentric contraction-induced muscle damage compared with mdx controls. Unexpectedly, muscle fatigue was unaffected by nNOS depletion, revealing a novel latent compensatory mechanism for the loss of nNOS in mdx mice. Together with previous studies, these data suggest that localization of both nNOSμ and nNOSβ is disrupted by dystrophin deficiency. They also indicate that nNOS has a more complex role as a modifier of dystrophic pathology and broader therapeutic potential than previously recognized. Importantly, these findings also suggest nNOSβ as a new drug target and provide a new conceptual framework for understanding nNOS signaling and the benefits of NO therapies in dystrophinopathies.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Environments of interacting transients: impostors and Type IIn supernovae (2014)
    Oxford University Press
    Details
    Publication Date: 2014-05-21
    Description: This paper presents one of the first environmental analyses of the locations of the class of ‘interacting transients’, namely Type IIn supernovae (SNe) and SN impostors. We discuss the association of these transients with star formation, host galaxy type, metallicity and the locations of each event within the respective host. Given the frequent assumption of very high mass progenitors for these explosions from various studies, most notably a direct progenitor detection, it is interesting to note the weak association of these subtypes with star formation as traced by Hα emission, particularly in comparison with Type Ic SNe, which trace the Hα emission and are thought to arise from high-mass progenitors. The radial distributions of these transients compared to Type Ic SNe are also very different. This provides evidence for the growing hypothesis that these ‘interacting transients’ are in fact comprised of a variety of progenitor systems. The events contained within this sample are discussed in detail, where information in the literature exists, and compared to the environmental data provided. Impostors are found to split into two main classes, in terms of environment: SN 2008S-like impostors fall on regions of zero Hα emission, whereas Carina-like impostors all fall on regions with positive Hα emission. We also find indications that the impostor class originate from lower metallicity environments than Type IIn, Ic and IIP SNe.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Erythrocyte P antigen: cellular receptor for B19 parvovirus (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-10-01
    Description: The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parvoviruses in gene therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, K E -- Anderson, S M -- Young, N S -- New York, N.Y. -- Science. 1993 Oct 1;262(5130):114-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8211117" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal ; Capsid/metabolism ; Carbohydrate Sequence ; Cytopathogenic Effect, Viral ; Erythrocyte Membrane/immunology/*microbiology ; Erythroid Precursor Cells/cytology/microbiology ; Globosides/immunology/*metabolism/pharmacology ; Hemagglutination ; Humans ; Molecular Sequence Data ; P Blood-Group System/immunology/*metabolism ; Parvovirus B19, Human/immunology/*metabolism/physiology ; Phenotype ; Receptors, Virus/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    Electronic Resource
    Electronic Resource
    Near-infrared absorption spectra of 16O3 and 18O3: Adiabatic energy of the 1A2 state? (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 3826-3832 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: New absorption spectra of the 1A2(0,v2,1)←1A1(0,0,0) bands of 16O3 and 18O3 near 1 μ are reported. The behavior of vibronic band isotope shifts for low v2 suggests that the lowest point on the 1A2 surface lies 9990±70 cm−1 above the 1A1 minimum. This result is relatively insensitive to the vibrational assignment. Accounting for zero-point and binding energies of the ground state places the 1A2 minimum very close to the O+O2(v=0) dissociation limit, not low enough to support the zero-point energy of a bound state. Implications regarding recent speculation on the role of this and other electronically excited states in ozone photochemistry are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458767
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Fast-flow studies of methylidyne radical kinetics at 290 K (1987)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 91 (1987), S. 6272-6277 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100308a039
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Rate constants for hydrogen atom + oxygen + M from 298 to 639 K for M = helium nitrogen and water (1989)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 93 (1989), S. 1018-1021 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100340a003
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Surprising rate coefficients for four isotopic variants of O+O2+M (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 5385-5392 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Mass spectrometric analysis of nonequilibrium oxygen isotopic mixtures undergoing UV photolysis has been employed to study three-body recombination rate coefficients for the O+O2, Q+O2, O+Q2, and Q+Q2 (O=16O, Q=18O) reactions, all with M=80% N2:10% O2:10% Q2 at 200 Torr and 296 K. kO+O2 is in good agreement with the currently recommended value, while kQ+Q2 is only slightly smaller. Surprisingly, kQ+O2 is close to kO+O2, while kO+Q2 is (approximate)50% larger. As a consequence of this unusual behavior, kO+OQ must be (approximate)20% larger than kQ+OQ to produce the well-known enrichments that occur in the free atmosphere and in laboratory experiments involving scrambled mixtures. Contrary to what is usually assumed in discussions of the heavy ozone anomaly, these results indicate that isotopic asymmetry does not guarantee a rate coefficient advantage. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474247
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Kinetics of the isotope exchange reaction of 18O with NO and O2 at 298 K (1985)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 1648-1656 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The rates of 18O isotope exchange reactions were measured at 298 K using a discharge-flow, modulated molecular beam mass spectrometer apparatus whose detection limit for NO and O was in the 109–1010 cm−3 range. The NO exchange is very fast, k1, x=(3.7±0.5)×10−11 cm3 s−1, and, assuming statistical breakdown of a long-lived complex, the rate constant for the formation of the NO°2 complex, k1, c f is (7.4±1.0)×10−11 cm3 s−1. The slower O2 exchange was measured three different ways, yielding three rate constants whose average is k2, x=(2.9±0.5)×10−12 cm3 s−1. The results are compared with earlier isotope exchange experiments and discussed in the context of measured and calculated high pressure recombination and vibrational relaxation rate constants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.449402
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Effects of light intensity on nitrate and nitrite uptake and excretion by Chaetoceros curvisetus (1981)
    Springer
    Marine biology 62 (1981), S. 257-261 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Michaelis-Menten uptake kinetics were observed at all light intensities. With constant illumination, the Vmax and K1 in nitrate uptake over the natural light intensity range of 0 to 2000 μE were 0.343 μg-at NO3−N(μg)-1 at protein-N h-1 and 26 μE, respectively. Nitrate uptake was inhibited at higher light intensities. The Ks for nitrate uptake did not vary as a function of light intensity remaining relatively constant at 0.62 μg-at NO3−N 1-1. With intermittent illumination, the Vmzx for light intensity in nitrate uptake over a light intensity range of 0 to 5000 μE was 0.341 μg-at NO3−N(μg)-1-at protein-N h-1. No inhibition of nitrate uptake was observed at higher than natural light intensities. Chaetoceros curvisetus will probably never experience light inhibition of nitrate uptake under natural conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397692
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Selection at the Adh locus inDrosophila melanogaster: Adult survivorship-mortality in response to ethanol (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 463-464 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Functionally significant biochemical properties of the naturally occurring electrophoretic variants at the Adh locus (ADHfast and ADHSlow) are correlated with the adult flies' ability to utilize and survive in an ethanol environment. The results are consistent with the idea that an environmentally dependent form of balancing selection is responsible, at least in part, for the maintenance of the polymorphism at this locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986135
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...