Publication Date:
2006-05-13
Description:
The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus. Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight. The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cota, Daniela -- Proulx, Karine -- Smith, Kathi A Blake -- Kozma, Sara C -- Thomas, George -- Woods, Stephen C -- Seeley, Randy J -- DK 17844/DK/NIDDK NIH HHS/ -- DK 54080/DK/NIDDK NIH HHS/ -- DK 54890/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2006 May 12;312(5775):927-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16690869" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arcuate Nucleus of Hypothalamus/cytology/enzymology/metabolism
;
*Eating
;
*Energy Intake
;
*Energy Metabolism
;
Fasting
;
Hypothalamus/enzymology/*metabolism
;
Injections, Intraventricular
;
Leptin/pharmacology
;
Leucine/*administration & dosage/pharmacology
;
Neurons/enzymology/*metabolism
;
Neuropeptide Y/genetics/metabolism
;
Phosphorylation
;
Protein Kinases/*metabolism
;
Rats
;
Rats, Long-Evans
;
Ribosomal Protein S6/metabolism
;
Ribosomal Protein S6 Kinases/metabolism
;
STAT3 Transcription Factor/metabolism
;
*Signal Transduction
;
Sirolimus/administration & dosage/pharmacology
;
TOR Serine-Threonine Kinases
;
Valine/administration & dosage/pharmacology
;
Weight Loss
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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