ISSN:
1420-9071
Keywords:
Carbamazepine
;
potassium
;
hippocampus
;
epilepsy
;
electrophysiology
;
4-aminopyridine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuated by the potassium-channel blockers barium chloride (0.1 mM) and 4-aminopyridine (200 μM), which suggested that potassium fluxes might be involved in the mechanism of action of carbamazepine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01958152
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