ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Activin-A activates BMP signaling via FOP-ACVR1 [Medical Sciences] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-12-16
    Description: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by extraskeletal bone formation through endochondral ossification. FOP patients harbor point mutations in ACVR1 (also known as ALK2), a type I receptor for bone morphogenetic protein (BMP). Two mechanisms of mutated ACVR1 (FOP-ACVR1) have been proposed: ligand-independent constitutive activity and...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Counteraction by MutT protein of transcriptional errors caused by oxidative damage (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-06
    Description: Oxidized guanine (8-oxo-7,8-dihydroguanine; 8-oxo-G) is a potent mutagen because of its ambiguous pairing with cytosine and adenine. The Escherichia coli MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-rGTP), which are otherwise incorporated in DNA and RNA opposite template A. In vivo, this cleaning of the nucleotide pools decreases both DNA replication and transcription errors. The effect of mutT mutation on transcription fidelity was shown to depend on oxidative metabolism. Such control of transcriptional fidelity by the ubiquitous MutT function has implications for evolution of RNA-based life, phenotypic expression, adaptive mutagenesis, and functional maintenance of nondividing cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taddei, F -- Hayakawa, H -- Bouton, M -- Cirinesi, A -- Matic, I -- Sekiguchi, M -- Radman, M -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):128-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Jacques Monod, Tour 43, 2 place Jussieu, 75251 Paris Cedex 05, France. taddei@ijm.jussieu.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311918" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Anaerobiosis ; Bacterial Proteins/genetics/*metabolism ; Codon ; Deoxyguanine Nucleotides/metabolism ; Escherichia coli/*genetics/metabolism ; *Escherichia coli Proteins ; Guanosine Triphosphate/*analogs & derivatives/metabolism ; Hydrolysis ; Lac Operon ; *Mutation ; Oxidation-Reduction ; Phosphoric Monoester Hydrolases/genetics/*metabolism ; Point Mutation ; Pyrophosphatases ; RNA, Bacterial/biosynthesis/genetics ; RNA, Messenger/*biosynthesis/genetics ; Templates, Genetic ; *Transcription, Genetic ; Transduction, Genetic ; beta-Galactosidase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Copper/carbon nanotube composites: research trends and outlook (2018)
    Royal Society
    Details
    Publication Date: 2018-11-29
    Description: We present research progress made in developing copper/carbon nanotube composites (Cu/CNT) to fulfil a growing demand for lighter copper substitutes with superior electrical, thermal and mechanical performances. Lighter alternatives to heavy copper electrical and data wiring are needed in automobiles and aircrafts to enhance fuel efficiencies. In electronics, better interconnects and thermal management components than copper with higher current- and heat-stabilities are required to enable device miniaturization with increased functionality. Our literature survey encouragingly indicates that Cu/CNT performances (electrical, thermal and mechanical) reported so far rival that of Cu, proving the material's viability as a Cu alternative. We identify two grand challenges to be solved for Cu/CNT to replace copper in real-life applications. The first grand challenge is to fabricate Cu/CNT with overall performances exceeding that of copper. To address this challenge, we propose research directions to fabricate Cu/CNT closer to ideal composites theoretically predicted to surpass Cu performances (i.e. those containing uniformly distributed Cu and individually aligned CNTs with beneficial CNT–Cu interactions ). The second grand challenge is to industrialize and transfer Cu/CNT from lab bench to real-life use. Toward this, we identify and propose strategies to address market-dependent issues for niche/mainstream applications. The current best Cu/CNT performances already qualify for application in niche electronic device markets as high-end interconnects. However, mainstream Cu/CNT application as copper replacements in conventional electronics and in electrical/data wires are long-term goals, needing inexpensive mass-production by methods aligned with existing industrial practices. Mainstream electronics require cheap CNT template-making and electrodeposition procedures, while data/electrical cables require manufacture protocols based on co-electrodeposition or melt-processing. We note (with examples) that initiatives devoted to Cu/CNT manufacturing for both types of mainstream applications are underway. With sustained research on Cu/CNT and accelerating its real-life application, we expect the successful evolution of highly functional, efficient, and sustainable next-generation electrical and electronics systems.
