Publication Date:
1989-05-12
Description:
Polyclonal antibody F547 reacts with a bovine basic fibroblast growth factor (bFGF) and a human recombinant bFGF, but not with bovine acidic fibroblast growth factor. This antibody localized bFGF in the extracellular matrix of mouse skeletal muscle, primarily in the fiber endomysium, which includes the heparin-containing basal lamina. In mdx mouse muscle, which displays persistent regeneration, FGF levels in the extracellular matrix are higher than those in controls. Overabundance of matrix FGF in mdx muscles may be related to an increase in both satellite cell and regenerative activity in the dystrophic muscle and may help explain the benign phenotype of mdx animals compared with the genetically identical human Duchenne muscular dystrophy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiMario, J -- Buffinger, N -- Yamada, S -- Strohman, R C -- R01 AG02832/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1989 May 12;244(4905):688-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2717945" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Extracellular Matrix/*metabolism
;
Fibroblast Growth Factors/*metabolism
;
Heparin/metabolism
;
Immunoblotting
;
Mice
;
Muscles/*physiopathology
;
Muscular Dystrophy, Animal/genetics/*physiopathology
;
Phenotype
;
Regeneration
;
Tissue Distribution
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink