Publication Date:
2012-05-25
Description:
A fundamental question in neuroscience is how entire neural circuits generate behaviour and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to record the activity of large populations of neurons at the cellular level, throughout the brain of larval zebrafish expressing a genetically encoded calcium sensor, while the paralysed animals interact fictively with a virtual environment and rapidly adapt their motor output to changes in visual feedback. We decompose the network dynamics involved in adaptive locomotion into four types of neuronal response properties, and provide anatomical maps of the corresponding sites. A subset of these signals occurred during behavioural adjustments and are candidates for the functional elements that drive motor learning. Lesions to the inferior olive indicate a specific functional role for olivocerebellar circuitry in adaptive locomotion. This study enables the analysis of brain-wide dynamics at single-cell resolution during behaviour.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618960/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618960/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahrens, Misha B -- Li, Jennifer M -- Orger, Michael B -- Robson, Drew N -- Schier, Alexander F -- Engert, Florian -- Portugues, Ruben -- 085474/Wellcome Trust/United Kingdom -- 5K99NS62780-2/NS/NINDS NIH HHS/ -- 5R01EY014429/EY/NEI NIH HHS/ -- DP1 NS082121/NS/NINDS NIH HHS/ -- R01 DA030304/DA/NIDA NIH HHS/ -- R01 GM085357/GM/NIGMS NIH HHS/ -- R01 HL109525/HL/NHLBI NIH HHS/ -- RC2NS069407/NS/NINDS NIH HHS/ -- Wellcome Trust/United Kingdom -- England -- Nature. 2012 May 9;485(7399):471-7. doi: 10.1038/nature11057.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22622571" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological/*physiology
;
Animals
;
Animals, Genetically Modified
;
Brain/*cytology/*physiology
;
Larva/physiology
;
Learning/physiology
;
Locomotion/physiology
;
Models, Neurological
;
Nerve Net
;
Neurons/*physiology
;
Neuropil/physiology
;
Photic Stimulation
;
Psychomotor Performance/*physiology
;
Single-Cell Analysis
;
Zebrafish/anatomy & histology/growth & development/*physiology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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