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  • 1
    Publication Date: 2011-02-26
    Description: Author(s): M. Walker, M. G. Brown, M. Draxler, M. G. Dowsett, C. F. McConville, T. C. Q. Noakes, and P. Bailey The atomic structure of the Cu(100)-p(2 × 2)-Sn surface has been studied using medium energy ion scattering (MEIS), co-axial impact collision ion scattering spectroscopy (CAICISS), low energy electron diffraction (LEED), and Auger electron spectroscopy (AES). The complex p(2 × 2)-based LEED patter... [Phys. Rev. B 83, 085424] Published Fri Feb 25, 2011
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2014-04-15
    Description: We present a large-scale clustering analysis of radio galaxies in the Very Large Array Faint Images of the Radio Sky at Twenty-cm survey over the Galaxy and Mass Assembly (GAMA) survey area, limited to S 1.4 GHz 〉 1 mJy with spectroscopic and photometric redshift limits up to r 〈 19.8 and 〈22 mag, respectively. For the GAMA spectroscopic matches, we present the redshift space and projected correlation functions, the latter of which yielding a correlation length r 0 ~ 8.2 h –1 Mpc and linear bias of ~1.9 at z ~ 0.34. Furthermore, we use the angular two-point correlation function w () to determine spatial clustering properties at higher redshifts. We find r 0 to increase from ~6 to ~14 h –1 Mpc between z  = 0.3 and 1.55, with the corresponding bias increasing from ~2 to ~10 over the same range. Our results are consistent with the bias prescription implemented in the SKA Design Study simulations at low redshift, but exceed these predictions at z  〉 1. This is indicative of an increasing (rather than fixed) halo mass and/or active galactic nuclei fraction at higher redshifts or a larger typical halo mass for the more abundant Fanaroff and Riley Class I sources.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 3
    Publication Date: 2015-12-28
    Description: Testing for conserved and novel mechanisms underlying phenotypic evolution requires a diversity of genomes available for comparison spanning multiple independent lineages. For example, complex social behavior in insects has been investigated primarily with eusocial lineages, nearly all of which are Hymenoptera. If conserved genomic influences on sociality do exist, we need data from a wider range of taxa that also vary in their levels of sociality. Here, we present the assembled and annotated genome of the subsocial beetle Nicrophorus vespilloides , a species long used to investigate evolutionary questions of complex social behavior. We used this genome to address two questions. First, do aspects of life history, such as using a carcass to breed, predict overlap in gene models more strongly than phylogeny? We found that the overlap in gene models was similar between N. vespilloides and all other insect groups regardless of life history. Second, like other insects with highly developed social behavior but unlike other beetles, does N. vespilloides have DNA methylation? We found strong evidence for an active DNA methylation system. The distribution of methylation was similar to other insects with exons having the most methylated CpGs. Methylation status appears highly conserved; 85% of the methylated genes in N. vespilloides are also methylated in the hymentopteran Nasonia vitripennis . The addition of this genome adds a coleopteran resource to answer questions about the evolution and mechanistic basis of sociality and to address questions about the potential role of methylation in social behavior.
    Electronic ISSN: 1759-6653
    Topics: Biology
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  • 4
    Publication Date: 2013-02-02
    Description: A single cytosine–guanine dinucleotide (CpG) site within coagulation factor II (thrombin) receptor-like 3 ( F2RL3 ) was recently found to be hypomethylated in peripheral blood genomic DNA from smokers compared with former and non-smokers. We performed two epigenome-wide association studies (EWAS) nested in a prospective healthy cohort using the Illumina 450K Methylation Beadchip. The two populations consisted of matched pairs of healthy individuals ( n = 374), of which half went on to develop breast or colon cancer. The association was analysed between methylation and smoking status, as well as cancer risk. In addition to the same locus in F2RL3 , we report several loci that are hypomethylated in smokers compared with former and non-smokers, including an intragenic region of the aryl hydrocarbon receptor repressor gene ( AHRR ; cg05575921, P = 2.31 x 10 –15 ; effect size = 14–17%), an intergenic CpG island on 2q37.1 (cg21566642, P = 3.73 x 10 –13 ; effect size = 12%) and a further intergenic region at 6p21.33 (cg06126421, P = 4.96 x 10 –11 , effect size = 7–8%). Bisulphite pyrosequencing validated six loci in a further independent population of healthy individuals ( n = 180). Methylation levels in AHRR were also significantly decreased ( P 〈 0.001) and expression increased ( P = 0.0047) in the lung tissue of current smokers compared with non-smokers. This was further validated in a mouse model of smoke exposure. We observed an association with breast cancer risk for the 2q37.1 locus ( P = 0.003, adjusted for the smoking status), but not for the other loci associated with smoking. These data show that smoking has a direct effect on the epigenome in lung tissue, which is also detectable in peripheral blood DNA and may contribute to cancer risk.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2001-05-08
    Description: Vibrational studies that selectively probe molecular structure at CCl4/H2O and hydrocarbon/H2O interfaces show that the hydrogen bonding between adjacent water molecules at these interfaces is weak, in contrast to generally accepted models of water next to fluid hydrophobic surfaces that suggest strong hydrogen bonding. However, interactions between these water molecules and the organic phase result in substantial orientation of these weakly hydrogen-bonded water molecules in the interfacial region. The results have important implications for understanding water adjacent to hydrophobic surfaces and the penetration of water into hydrophobic phases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scatena, L F -- Brown, M G -- Richmond, G L -- New York, N.Y. -- Science. 2001 May 4;292(5518):908-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Oregon, Eugene OR 97403, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11340199" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2001-05-08
