Publikationsdatum:
2008-03-01
Beschreibung:
Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen level-dependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉D'Ardenne, Kimberlee -- McClure, Samuel M -- Nystrom, Leigh E -- Cohen, Jonathan D -- F32 MH072141/MH/NIMH NIH HHS/ -- P50 MH062196/MH/NIMH NIH HHS/ -- T32 MH065214/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1264-7. doi: 10.1126/science.1150605.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. dardenne@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309087" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Adolescent
;
Adult
;
Basal Ganglia/physiology
;
Conditioning, Classical
;
Cues
;
Dopamine/*physiology
;
Female
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Mental Processes/*physiology
;
Oxygen/blood
;
Probability
;
Reinforcement (Psychology)
;
*Reward
;
Ventral Tegmental Area/*physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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