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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 767-769 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Carrier distribution in multiple quantum well (MQW) lasers is studied by measuring laser wavelength. The MQW is designed to contain wells with different thicknesses. The MQW laser wavelength agreed with the transition wavelength of the wells near the p-clad layer at room temperature. At low temperatures, however, the laser wavelength corresponded to the thicker wells. The results imply that hole localization takes place at room temperature but disappears at low temperatures. This shows the invalidity of the conventional capture/escape model. The importance of the mean free path of unbound carriers is pointed out. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-904X
    Keywords: atrial natriuretic peptide ; brain natriuretic peptide ; clearance receptor ; neutral endopeptidase ; phosphoramidon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract To assess clearance mechanisms of atrial and brain natriuretic peptides in the circulation, we examined the effects of a neutral endopeptidase (NEP) inhibitor and a clearance receptor ligand on plasma concentrations of the peptides in normal rats. Plasma concentrations of endogenous α-rat atrial natriuretic peptide (α-rANP) were not significantly elevated by intravenous infusion of a NEP inhibitor, phosphoramidon, but were elevated threefold by intravenous infusion of a clearance receptor ligand, des(Gln18-Gly22)-rANP(4−23)-NH2 [C-ANF(4−23)]. On the other hand, the clearance of α-rANP given intravenously at the pharmacological dose, 600 pmol/ min/kg for 2 min, was decreased to one-third by the administration of phosphoramidon, although the administration of C-ANF(4−23) did not significantly decrease the clearance. The clearance of rat brain natriuretic peptide (rBNP) given at 600 pmol/min/kg for 2 min was approximately 38% lower than that of α-rANP. The effect of phosphoramidon on the clearance of rBNP was not significant and was similar to that of C-ANF(4−23). These results suggest that clearance receptor is involved in the clearance of the physiological levels of α-rANP and that NEP plays a major role in the clearance of a pharmacological dose of α-rANP, at which clearance receptors are thought to be saturated, and also indicate a pharmacokinetic difference between α-rANP and rBNP.
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  • 3
    ISSN: 1573-904X
    Keywords: arterio-venous fistula ; atrial natriuretic peptide ; heart failure ; myocardial infarction ; neutral endopeptidase ; phosphoramidon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We developed a rat model of heart failure induced by myocardial infarction (MI) which preserves responsiveness to exogenously administered natriuretic peptide, and investigated the potentiating action of neutral endopeptidase (NEP) inhibition on the renal response to endogenous natriuretic peptide in MI rats, comparing with that in the established cardiac-failing model with arterio-venous fistula (AVF). The endogenous plasma concentration of α-rat atrial natriuretic peptide (α-rANP) in the MI rat was 6.4-fold higher than that in the normal rat, and intravenous infusion of phosphoramidon (165 nmol/min/kg), an NEP inhibitor, induced larger increases in circulating α-rANP levels and natriuresis in MI rats than in normal controls. The maximal natriuretic effect of phosphoramidon (165 nmol/ min/kg) was equal to that of exogenously administered α-rANP (100 pmol/min/kg) in MI rats, whereas plasma α-rANP concentration under NEP inhibition was much lower than that after administration of α-rANP. The endogenous α-rANP levels in AVF rats were as high as those in MI rats. However, the natriuretic effect of phosphoramidon was less in AVF rats than in MI rats, which was consistent with the decreased natriuretic activity observed with administration of exogenous to α-rANP in the AVF rat. These results indicate that the natriuretic effect of NEP inhibition is dependent on elevated endogenous α-rANP levels in cardiac-failing rats, but cannot be accounted for simply in terms of the increase in circulating α-rANP levels. Endogenous natriuretic peptide-mediated natriuresis under NEP inhibition also appears to correlate with the responsiveness to the exogenously administered peptide.
