Publication Date:
2014-12-06
Description:
Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate Drosophila cells perceived as unfit. We find that Toll-related receptors (TRRs) and the cytokine Spatzle (Spz) lead to NFkappaB-dependent apoptosis. Diverse "loser" cells require different TRRs and NFkappaB factors and activate distinct pro-death genes, implying that the particular response is stipulated by the competitive context. Our findings demonstrate a functional repurposing of components of TRRs and NFkappaB signaling modules in the surveillance of cell fitness during development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, S N -- Amoyel, M -- Bergantinos, C -- de la Cova, C -- Schertel, C -- Basler, K -- Johnston, L A -- P40OD018537/OD/NIH HHS/ -- R01 GM078464/GM/NIGMS NIH HHS/ -- R01-GM084947/GM/NIGMS NIH HHS/ -- R21 HD067918/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1258236. doi: 10.1126/science.1258236.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. ; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. ; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. konrad.basler@imls.uzh.ch lj180@columbia.edu. ; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. konrad.basler@imls.uzh.ch lj180@columbia.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477468" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis/genetics/*immunology
;
Cell Communication/*immunology
;
Drosophila Proteins/genetics/metabolism
;
Drosophila melanogaster/cytology/genetics/growth & development
;
Immunity, Innate/genetics/*immunology
;
Mutation
;
NF-kappa B/genetics/*metabolism
;
Neuropeptides/genetics
;
Toll-Like Receptors/genetics/*metabolism
;
Transcription Factors/metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
