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  • 1
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    JMSE, Vol. 7, Pages 266: Non-Hydrostatic Modeling of Waves Generated by Landslides with Different Mobility (2019)
    MDPI
    Details
    Publication Date: 2019
    Description: Tsunamis are generated when landslides transfer momentum to water, and these waves are major hazards in the mountainous coastal areas of lakes, reservoir, and fjords. In this study, the influence of slide mobility on wave generation is investigated using new: (i) experimental observations; (ii) theoretical relationships; and (iii) non-hydrostatic numerical predictions of the water surface and flow velocity evolution. This is accomplished by comparing landslides with low and high mobility and computing the momentum flux from landslides to water based on data collected in laboratory experiments. These slides have different materials, different impact velocities, different submarine runout distances, and generate very different waves. The waves evolve differently along the length of the waves’ flume, and the experimental results are in close agreement with high-resolution phase-resolving simulations. In this short communication, we describe new research on landslide generated waves conducted at Queen’s University, Canada, and presented at Coastlab18 in Santander, Spain.
    Electronic ISSN: 2077-1312
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by MDPI
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  • 2
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    Cladribine and Fludarabine Nucleoside Change the Levels of CD Antigens on B-Lymphoproliferative Disorders (2012)
    Hindawi
    Details
    Publication Date: 2012-06-19
    Description: The purine analogs, fludarabine nucleoside (FdA), and cladribine (CdA) (1 μM, 24 hours), significantly changed the levels of some surface antigens on the human B-cell lines MEC2 and Raji. Changes in the surface proteins were identified using a Cluster of Differentiation (CD) antibody microarray that captures live cells and confirmed by flow cytometry. For Raji cells, CdA up-regulated CD10, CD54, CD80, and CD86, with repression of CD22, while FdA up-regulated CD20, CD54, CD80, CD86 and CD95. For MEC2 cells, CdA up-regulated CD11a, CD20, CD43, CD45, CD52, CD54, CD62L, CD80, CD86, and CD95, but FdA had no effect. Up-regulation of particular CD antigens induced on a B-cell lymphoproliferative disorder by a purine analog could provide targets for therapeutic antibodies with synergistic cell killing.
    Print ISSN: 2090-2166
    Electronic ISSN: 2090-2174
    Topics: Biology , Chemistry and Pharmacology
    Published by Hindawi
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  • 3
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    SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-03-21
    Description: The RE1-silencing transcription factor (REST, also known as NRSF) is a master repressor of neuronal gene expression and neuronal programmes in non-neuronal lineages. Recently, REST was identified as a human tumour suppressor in epithelial tissues, suggesting that its regulation may have important physiological and pathological consequences. However, the pathways controlling REST have yet to be elucidated. Here we show that REST is regulated by ubiquitin-mediated proteolysis, and use an RNA interference (RNAi) screen to identify a Skp1-Cul1-F-box protein complex containing the F-box protein beta-TRCP (SCF(beta-TRCP)) as an E3 ubiquitin ligase responsible for REST degradation. beta-TRCP binds and ubiquitinates REST and controls its stability through a conserved phospho-degron. During neural differentiation, REST is degraded in a beta-TRCP-dependent manner. beta-TRCP is required for proper neural differentiation only in the presence of REST, indicating that beta-TRCP facilitates this process through degradation of REST. Conversely, failure to degrade REST attenuates differentiation. Furthermore, we find that beta-TRCP overexpression, which is common in human epithelial cancers, causes oncogenic transformation of human mammary epithelial cells and that this pathogenic function requires REST degradation. Thus, REST is a key target in beta-TRCP-driven transformation and the beta-TRCP-REST axis is a new regulatory pathway controlling neurogenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688689/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688689/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westbrook, Thomas F -- Hu, Guang -- Ang, Xiaolu L -- Mulligan, Peter -- Pavlova, Natalya N -- Liang, Anthony -- Leng, Yumei -- Maehr, Rene -- Shi, Yang -- Harper, J Wade -- Elledge, Stephen J -- F31 NS054507-01/NS/NINDS NIH HHS/ -- R01 AG011085/AG/NIA NIH HHS/ -- R01 AG011085-16/AG/NIA NIH HHS/ -- R01 GM054137/GM/NIGMS NIH HHS/ -- R01 GM054137-13/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Mar 20;452(7185):370-4. doi: 10.1038/nature06780.