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  • 1
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    Rapid Holocene thinning of an East Antarctic outlet glacier driven by marine ice sheet instability (2015)
    Springer Nature
    Details
    Publication Date: 2015-11-28
    Description: Article Irreversible ice loss from East Antarctic outlet glaciers during periods of ice sheet instability is yet to be observed in the geological record. Here, Jones et al . combine surface-exposure ages and model simulations to show the centennial-scale glacier thinning of Mackay Glacier during the mid-Holocene. Nature Communications doi: 10.1038/ncomms9910 Authors: R. S. Jones, A. N. Mackintosh, K. P. Norton, N. R. Golledge, C. J. Fogwill, P. W. Kubik, M. Christl, S. L. Greenwood
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
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    Role of histone H3 lysine 27 methylation in Polycomb-group silencing (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-28
    Description: Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in long-term gene silencing. However, a connection between PcG-mediated gene silencing and histone methylation has not been established. Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex. We demonstrate that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27). Using chromatin immunoprecipitation assays, we show that H3-K27 methylation colocalizes with, and is dependent on, E(Z) binding at an Ultrabithorax (Ubx) Polycomb response element (PRE), and that this methylation correlates with Ubx repression. Methylation on H3-K27 facilitates binding of Polycomb (PC), a component of the PRC1 complex, to histone H3 amino-terminal tail. Thus, these studies establish a link between histone methylation and PcG-mediated gene silencing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cao, Ru -- Wang, Liangjun -- Wang, Hengbin -- Xia, Li -- Erdjument-Bromage, Hediye -- Tempst, Paul -- Jones, Richard S -- Zhang, Yi -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1039-43. Epub 2002 Sep 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351676" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/isolation & purification/metabolism ; Cell Cycle Proteins/metabolism ; Chromatin/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Drosophila ; Drosophila Proteins/genetics/*metabolism ; *Gene Silencing ; Genes, Homeobox ; HeLa Cells ; *Histone-Lysine N-Methyltransferase ; Histones/*metabolism ; *Homeodomain Proteins ; Humans ; Lysine/*metabolism ; Methylation ; Methyltransferases/isolation & purification/metabolism ; Nuclear Proteins/metabolism ; Nucleosomes/metabolism ; Peptide Mapping ; Polycomb Repressive Complex 1 ; Polycomb Repressive Complex 2 ; Precipitin Tests ; Protein Methyltransferases ; Proteins/isolation & purification/metabolism ; RNA Interference ; Repressor Proteins/isolation & purification/metabolism ; Response Elements ; Temperature ; *Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Erratum: Properties of constraint-based single-point approximate kinetic energy functionals [Phys. Rev. B 80, 245120 (2009)] (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-06-18
    Description: Author(s): V. V. Karasiev, R. S. Jones, S. B. Trickey, and Frank E. Harris [Phys. Rev. B 87, 239903] Published Mon Jun 17, 2013
    Keywords: Errata
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Genome conformation capture reveals that the Escherichia coli chromosome is organized by replication and transcription (2013)
    Oxford University Press
    Details
    Publication Date: 2013-06-28
    Description: To fit within the confines of the cell, bacterial chromosomes are highly condensed into a structure called the nucleoid. Despite the high degree of compaction in the nucleoid, the genome remains accessible to essential biological processes, such as replication and transcription. Here, we present the first high-resolution chromosome conformation capture-based molecular analysis of the spatial organization of the Escherichia coli nucleoid during rapid growth in rich medium and following an induced amino acid starvation that promotes the stringent response. Our analyses identify the presence of origin and terminus domains in exponentially growing cells. Moreover, we observe an increased number of interactions within the origin domain and significant clustering of SeqA-binding sequences, suggesting a role for SeqA in clustering of newly replicated chromosomes. By contrast, ‘histone-like’ protein (i.e. Fis, IHF and H-NS) -binding sites did not cluster, and their role in global nucleoid organization does not manifest through the mediation of chromosomal contacts. Finally, genes that were downregulated after induction of the stringent response were spatially clustered, indicating that transcription in E. coli occurs at transcription foci.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Combining demographic and genetic factors to assess population vulnerability in stream species (2014)
    Wiley
    Details
    Publication Date: 2014-09-01
