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  • 1
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    Detection of tissue properties using a piezoelectric vibration-based syringe (2012)
    Institute of Physics (IOP)
    Details
    Publication Date: 2012-12-11
    Description: For safety improvement purposes, detection of tissue properties at the tip of the needle in real-time is helpful in controlling the movement of the needle in the operation of invasive surgical tools. According to the energy-based force model, the mechanical impedance of tissue can be represented approximately by a spring-damping model. In this study, a vibration-based syringe which adopts piezoelectric elements to vibrate the needle is proposed to identify tissue properties. In principle, by measuring the input electrical impedance of the vibration-based syringe, the mechanical impedance of tissue can be detected indirectly while the syringe exerts a vibration on the tissue. The model of the piezoelectric driven syringe and the procedure for evaluating the electromechanical interaction are given, and the mechanical impedance of tissue is evaluated by simulation. The proposed detection method has potential for applications of identifying tissue properties in epidural punctures an...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 2
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    A piezoelectric vibration-based syringe for reducing insertion force (2012)
    Institute of Physics (IOP)
    Details
    Publication Date: 2012-12-11
    Description: Puncturing of the human skin with a needle is perhaps the most common invasive medical procedure. Clinical studies have revealed that tissue deformation and needle deflection are the primary problem for needle misplacement in percutaneous procedures. To avoid this, various techniques for reducing insertion forces during needle insertion have been considered. This paper presents a piezoelectric vibration-based syringe to reduce insertion force. AC power was applied to the piezoelectric elements to vibrate the needle with high frequency and thereby reduce the friction and cutting forces between the needle and tissue. Vibration mode shapes of the needle were observed by finite element analysis and verified by experimental results. Effects of reducing insertion force via the vibrating needle were also confirmed by inserting the needle into the porcine tissues. The proposed syringe, which minimizes the insertion force and overcomes limitations of needle materials, can be widely utili...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 3
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    Coagulation factor VII and malignant progression of hepatocellular carcinoma (2016)
    Springer Nature
    Details
    Publication Date: 2016-02-26
    Description: Coagulation factor VII and malignant progression of hepatocellular carcinoma Cell Death and Disease 7, e2110 (February 2016). doi:10.1038/cddis.2015.395 Authors: K-D Chen, K-T Huang, M-C Tsai, C-H Wu, I-Y Kuo, L-Y Chen, T-H Hu, C-L Chen & C-C Lin
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 4
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    Structural Dynamics of GaN Microcrystals in Evolutionary Selection Selective Area Growth probed by X-ray Microdiffraction (2014)
    Springer Nature
    Details
    Publication Date: 2014-04-12
    Description: A method to grow high quality, single crystalline semiconductor material irrespective of the substrate would allow a cost-effective improvement to functionality and performance of optoelectronic devices. Recently, a novel type of substrate-insensitive growth process called Evolutionary Selection Selective Area Growth (ES-SAG) has been proposed. Here we report the use of X-ray microdiffraction to study the structural properties of GaN microcrystals grown by ES-SAG. Utilizing high resolution in both direct and reciprocal spaces, we have unraveled structural dynamics of GaN microcrystals in growth structures of different dimensions. It has been found that the geometric proportions of the growth constrictions play an important role: 2.6 μm and 4.5 μm wide growth tunnels favor the evolutionary selection mechanism, contrary to the case of 8.6 μm growth tunnels. It was also found that GaN microcrystal ensembles are dominated by slight tensile strain irrespective of growth tunnel shape. Scientific Reports 4 doi: 10.1038/srep04651
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 5
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    Long noncoding RNA as modular scaffold of histone modification complexes (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-10
    Description: Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct histone modification complexes. A 5' domain of HOTAIR binds polycomb repressive complex 2 (PRC2), whereas a 3' domain of HOTAIR binds the LSD1/CoREST/REST complex. The ability to tether two distinct complexes enables RNA-mediated assembly of PRC2 and LSD1 and coordinates targeting of PRC2 and LSD1 to chromatin for coupled histone H3 lysine 27 methylation and lysine 4 demethylation. Our results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967777/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967777/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsai, Miao-Chih -- Manor, Ohad -- Wan, Yue -- Mosammaparast, Nima -- Wang, Jordon K -- Lan, Fei -- Shi, Yang -- Segal, Eran -- Chang, Howard Y -- R01 CA118750/CA/NCI NIH HHS/ -- R01 CA119176/CA/NCI NIH HHS/ -- R01 CA119176-05/CA/NCI NIH HHS/ -- R01-CA118487/CA/NCI NIH HHS/ -- R01-HG004361/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Aug 6;329(5992):689-93. doi: 10.1126/science.1192002. Epub 2010 Jul 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20616235" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carrier Proteins/metabolism ; Cell Line ; Cells, Cultured ; Chromatin/*metabolism ; Chromatin Immunoprecipitation ; Co-Repressor Proteins ; DNA-Binding Proteins/*metabolism ; HeLa Cells ; Histone Demethylases/*metabolism ; Histones/*metabolism ; Humans ; Methylation ; Mutation ; Nerve Tissue Proteins/metabolism ; Nuclear Proteins/metabolism ; Nucleic Acid Conformation ; Polycomb Repressive Complex 2 ; Polycomb-Group Proteins ; Promoter Regions, Genetic ; Protein Binding ; RNA Interference ; RNA, Untranslated/chemistry/*metabolism ; Repressor Proteins/*metabolism ; Transcription Factors/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Albuquerque, E X -- Eldefrawi, A T -- Eldefrawi, M E -- Mansour, N A -- Tsai, M C -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):788-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622570" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism/*physiology ; Amantadine/*pharmacology ; Animals ; Electric Conductivity ; Electric Organ/drug effects/metabolism/physiology ; Fishes ; In Vitro Techniques ; Membrane Potentials/drug effects ; Motor Endplate/drug effects/metabolism/physiology ; Muscle Denervation ; Muscles/innervation/metabolism ; *Neuromuscular Blocking Agents ; Neuromuscular Junction/drug effects/metabolism/physiology ; Rats ; Receptors, Cholinergic/*drug effects ; Receptors, Nicotinic/*drug effects/metabolism/physiology ; Toxins, Biological/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-16
    Description: Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNAs can function as the interface between DNA and specific chromatin remodelling activities. Here we show that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression. The lincRNA termed HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in primary tumours is a powerful predictor of eventual metastasis and death. Enforced expression of HOTAIR in epithelial cancer cells induced genome-wide re-targeting of Polycomb repressive complex 2 (PRC2) to an occupancy pattern more resembling embryonic fibroblasts, leading to altered histone H3 lysine 27 methylation, gene expression, and increased cancer invasiveness and metastasis in a manner dependent on PRC2. Conversely, loss of HOTAIR can inhibit cancer invasiveness, particularly in cells that possess excessive PRC2 activity. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049919/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049919/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, Rajnish A -- Shah, Nilay -- Wang, Kevin C -- Kim, Jeewon -- Horlings, Hugo M -- Wong, David J -- Tsai, Miao-Chih -- Hung, Tiffany -- Argani, Pedram -- Rinn, John L -- Wang, Yulei -- Brzoska, Pius -- Kong, Benjamin -- Li, Rui -- West, Robert B -- van de Vijver, Marc J -- Sukumar, Saraswati -- Chang, Howard Y -- R01 CA118750/CA/NCI NIH HHS/ -- R01 CA118750-03/CA/NCI NIH HHS/ -- R01 HG004361/HG/NHGRI NIH HHS/ -- R01 HG004361-03/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Apr 15;464(7291):1071-6. doi: 10.1038/nature08975.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Program in Epithelial Biology, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393566" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/genetics/pathology ; Cell Line, Tumor ; Cell Proliferation ; Chromatin/*genetics ; Chromatin Assembly and Disassembly/*genetics ; Disease Progression ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Homeobox/genetics ; Genome, Human/genetics ; Histones/metabolism ; Humans ; Methylation ; Mice ; Mice, Nude ; Mice, SCID ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Metastasis/*genetics ; Neoplasm Transplantation ; Polycomb-Group Proteins ; Prognosis ; RNA Interference ; RNA, Untranslated/biosynthesis/*genetics ; Repressor Proteins/analysis/metabolism ; Survival Rate
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma (2014)
    Springer Nature
    Details
    Publication Date: 2014-05-23
    Description: Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma Cell Death and Disease 5, e1244 (May 2014). doi:10.1038/cddis.2014.212 Authors: K-D Chen, C-C Wang, M-C Tsai, C-H Wu, H-J Yang, L-Y Chen, T Nakano, S Goto, K-T Huang, T-H Hu, C-L Chen & C-C Lin
    Keywords: autophagyhepatocellular carcinomatissue factorfactor VIIprotease-activated receptor 2mammalian target of rapamycin
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 9
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    A Novel Measurement for Monitoring Mechanical Impedance Applied to Breakthrough Detection of Bone-Drill System (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-08-21
    Description: Based on a Chain Scattering Description and the Hilbert Huang Transform, this paper proposes a new measurement for monitoring dynamic changes of mechanical impedance without applying conventionally mechanical sensors. The proposed method is applied to the bone drilling system to detect the moment of bone breakthrough. The single frequency mechanical impedance of bone can be computed from the electrical signal of a DC motor in accordance with the proposed method. The experimental results demonstrate that the moment of bone breakthrough can accurately be detected by monitoring changes of mechanical impedance.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 10
    Electronic Resource
    Electronic Resource
    Temperature-swing separation of hydrogen-methane mixture (1985)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 24 (1985), S. 57-62 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i200028a010
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    Paper (German National Licenses)
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