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18354483" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; Cell Line, Tumor ; *Cell Transformation, Neoplastic ; Conserved Sequence ; Humans ; Mice ; Neurons/*cytology/*pathology ; Phosphorylation ; Protein Processing, Post-Translational ; RNA Interference ; Repressor Proteins/genetics/*metabolism ; SKP Cullin F-Box Protein Ligases/*metabolism ; Substrate Specificity ; Transcription Factors/genetics/*metabolism ; Ubiquitin/metabolism ; beta-Transducin Repeat-Containing Proteins/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    An Enhanced Framework to Quantify the Shape of Impulse Waves Using Asymmetry (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract The shape of a wave generated by a landslide, snow avalanche, or fluid flow greatly influences its size and speed as it propagates away from the source region, which are critical parameters needed to estimate the impacts of these waves on coastal communities. In this study, laboratory data are produced from waves generated by the impact of water into a wave flume akin to the impact of a fluidized, highly mobile, and neutrally buoyant slide into a reservoir. Water surface observations are made using wave probes that remain at fixed positions, while the water depths and source volumes of slide material are varied. The wave shape is quantified by calculating the asymmetry about the vertical axis at each wave probe. The experimental results indicate that waves with positive or near‐zero asymmetry in the near field have a small influence on the maximum wave amplitude along the flume. However, waves with negative asymmetry in the near field change rapidly in shape and amplitude due to breaking until a stable state with symmetrical shape and wave breaking limit of 0.6 is reached. The length scale at which the breaking waves reach this state is quantified based on the initial asymmetry. An enhanced mathematical framework is developed using horizontal‐scale coefficients to modify the solitary wave equation such that it can be used to generate asymmetrical waves. This new method might be used in combination with predictions of the maximum wave amplitude to create time series needed to account for the shape of the tsunamis.
    Print ISSN: 2169-9275
    Electronic ISSN: 2169-9291
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    Alongshore momentum transfer to the nearshore zone from energetic ocean waves generated by passing hurricanes (2016)
    Wiley
    Details
    Publication Date: 2016-05-19
    Description: Wave and current measurements from a cross-shore array of nearshore sensors in Duck, NC, are used to elucidate the balance of alongshore momentum under energetic wave conditions with wide surf zones, generated by passing hurricanes that are close to and far from to the coast. The observations indicate that a distant storm (Hurricane Bill, 2009) with large waves has low variability in directional wave characteristics resulting in alongshore currents that are driven mainly by the changes in wave energy. A storm close to the coast (Hurricane Earl, 2010), with strong local wind stress and combined sea and swell components in wave energy spectra, has high variability in wave direction and wave period that influence wave breaking and nearshore circulation as the storm passes. During both large wave events the horizontal current shear is strong and radiation stress gradients, bottom stress, wind stress, horizontal mixing and cross-shore advection contribute to alongshore momentum at different spatial locations across the nearshore region. Horizontal mixing during Hurricane Earl, estimated from rotational velocities, was particularly strong suggesting that intense eddies were generated by the high horizontal shear from opposing wind-driven and wave-driven currents. The results provide insight into the cross-shore distribution of the alongshore current and the connection between flows inside and outside the surf zone during major storms, indicating that the current shear and mixing at the interface between the surf zone and shallow inner shelf is strongly dependent on the distance from the storm center to the coast. This article is protected by copyright. All rights reserved.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    Solar cells. Electron-hole diffusion lengths 〉 175 mum in solution-grown CH3NH3PbI3 single crystals (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-02-01
    Description: Long, balanced electron and hole diffusion lengths greater than 100 nanometers in the polycrystalline organolead trihalide compound CH3NH3PbI3 are critical for highly efficient perovskite solar cells. We found that the diffusion lengths in CH3NH3PbI3 single crystals grown by a solution-growth method can exceed 175 micrometers under 1 sun (100 mW cm(-2)) illumination and exceed 3 millimeters under weak light for both electrons and holes. The internal quantum efficiencies approach 100% in 3-millimeter-thick single-crystal perovskite solar cells under weak light. These long diffusion lengths result from greater carrier mobility, longer lifetime, and much smaller trap densities in the single crystals than in polycrystalline thin films. The long carrier diffusion lengths enabled the use of CH3NH3PbI3 in radiation sensing and energy harvesting through the gammavoltaic effect, with an efficiency of 3.9% measured with an intense cesium-137 source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, Qingfeng -- Fang, Yanjun -- Shao, Yuchuan -- Mulligan, Padhraic -- Qiu, Jie -- Cao, Lei -- Huang, Jinsong -- New York, N.Y. -- Science. 2015 Feb 27;347(6225):967-70. doi: 10.1126/science.aaa5760. Epub 2015 Jan 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA. ; Nuclear Engineering Program, Department of Mechanical and Aerospace Engineering, Ohio State University, Columbus, OH 43210, USA. ; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA. jhuang2@unl.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25636799" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Tsunamis generated by long and thin granular landslides in a large flume (2016)
