Publication Date:
2009-11-20
Description:
Abstract 3318 Poster Board III-206 Introduction Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications for allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. However, the impact of LONIPCs on survival has not been properly evaluated and little is known about treatment efficacy for LONIPCs. Patients and methods We retrospectively studied 290 consecutive adult patients (age 16 to 67 years old, median 40 years old) with hematological disorders who underwent allo-HSCT at the University of Tokyo Hospital, Japan, between June 1995 to December 2007, and survived at least 60 days after allo-HSCT. The diagnosis of LONIPCs was made when a patient fulfilled all of the following criteria: 1) respiratory symptoms developed after 60 days of allo-HSCT, 2) no evidence of infection was detected despite intensive examinations, 3) at least one of the following abnormalities are observed: a) abnormal interstitial shadows on chest computed tomography (CT), b) pathological diagnosis of interstitial pneumonia or bronchiolitis obliterans (BO), c) pulmonary function tests (PFTs) revealed obstructive or mixed pattern and FEV1 declined to less than 80 % of the predicted value, or FEV1 declined at least 20 % from baseline. According to these criteria, 44 patients were diagnosed as having LONIPCs. Then we classified them into BO and non-BO subgroups based on PFTs and CT. We compared the clinical aspects and outcome between patients who developed and did not develop LONIPCs. Time-dependent analysis was employed to conduct survival analysis. Furthermore, we analyzed the effect of treatment on outcomes. Results Onset of LONIPCs was significantly associated with higher rates of chronic graft-versus-host disease (p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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