Publication Date:
1995-07-14
Description:
The participation of the medial temporal cortex and other cerebral structures in the memory impairment that accompanies aging was examined by means of positron emission tomography. Cerebral blood flow (rCBF) was measured during encoding and recognition of faces. Young people showed increased rCBF in the right hippocampus and the left prefrontal and temporal cortices during encoding and in the right prefrontal and parietal cortex during recognition. Old people showed no significant activation in areas activated during encoding in young people but did show right prefrontal activation during recognition. Age-related impairments of memory may be due to a failure to encode the stimuli adequately, which is reflected in the lack of cortical and hippocampal activation during encoding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grady, C L -- McIntosh, A R -- Horwitz, B -- Maisog, J M -- Ungerleider, L G -- Mentis, M J -- Pietrini, P -- Schapiro, M B -- Haxby, J V -- New York, N.Y. -- Science. 1995 Jul 14;269(5221):218-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brain Aging and Dementia Section, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7618082" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Aged
;
Aging/*physiology
;
Cerebral Cortex/blood supply/*physiology/radionuclide imaging
;
Female
;
Hippocampus/blood supply/*physiology/radionuclide imaging
;
Humans
;
Male
;
Memory/*physiology
;
Nerve Net/physiology
;
Occipital Lobe/blood supply/physiology/radionuclide imaging
;
Parietal Lobe/blood supply/physiology/radionuclide imaging
;
Prefrontal Cortex/blood supply/physiology/radionuclide imaging
;
Regional Blood Flow
;
Tomography, Emission-Computed
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