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  • 4
    ISSN: 1573-904X
    Keywords: atrial natriuretic peptide ; neutral endopeptidase ; perfused kidney ; phosphoramidon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 33 (1998), S. 1015-1021 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We present a new method for the analysis of stress–strain curves for crystalline polymers such as polypropylene and polyethylene. A nonlinear constitutive equation that includes terms that cover the plastic deformation and anharmonicity of the spring is developed. In order to quantitatively characterize the nonlinear viscoelasticity using this equation, data on the transient moduli during elongation at a constant rate of strain are required. Hence, the simultaneous measurements of linear oscillatory viscoelastic moduli during a constant rate of elongation were investigated. It was found that the present method makes possible the evaluation of the plastic deformation fraction and the Gruneisen constant for crystalline polymers. © 1998 Chapman & Hall
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  • 6
    ISSN: 1573-8744
    Keywords: atrial natriuretic peptide ; brain natriuretic peptide ; neutral endopeptidase ; NONMEM ; nonlinear mixed effect model ; pharmacodynamics ; phosphoramidon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Natriuretic peptides have not only natriuretic/diuretic but also hypotensive activities, and the decreased renal perfusion caused by the excessive hypotension is known to attenuate the diuretic actions. The present study was designed to examine the relationship between the dosing (intravenous constant infusion) rates and the diuretic actions of α-rat atrial natriuretic peptide (α-rANP) and rat brain natriuretic peptide (rBNP) in rats, and population (nonlinear mixed effect model) analysis was applied to these complicated diuretic actions. The intrinsic diuretic activities of α-rANP and rBNP could be analyzed, and the effects of blood pressure, heart rate, and also inhibition of degradation enzyme on the diuresis of natriuretic peptides were estimated simultaneously. The population analysis was useful for analyzing such pharmacodynamic data for which the individual analysis could not be applied easily.
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 62 (1996), S. 87-97 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The compatibility for binary blends of isotactic polypropylene with rubbery ethylene-α-olefin copolymers having various α-olefin contents was investigated by means of differential scanning calorimetry, X-ray analysis, transmission electron microscopy, and dynamic mechanical analysis. It was found that “α-olefin rich” in ethylene-1-butene copolymers and in ethylene-1-hexene copolymers were miscible with amorphous polypropylene chains, when the α-olefin content is above 50 mol %. On the other hand, the blends with “ethylene rich” (above 50 mol % of the ethylene content) in ethylene-1-butene copolymers and ethylene-1-hexene copolymers showed a microheterogeneous morphology. © 1996 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 35 (1997), S. 953-961 
    ISSN: 0887-6266
    Keywords: ethylene-1-hexene copolymer ; polypropylene ; polymer blend ; miscibility ; crystallization ; morphology ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Morphology and isothermal growth rates of spherulites for the binary blends consisting of an isotactic polypropylene (i-PP) and an ethylene-1-hexene rubber (EHR) were examined as a function of the crystallization temperature ranging from 388 K to 418 K. In this study, two types of EHR's were employed: “ethylene rich” EHR and “1-hexene rich” EHR. The blends of i-PP with the EHR of 51 mol % 1-hexene are miscible in the molten state, whereas the blends with the EHR of 33 mol % 1-hexene are immiscible in the molten state. It is found that the isothermal spherulite growth rate of the miscible i-PP/EHR blends decreases with increasing the EHR fraction, whereas the spherulite growth rate of the immiscible i-PP/EHR blends is independent of the blend composition and is the same as that of the i-PP. Optical microscope observation of the miscible blends crystallized isothermally shows that there are no rubber domains either in the intraspherulitic or in the interspherulitic contact regions. On the other hand, the immiscible i-PP/EHR blends show a phase-separated morphology. Furthermore, the number of tangential lamellae of the miscible i-PP/EHR blends is found to be increased by blending of the EHR, leading to the spherulite with negative birefringence. The sign of birefringence of spherulites is unaffected by the regime transition as well as by the fold surface free energy. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 953-961, 1997
    Additional Material: 7 Ill.
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  • 9
    Publication Date: 2009-11-24
    Print ISSN: 0024-9297
    Electronic ISSN: 1520-5835
    Topics: Chemistry and Pharmacology , Physics
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  • 10
    Publication Date: 1998-05-01
    Print ISSN: 0024-9297
    Electronic ISSN: 1520-5835
    Topics: Chemistry and Pharmacology , Physics
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