Publication Date:
1991-12-20
Description:
Oct-1 is a transcription factor involved in the cell cycle regulation of histone H2B gene transcription and in the transcription of other cellular housekeeping genes. Oct-1 is hyperphosphorylated as cells enter mitosis, and mitosis-specific phosphorylation is reversed as cells exit mitosis. A mitosis-specific phosphorylation site in the homeodomain of Oct-1 was phosphorylated in vitro by protein kinase A. Phosphorylation of this site correlated with inhibition of Oct-1 DNA binding activity in vivo and in vitro. The inhibition of Oct-1 DNA binding during mitosis suggests a mechanism by which the general inhibition of transcription during mitosis might occur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Segil, N -- Roberts, S B -- Heintz, N -- GM 13752/GM/NIGMS NIH HHS/ -- GM 32544/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1814-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1684878" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Cattle
;
Cell Cycle
;
Cloning, Molecular
;
DNA, Neoplasm/metabolism
;
DNA-Binding Proteins/genetics/*metabolism
;
Genes, Homeobox
;
HeLa Cells
;
Histones/genetics
;
Host Cell Factor C1
;
Humans
;
Mitosis
;
Molecular Sequence Data
;
Myocardium/enzymology
;
Octamer Transcription Factor-1
;
Oligodeoxyribonucleotides
;
Peptide Mapping
;
Phosphopeptides/isolation & purification
;
Phosphorylation
;
Protein Kinases/metabolism
;
Transcription Factors/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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