    Description: Accelerating climate change and other cumulative stressors create an urgent need to understand the influence of environmental variation and landscape features on the connectivity and vulnerability of freshwater species. Here, we introduce a novel modeling framework for aquatic systems that integrates spatially explicit, individual-based, demographic and genetic (demogenetic) assessments with environmental variables. To show its potential utility, we simulated a hypothetical network of 19 migratory riverine populations (e.g., salmonids) using a riverscape connectivity and demogenetic model (CDFISH). We assessed how stream resistance to movement (a function of water temperature, fluvial distance, and physical barriers) might influence demogenetic connectivity, and hence, population vulnerability. We present demographic metrics (abundance, immigration, and change in abundance) and genetic metrics (diversity, differentiation, and change in differentiation), and combine them into a single vulnerability index for identifying populations at risk of extirpation. We considered four realistic scenarios that illustrate the relative sensitivity of these metrics for early detection of reduced connectivity: (1) maximum resistance due to high water temperatures throughout the network, (2) minimum resistance due to low water temperatures throughout the network, (3) increased resistance at a tributary junction caused by a partial barrier, and (4) complete isolation of a tributary, leaving resident individuals only. We then applied this demogenetic framework using empirical data for a bull trout (Salvelinus confluentus) metapopulation in the upper Flathead River system, Canada and USA, to assess how current and predicted future stream warming may influence population vulnerability. Results suggest that warmer water temperatures and associated barriers to movement (e.g., low flows, dewatering) are predicted to fragment suitable habitat for migratory salmonids, resulting in the loss of genetic diversity and reduced numbers in certain vulnerable populations. This demogenetic simulation framework, which is illustrated in a web-based interactive mapping prototype, should be useful for evaluating population vulnerability in a wide variety of dendritic and fragmented riverscapes, helping to guide conservation and management efforts for freshwater species. # doi:10.1890/13-0499.1
    Print ISSN: 1051-0761
    Electronic ISSN: 1939-5582
    Topics: Biology
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 6
    Electronic Resource
    Electronic Resource
    Regulation of Hepatic Biliary Secretion (1979)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 41 (1979), S. 67-82 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.41.030179.000435
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  • 7
    Electronic Resource
    Electronic Resource
    On the spring-dashpot representation of linear viscoelastic behaviour (1990)
    Springer
    Rheologica acta 29 (1990), S. 482-484 
    Details
    ISSN: 1435-1528
    Keywords: Linear visco-elasticity ; spring-dashpot models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract Consideration is given to a simple four constant description of linear viscoelastic behaviour. It is shown that the equivalent mechanical models can be physically unrealistic, with negative moduli. Furthermore, such models satisfy the requirements of i) a positive, monotonic decreasing relaxation function, and ii) positive dissipation. By implication, it is concluded that the spring-dashpot description of linear viscoelasticity is not completely general.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01376800
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  • 8
    Electronic Resource
    Electronic Resource
    The coextrusion of two incompressible elastico-viscous fluids through a rectangular channel (1989)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 40 (1989), S. 425-439 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary The slow coextrusion of two non-Newtonian fluids through a rectangular channel is considered. The shape of the interface and the secondary flows are investigated and their dependence on the fluid properties determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00945016
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  • 9
    Electronic Resource
    Electronic Resource
    The binding of C14 labelled bacterial polysaccharide to serum proteins (1959)
    Springer
    Cellular and molecular life sciences 15 (1959), S. 104-105 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Bindung zwischen C14-markiertem Polysaccharid ausK. pneumoniae und Plasmaproteinen von Mensch, Meerschweinchen, Ratte, Maus und Hase wurde papierelektrophoretisch untersucht. Inin vitro-Versuchen konnte gezeigt werden, dass die Bindung zwischen Albumin und C14-markiertem Polysaccharid bei der Ratte am ausgeprägtesten, beim Meerschweinchen am geringsten ist.In vivo-Versuche ergaben jedoch eine erhebliche Bindung zwischen Albumin und Polysaccharid in beiden Gattungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02166698
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of halothane on the action of alcuronium in the dog (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1209-1210 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of halothane on the action of alcuronium on neuromuscular transmission was studied in the intact dog. Electrical and mechanical evoked responses from stimulation of the ulnar nerve were recorded. The administration of 0.5% halothane prolonged the duration of action of alcuronium by about 50%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963294
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