Publication Date:
2008-03-21
Description:
Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) beta-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor-cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakao, Nobuhiro -- Ono, Hiroko -- Yamamura, Takashi -- Anraku, Tsubasa -- Takagi, Tsuyoshi -- Higashi, Kumiko -- Yasuo, Shinobu -- Katou, Yasuhiro -- Kageyama, Saburo -- Uno, Yumiko -- Kasukawa, Takeya -- Iigo, Masayuki -- Sharp, Peter J -- Iwasawa, Atsushi -- Suzuki, Yutaka -- Sugano, Sumio -- Niimi, Teruyuki -- Mizutani, Makoto -- Namikawa, Takao -- Ebihara, Shizufumi -- Ueda, Hiroki R -- Yoshimura, Takashi -- England -- Nature. 2008 Mar 20;452(7185):317-22. doi: 10.1038/nature06738.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biomodelling, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18354476" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chickens
;
Coturnix/anatomy & histology/genetics/*physiology
;
Cyclic AMP/metabolism
;
Darkness
;
Enzyme Induction
;
Female
;
Gene Expression Regulation/radiation effects
;
Genome
;
Genomics
;
Hypothalamus/metabolism/radiation effects
;
Iodide Peroxidase/biosynthesis/genetics/metabolism
;
Light
;
Luteinizing Hormone/secretion
;
Male
;
Molecular Sequence Data
;
Oligonucleotide Array Sequence Analysis
;
*Photoperiod
;
Pituitary Gland/anatomy & histology/*metabolism/*radiation effects
;
Receptors, Thyrotropin/metabolism
;
Reproduction/*physiology/*radiation effects
;
Seasons
;
Signal Transduction/radiation effects
;
Testis/growth & development
;
Thyrotropin/administration & dosage/antagonists &
;
inhibitors/immunology/*metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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