Publication Date:
1997-09-05
Description:
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Irie, M -- Hata, Y -- Takeuchi, M -- Ichtchenko, K -- Toyoda, A -- Hirao, K -- Takai, Y -- Rosahl, T W -- Sudhof, T C -- R01-MH52804/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1511-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe, 651-22, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9278515" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
COS Cells
;
*Calcium-Calmodulin-Dependent Protein Kinases
;
Cell Adhesion Molecules, Neuronal
;
Cell Line
;
Cell Membrane/metabolism
;
Cytoplasm/metabolism
;
Guanylate Kinase
;
Intercellular Junctions/metabolism
;
Intracellular Signaling Peptides and Proteins
;
Membrane Proteins/chemistry/*metabolism
;
Mice
;
Molecular Sequence Data
;
Nerve Tissue Proteins/chemistry/*metabolism
;
Neurons/*metabolism
;
Nucleoside-Phosphate Kinase/metabolism
;
Potassium Channels/metabolism
;
Prosencephalon/*metabolism
;
Receptors, N-Methyl-D-Aspartate/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Tumor Suppressor Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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