ISSN:
1573-739X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A method is described that extracts fluoride selectively as trimethylfluorosilane using carbon tetrachloride and trimethylchlorosilane. Drawbacks of other methods as well as advantages of the proposed method are discussed. The method is directly applicable to plasma and faeces samples, has a short gas Chromatographic run time due to the use of a backflush technique and is suitable for automation. Its lowest quantifiable limit for plasma and faeces is 10 μg/l and 1 μg/g fluoride respectively, using 1.0 ml or 1.0 g samples. Preliminary pharmacokinetic parameters of fluoride obtained in two subjects are reported.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01953958
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