    Wiley
    Details
    Publication Date: 2016-12-30
    Description: In this experimental study granular material is released down slope to investigate landslide-generated waves. Starting with a known volume and initial position of the landslide source, detailed data are obtained on the velocity and thickness of the granular flow, the shape and location of the submarine landslide deposit, the amplitude and shape of the near-field wave, the far-field wave evolution, and the wave runup elevation on a smooth impermeable slope. The experiments are performed on a 6.7 m long 30° slope on which gravity accelerates the landslides into a 2.1 m wide and 33.0 m long wave flume that terminates with a 27° runup ramp. For a fixed landslide volume of 0.34 m 3 , tests are conducted in a range of still water depths from 0.05-0.50 m. Observations from high-speed cameras and measurements from wave probes indicate that the granular landslide moves as a long and thin train of material, and that only a portion of the landslide (termed the ‘effective mass') is engaged in activating the leading wave. The wave behaviour is highly dependent on the water depth relative to the size of the landslide. In deeper water the near-field wave behaves as a stable solitary-like wave, while in shallower water the wave behaves as a breaking dissipative bore. Overall, the physical model observations are in good agreement with the results of existing empirical equations when the effective mass is used to predict the maximum near-field wave amplitude, the far-field amplitude and the runup of tsunamis generated by granular landslides. This article is protected by copyright. All rights reserved.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
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    Hsp90 Inhibitor SNX-7081 Dysregulates Proteins Involved with DNA Repair and Replication and the Cell Cycle in Human Chronic Lymphocytic Leukemia (CLL) Cells (2013)
    American Chemical Society (ACS)
    Details
    Publication Date: 2013-03-23
    Description: Journal of Proteome Research DOI: 10.1021/pr301055y
    Print ISSN: 1535-3893
    Electronic ISSN: 1535-3907
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 9
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    Estuarine responses to long‐term changes in inlets, morphology and sea‐level rise (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Pamlico Sound, a large back‐barrier estuary in North Carolina, is under threat of climate change due to increased storm activity and sea‐level rise. The response of this system is investigated by considering what has already happened during changes in sea‐level over the late Holocene epoch. The hydrodynamic changes that occurred in response to geomorphic evolution are simulated using a 3D numerical model for four distinct ‘time‐slice’ scenarios. To accomplish this, the present‐day bathymetry was obtained from a high resolution digital elevation model, and paleo‐bathymetric grids were developed from sediment cores and seismic observations. Using the same hydrodynamic forcing for each geomorphic scenario, the models are compared to assess the combined response to: different inlets connecting the back‐barrier estuary to the ocean; changes in basin geomorphology due to sedimentation; and sea‐level rise. The results indicate that these factors have a considerable effect on hydrodynamics, waves, and salinity in the estuary. The time‐averaged tidal ranges were up to three times as high for the past environments in comparison with present day water level elevations, and maximum current velocities were over three times higher in regions close to paleo‐inlets. The simulations for each time‐slice suggest that the salinity distribution in Pamlico Sound is strongly influenced by the hydraulic connectivity with other estuaries, and the number and size of tidal inlets through the barrier island system. The results indicate that changes to barrier systems induce strong, non‐uniform and complex responses in back‐barrier estuaries with regime‐shifts in hydrodynamic energy and water mass properties.
    Print ISSN: 2169-9275
    Electronic ISSN: 2169-9291
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
    Electronic Resource
    Electronic Resource
    Synthesis of 5,7-dimethoxyindole (1970)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 13 (1970), S. 1248-1249 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00300a066
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    Paper (German National Licenses)
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