Publication Date:
2010-10-12
Description:
To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications of these for colour vision. Multi-electrode technology was used to record simultaneously from complete populations of the retinal ganglion cell types (midget, parasol and small bistratified) that transmit high-resolution visual signals to the brain. Fine-grained visual stimulation was used to identify the location, type and strength of the functional input of each cone photoreceptor to each ganglion cell. The populations of ON and OFF midget and parasol cells each sampled the complete population of long- and middle-wavelength-sensitive cones. However, only OFF midget cells frequently received strong input from short-wavelength-sensitive cones. ON and OFF midget cells showed a small non-random tendency to selectively sample from either long- or middle-wavelength-sensitive cones to a degree not explained by clumping in the cone mosaic. These measurements reveal computations in a neural circuit at the elementary resolution of individual neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953734/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953734/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Field, Greg D -- Gauthier, Jeffrey L -- Sher, Alexander -- Greschner, Martin -- Machado, Timothy A -- Jepson, Lauren H -- Shlens, Jonathon -- Gunning, Deborah E -- Mathieson, Keith -- Dabrowski, Wladyslaw -- Paninski, Liam -- Litke, Alan M -- Chichilnisky, E J -- EY13150/EY/NEI NIH HHS/ -- F31 NS054519-01/NS/NINDS NIH HHS/ -- NS054519-01/NS/NINDS NIH HHS/ -- R01 EY013150/EY/NEI NIH HHS/ -- R01 EY013150-05/EY/NEI NIH HHS/ -- T32 HD007430/HD/NICHD NIH HHS/ -- England -- Nature. 2010 Oct 7;467(7316):673-7. doi: 10.1038/nature09424.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20930838" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Color
;
Color Perception/*physiology
;
Color Vision/*physiology
;
Light
;
Macaca/*physiology
;
Macaca fascicularis/physiology
;
Macaca mulatta/physiology
;
Models, Neurological
;
Neural Pathways/*physiology
;
Photic Stimulation
;
Retinal Cone Photoreceptor Cells/*cytology/*physiology
;
Retinal Ganglion Cells/cytology/physiology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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