ISSN:
1399-0047
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
The Escherichia coli OXA-1 oxacillinase, a β-lactamase which provides resistance to β-lactam antibiotics (penicillins and cephalosporins), has been crystallized. A member of the class D family of serine β-lactamases, OXA-1 is especially active against the penicillins oxacillin and cloxacillin and is now found in 10% of E. coli clinical isolates. Crystals grown from PEG 8000 at pH 7.5 diffract to 1.5 Å resolution at 100 K and have space group P1 (Z = 2), with unit-cell parameters a = 36.0, b = 51.6, c = 72.9 Å, α = 70.2, β = 84.1, γ = 81.5°.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S0907444901016274
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