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  • 1
    Electronic Resource
    Electronic Resource
    Primary Cultures for Studies of Cell Regulation and Physiology in Intestinal Epithelium (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 56 (1994), S. 399-417 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.56.030194.002151
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  • 2
    Electronic Resource
    Electronic Resource
    Significance of cell shape in tissue architecture (1976)
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 545-547 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 a, Line drawing of anorthic tetrakaidecahedron.This 14-sided figure consists of six equal opposite quadrilateral faces and eight equal and opposite hexagons. Each quadrilateral face is bounded by four hexagons and each hexagonal face by three hexagons and three quadrilaterals, b, When ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/264545a0
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  • 3
    Electronic Resource
    Electronic Resource
    STEM CELLS VERSUS STEM LINES (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 397 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb43416.x
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  • 4
    Electronic Resource
    Electronic Resource
    THE RESPONSE OF EPITHELIAL CELLS OF DIFFERENT HIERARCHICAL STATUS TO CYTOTOXIC INSULT (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 397 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb43449.x
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  • 5
    Electronic Resource
    Electronic Resource
    Cell kinetic studies in the epidermis of the mouse. I. Changes in labeling index with time after tritiated thymidine administration (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 1125-1129 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The changes in the labeling index (LI) with time after a single injection of tritiated thymidine (3HTdR) at each of 4 different times of the day have been studied. Slight differences occur in the shape of these LI curves, (e.g. in the timing of the peaks) depending on the time of day when the initial injection was given. Thus, the time of day influences not only the number of cells in DNA synthesis but also determines the subsequent behavior of the labeled cells. The curves show 3 distinct peaks from which estimates of the cell cycle time can be made. The technique permits the cell cycle time to be estimated. From the data as a whole a minimum cell cycle time of 90 h for basal cells in the epidermis on the back of a mouse is obtained. The technique also provides estimates for the duration of S+G2+M which varies depending on the time of day that the label is given. The LI curves can best be understood if the basal layer is assumed to contain 2 cell populations with differing cell cycle times; one having a long cell cycle (about 180 h) but short S-phase and containing the stem cells, the other having a short cell cycle (about 90 h) and a long S-phase duration and consisting of transit cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01943142
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  • 6
    Electronic Resource
    Electronic Resource
    Melanocyte precursor cells in the hair follicle germ during the dormant stage (telogen) (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 299-301 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Ursprung der Melanozyten, die in der Haarwurzel während jedes Haarzyklus erscheinen, ist bisher unbekannt gewesen. Helle dendritische Zellen im ruhenden Haarkeim, welche an der Haarpapilla liegen, die sich während der frühen Anagen teilen und während Anagen III–IV Farbkörperchen hervorbringen, sind augenscheinlich die Vorläufer der Haarmelanozyten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02034407
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  • 7
    Electronic Resource
    Electronic Resource
    Sensitivity of follicular melanoblasts in newborn mouse skin to tritiated thymidine: Evidence for a long term retention of label (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1464-1468 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Injection of tritiated thymidine into newborn mice results in a progressive greying of hair that does not begin until after the first hair coat is grown. After a year the depigmentation is appreciable (about 60% of the hair are white). The effect cannot be simulated by external irradiation of newborn mice or by the administration of radioactive uridine or methionine. The effect can best be explained by a long-term retention of radioactivity in the DNA of melanocyte stem cells (melanoblasts) in spite of several rounds of cell division. This could be achieved by labelling the strands of DNA destined to act as templates throughout life by being selectively retained in the stem line as described in Cairns' hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955773
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  • 8
    Electronic Resource
    Electronic Resource
    Apoptosis induced by high- and low-LET radiations (1995)
    Springer
    Radiation and environmental biophysics 34 (1995), S. 59-62 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought thatp53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed inp53-null animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01210548
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  • 9
    Electronic Resource
    Electronic Resource
    Changes in the cellularity of the cortex of human hairs as an indicator of radiation exposure (1996)
    Springer
    Radiation and environmental biophysics 35 (1996), S. 121-125 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Growing hair follicles with their rapid cell proliferation would be expected to be sensitive organs to cytotoxic agents such as radiation. Various abnormalities in the hair and hair follicles have been reported in the past. Changes in the number of cells in the newly forming hair cortex have been shown in the mouse to be one of the more sensitive assays for radiation effects, and this approach could provide a basis for a biological dosimeter. Here we show for the first time using hair cortex cell counts some preliminary data indicating that the number of cell nuclei in a unit of length (140 μm) of the cortex of human hairs from the chest and scalp of patients undergoing fractionated radiotherapy falls significantly (P=0.005) by 5%–10% 3 days after the first dose in a fractionated sequence of irradiations. The first dose was delivered on a Friday, and no further exposures were delivered until after the hair sample was taken on the 3rd day (Monday). No significant effect of radiation dose could be detected over the available, limited range of doses studied (5–6.5 Gy with one exit dose sample at 2.6 Gy). Also, the width varies from hair to hair. If the width of the hair is taken into account and the cortical nuclei counts are normalised to the width of each hair, the effects seen at day 3 become slightly more significant (P=0.002), and those at day 5 also become significant (P=0.012). Samples taken on the 5th day after the first (Friday) exposure were also 2 days after the second exposure and 1 day after the third exposure. However, little expression of damage attributable to the 2nd and 3rd exposures was anticipated since their effects would take some time to be expressed in the cortical region examined, which is some distance from the proliferative region of the follicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02434035
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  • 10
    Electronic Resource
    Electronic Resource
    Changes in the cellularity of the cortex of human hairs as an indicator of radiation exposure (1996)
    Springer
    Radiation and environmental biophysics 35 (1996), S. 121-125 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract   Growing hair follicles with their rapid cell proliferation would be expected to be sensitive organs to cytotoxic agents such as radiation. Various abnormalities in the hair and hair follicles have been reported in the past. Changes in the number of cells in the newly forming hair cortex have been shown in the mouse to be one of the more sensitive assays for radiation effects, and this approach could provide a basis for a biological dosimeter. Here we show for the first time using hair cortex cell counts some preliminary data indicating that the number of cell nuclei in a unit of length (140 µm) of the cortex of human hairs from the chest and scalp of patients undergoing fractionated radiotherapy falls significantly (P = 0.005) by 5%–10% 3 days after the first dose in a fractionated sequence of irradiations. The first dose was delivered on a Friday, and no further exposures were delivered until after the hair sample was taken on the 3rd day (Monday). No significant effect of radiation dose could be detected over the available, limited range of doses studied (5 – 6.5 Gy with one exit dose sample at 2.6 Gy). Also, the width varies from hair to hair. If the width of the hair is taken into account and the cortical nuclei counts are normalised to the width of each hair, the effects seen at day 3 become slightly more significant (P = 0.002), and those at day 5 also become significant (P = 0.012). Samples taken on the 5th day after the first (Friday) exposure were also 2 days after the second exposure and 1 day after the third exposure. However, little expression of damage attributable to the 2nd and 3rd exposures was anticipated since their effects would take some time to be expressed in the cortical region examined, which is some distance from the proliferative region of the follicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004110050019
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