Publication Date:
1990-04-20
Description:
Cytotoxic T lymphocytes (CTLs) recognize class I major histocompatibility complex (MHC) molecules associated with antigenic peptides derived from endogenously synthesized proteins. Binding to such peptides is a requirement for class I assembly in the endoplasmic reticulum (ER). A mutant human cell line, T2, assembles and transports to its surface some, but not all, class I MHC molecules. The class I molecules expressed on the surface of T2 do not present peptides derived from cytosolic antigens, although they can present exogenously added peptides to CTL. The transported class I molecules may interact weakly with an unknown retaining factor in the ER such that they can assemble despite the relative shortage of peptides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosken, N A -- Bevan, M J -- AI-19335/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1990 Apr 20;248(4953):367-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2326647" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/*immunology
;
Antigens/immunology
;
Antigens, Viral/immunology
;
B-Lymphocytes/immunology
;
Capsid/immunology
;
Cell Line
;
Endoplasmic Reticulum/immunology
;
Gene Expression
;
H-2 Antigens/genetics/immunology
;
HLA Antigens/genetics
;
Histocompatibility Antigens Class I/*immunology
;
Histocompatibility Antigens Class II/genetics
;
Humans
;
Mice
;
Mutation
;
Ovalbumin/immunology
;
Peptides/immunology
;
T-Lymphocytes, Cytotoxic/immunology
;
Transfection
;
Tumor Cells, Cultured
;
Viral Core Proteins/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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