ISSN:
1573-501X
Keywords:
amines
;
diketopiperazine
;
solid phase organic synthesis (SPOS)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A `biocompatible' safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1011355300910
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