Publication Date:
1991-11-08
Description:
The mechanism of T cell depletion during infection with the human immunodeficiency virus (HIV) is unclear. Examination of the repertoire of T cell receptor V (variable) regions in persons infected with HIV revealed the absence of a common set of V beta regions, whereas V alpha usage was normal. The lack of these V beta segments did not appear to correlate with opportunistic infections. The selective elimination of T cells that express a defined set of V beta sequences may indicate the presence of an HIV-encoded superantigen, similar to those encoded by the long terminal repeat of the mouse mammary tumor virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Imberti, L -- Sottini, A -- Bettinardi, A -- Puoti, M -- Primi, D -- New York, N.Y. -- Science. 1991 Nov 8;254(5033):860-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Consorzio per le Biotecnologie-Consiglio Nazionale delle Ricerche-Institute of Chemistry, School of Medicine, University of Brescia, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948066" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/genetics/*immunology
;
Base Sequence
;
Blotting, Southern
;
DNA/genetics/isolation & purification
;
HIV/immunology
;
HIV Infections/genetics/*immunology
;
Humans
;
*Lymphocyte Depletion
;
Molecular Sequence Data
;
Oligodeoxyribonucleotides
;
Receptors, Antigen, T-Cell/*genetics
;
Reference Values
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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