Publication Date:
2013-06-22
Description:
Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amunts, Katrin -- Lepage, Claude -- Borgeat, Louis -- Mohlberg, Hartmut -- Dickscheid, Timo -- Rousseau, Marc-Etienne -- Bludau, Sebastian -- Bazin, Pierre-Louis -- Lewis, Lindsay B -- Oros-Peusquens, Ana-Maria -- Shah, Nadim J -- Lippert, Thomas -- Zilles, Karl -- Evans, Alan C -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1472-5. doi: 10.1126/science.1235381.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience and Medicine (INM-1, INM-4), Research Centre Julich, Julich, Germany. k.amunts@fz-juelich.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23788795" target="_blank"〉PubMed〈/a〉
Keywords:
Aged
;
Brain/*anatomy & histology/*cytology
;
*Brain Mapping
;
Cerebral Cortex/anatomy & histology/cytology
;
Female
;
Humans
;
Image Processing, Computer-Assisted
;
*Imaging, Three-Dimensional
;
Magnetic Resonance Imaging
;
Microtomy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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