    Description: Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, M G -- Dokun, A O -- Heusel, J W -- Smith, H R -- Beckman, D L -- Blattenberger, E A -- Dubbelde, C E -- Stone, L R -- Scalzo, A A -- Yokoyama, W M -- New York, N.Y. -- Science. 2001 May 4;292(5518):934-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11340207" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/immunology ; *Antigens, Ly ; Crosses, Genetic ; Cytotoxicity, Immunologic ; Female ; Haplotypes ; Herpesviridae Infections/*immunology ; Histocompatibility Antigens Class I/immunology ; Humans ; *Immunity, Innate ; Killer Cells, Natural/*immunology ; Lectins, C-Type ; Ligands ; *Lymphocyte Activation ; Male ; Membrane Glycoproteins/genetics/*immunology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Muromegalovirus/*immunology ; Phenotype ; Receptors, Immunologic/*immunology ; Receptors, NK Cell Lectin-Like ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 1999-05-13
    Description: A polarizable water pair potential was determined by fitting a potential form to microwave, terahertz, and mid-infrared (D2O)2 spectra through a rigorous calculation of the water dimer eigenstates. It accurately reproduces most ground state vibration-rotation-tunneling spectra and yields excellent second viral coefficients. The calculated dimer structure and dipole moment are very close to those determined from microwave spectroscopy and high-level ab initio calculations. The dimer binding energy and acceptor switching and donor-acceptor interchange tunneling barriers are in excellent agreement with recent ab initio theory, as are cyclic water trimer and tetramer structures and binding energies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fellers, R S -- Leforestier, C -- Braly, L B -- Brown, M G -- Saykally, R J -- New York, N.Y. -- Science. 1999 May 7;284(5416):945-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley 94720-1460, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10320371" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Deuterium Oxide/*chemistry ; Dimerization ; Hydrogen Bonding ; Microwaves ; *Models, Molecular ; Regression Analysis ; Spectrum Analysis/methods ; Water/*chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1997-02-07
    Description: The average dipole moment of a water molecule in the condensed phase is enhanced by around 40 percent relative to that of an isolated monomer. This enhancement results from the large polarization caused by the electric field induced by surrounding monomers. A quantitative molecular description of this polarization is essential for modeling aqueous solvation phenomena. This combined theoretical and experimental study of dipole moments in small water clusters provides such a description and also gives insights into the structure of liquid water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregory -- Clary -- Liu -- Brown -- Saykally -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):814-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. K. Gregory, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. D. C. Clary, Department of Chemistry, University College London, London WC1H OAJ, UK. K. Liu, M. G. Brown, R. J. Saykally, Department of Chemistry, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9012344" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 1996-01-05
    Description: Measurement of the far-infrared vibration-rotation tunneling spectrum of the perdeuterated water tetramer is described. Precisely determined rotational constants and relative intensity measurements indicate a cyclic quasi-planar minimum energy structure, which is in agreement with recent ab initio calculations. The O-O separation deduced from the data indicates a rapid exponential convergence to the ordered bulk value with increasing cluster size. Observed quantum tunneling splittings are interpreted in terms of hydrogen bond rearrangements connecting two degenerate structures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cruzan, J D -- Braly, L B -- Liu, K -- Brown, M G -- Loeser, J G -- Saykally, R J -- New York, N.Y. -- Science. 1996 Jan 5;271(5245):59-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California at Berkeley 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11536731" target="_blank"〉PubMed〈/a〉
    Keywords: Deuterium Oxide/*chemistry ; Hydrogen/*chemistry ; Models, Chemical ; Oxygen/chemistry ; Spectrophotometry, Infrared ; Spectroscopy, Near-Infrared ; Water/*chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 6634-6644 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The far-infrared vibration–rotation–tunneling spectrum of (D2O)4 has been measured in the spectral region near 2.04 THz. Observation of additional transition doublets with a constant 5.6 MHz spacing in a parallel (c-type) spectrum extends the first detailed study of this cluster [Science 271, 59 (1996)]. Three possibilities are explored for the origin of this small splitting: tunneling between degenerate equilibrium structures via facile torsional motions analogous to those observed in the water trimer, tunneling between nondegenerate structural frameworks, and tunneling made feasible only through excitation of a specific vibrational coordinate. The degenerate tunneling scheme best accounts for the spectral features, although the precise dynamics responsible for the observed spectral features cannot be uniquely established from the present data. A further doubling of spectral features, observed only in the K=2 manifold of transitions for J≥3, is symmetric about the unperturbed symmetric top energy levels and shows an approximate J2 dependence of the spacing. The origin of these additional splittings, which are shown to be present in both upper and lower vibrational states of the spectrum, is likely to be due to an interaction between overall rotational angular momentum and the type of internal motion ("pseudorotation'') that gives rise to a manifold of low energy states in water trimer. The measured interoxygen separations in (D2O)n (n=2,3,4,5) are analyzed in order to quantify the contribution of many-body forces in bulk water. An exponential contraction of this property toward the value found in ordered ice is observed. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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