    Keywords: materials science, nanotechnology
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-03-13
    Description: In vitro and in vivo model systems for the study of human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS) were used to evaluate compounds for their potential as therapeutic agents. A sulfated polysaccharide-peptidoglycan compound (SP-PG) produced by bacteria controlled the in vitro growth of acquired immunodeficiency syndrome (AIDS)-associated, KS-derived spindle-shaped cells (AIDS-KS cells) at noncytotoxic concentrations. Angiogenesis induced by AIDS-KS cells in the chicken chorioallantoic membrane assay was blocked by SP-PG, which also inhibited the vascular hyperpermeability response and the angiogenesis associated with the induction of KS-like lesions that develop after subcutaneous inoculation of AIDS-KS cells into nude mice. Suramin, pentosan polysulfate, and interferon alpha, which are currently in use for therapy of KS, were either less effective than SP-PG or much more cytotoxic, or both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakamura, S -- Sakurada, S -- Salahuddin, S Z -- Osada, Y -- Tanaka, N G -- Sakamoto, N -- Sekiguchi, M -- Gallo, R C -- New York, N.Y. -- Science. 1992 Mar 13;255(5050):1437-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Southern California, Los Angeles 90033.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1371891" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/complications ; Animals ; Arthrobacter ; Arylsulfatases ; Capillary Permeability/drug effects ; Cell Division/drug effects ; Cells, Cultured ; Endothelium, Vascular/cytology/drug effects ; Fibroblasts/drug effects ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Transplantation ; Neovascularization, Pathologic/*prevention & control ; *Peptidoglycan ; Polysaccharides/*pharmacology ; Sarcoma, Kaposi/etiology/*pathology ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Introducing Multi-Sensor Satellite Radiance-based Evaluation for Regional Earth System Modeling (2014)
    Wiley
    Details
    Publication Date: 2014-06-22
    Description: Earth System modeling has become more complex, and its evaluation using satellite data has also become more difficult due to model and data diversity. Therefore, the fundamental methodology of using satellite direct measurements with instrumental simulators should be addressed especially for modeling community members lacking a solid background of radiative transfer and scattering theory. This manuscript introduces principles of multi-satellite, multi-sensor radiance-based evaluation methods for a fully coupled regional Earth System model: NASA-Unified Weather Research and Forecasting (NU-WRF) model. We use a NU-WRF case study simulation over West Africa as an example of evaluating aerosol-cloud-precipitation-land processes with various satellite observations. NU-WRF simulated geophysical parameters are converted to the satellite-observable raw radiance and backscatter under nearly consistent physics assumptions via the multi-sensor satellite simulator, the Goddard Satellite Data Simulator Unit (G-SDSU). We present varied examples of simple yet robust methods that characterize forecast errors and model physics biases through the spatial and statistical interpretation of various satellite raw signals: infrared (IR) brightness temperature (Tb) for surface skin temperature and cloud-top temperature, microwave Tb for precipitation ice and surface flooding, and radar and lidar backscatter for aerosol-cloud profiling simultaneously. Because raw satellite signals integrate many sources of geophysical information, we demonstrate user-defined thresholds and a simple statistical process to facilitate evaluations, including the infrared-microwave-based cloud types and lidar/radar-based profile classifications.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Ice particle morphology and microphysical properties of cirrus clouds inferred from combined CALIOP–IIR measurements (2017)
    Wiley
    Details
    Publication Date: 2017-04-11
    Description: Ice particle morphology and microphysical properties of cirrus clouds are essential for assessing radiative forcing associated with these clouds. We develop an optimal estimation-based algorithm to infer cirrus cloud optical thickness (COT), cloud effective radius (CER), plate fraction including quasi-horizontally oriented plates (HOPs) and the degree of surface roughness from the Cloud Aerosol Lidar with Orthogonal Polarization (CALIOP) and the Infrared Imaging Radiometer (IIR) on the CALIPSO platform. A simple but realistic ice particle model is used, and the relevant bulk optical properties are computed using state-of-the-art light-scattering computational capabilities. Rigorous estimation of uncertainties related to surface properties, atmospheric gases and cloud heterogeneity is performed. The results based on the present method show that COTs are quite consistent with other satellite products, and CERs essentially agree with the other counterparts. A one-month global analysis for April 2007, in which CALIPSO off-nadir angle is 0.3 ∘ , shows that the HOP has significant temperature-dependence and is critical to the lidar ratio when cloud temperature is warmer than −40 ∘ C. The lidar ratio is calculated from the bulk optical properties based on the inferred parameters, showing robust temperature dependence. The median lidar ratio of cirrus clouds is 27–31 sr over the globe.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    Electronic Resource
    Electronic Resource
    Status report on electron cyclotron resonance ion sources at the Heavy Ion Medical Accelerator in Chiba : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 1061-1063 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The Heavy Ion Medical Accelerator in Chiba at the National Institute of Radiological Sciences (NIRS) is not only dedicated to cancer therapy, it is also utilized with various ion species for basic experiments of biomedical science, physics, chemistry, etc. Two electron cyclotron resonance (ECR) ion sources are installed for production of gaseous ions. One of them, the NIRS-ECR, is a 10 GHz ECR ion source, and is mainly operated to produce C4+ ions for daily clinical treatment. This source realizes good reproducibility and reliability and it is easily operated. The other source, the NIRS-HEC, is an 18 GHz ECR ion source that is expected to produce heavier ion species. The output ion currents of the NIRS-ECR and the NIRS-HEC are 430e μA for C4+ and 1.1e mA for Ar8+, respectively. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150386
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Development of a 2.45 GHz electron cyclotron resonance ion source for ion-implanter application : Proceedings of the 7th international conference on ion sources (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 837-839 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A compact electron cyclotron resonance (ECR) ion source has been designed at 2.45 GHz microwave frequency for ion implanter and is being tested. The design is based on a straightforward application of the method adopted for conventional ECR ion sources for multiply charged ions: a closed ECR surface completely contained in the plasma chamber. Initial tests have shown a promising indication: a total current of about 7 mA of Ar ions has been extracted at 25 kV extraction voltage. Design features and preliminary performance are reported. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148542
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Summary of 12th international ECRIS workshop [1995] (invited)a) (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1606-1613 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The 12th international workshop on electron cyclotron resonance ion sources (ECRIS), held on 25–27 April 1995, is summarized from the following points of view: (1) steady improvement of performance, (2) better understanding of the physical processes upon which ECR ion sources are based, (3) active pursuit for better performance by using higher magnetic field and devising new technologies, and (4) expanding application of ECRIS for highly charged ions. The upper limit of performance has not been foreseen and further improvement can be expected. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146914
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    First operation of HiECR-3 ion source for 14–18 GHz : Proceedings of the 6th international conference on ion sources (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1186-1188 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The new HiECR-3 ion source has been designed to have a mirror field and a hexapole field strong enough for both 14 and 18 GHz operation. We designed, manufactured, and operated the HiECR-3, for studying characteristics of volume and surface dependence on the electron cyclotron resonance (ECR) plasma zone. From these measurements of the ECR plasma, we examined many problems. They are the ECR plasma zone, the extraction efficiency from the plasma zone, electron injection from another ECR plasma zone, and volume and surface of the ECR plasma zone. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146727
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...