ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    The TLR4 antagonist Eritoran protects mice from lethal influenza infection (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-05-03
    Description: There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous studies reported that acute lung injury caused by chemical or microbial insults is secondary to the generation of host-derived, oxidized phospholipid that potently stimulates Toll-like receptor 4 (TLR4)-dependent inflammation. Subsequently, we reported that Tlr4(-/-) mice are highly refractory to influenza-induced lethality, and proposed that therapeutic antagonism of TLR4 signalling would protect against influenza-induced acute lung injury. Here we report that therapeutic administration of Eritoran (also known as E5564)-a potent, well-tolerated, synthetic TLR4 antagonist-blocks influenza-induced lethality in mice, as well as lung pathology, clinical symptoms, cytokine and oxidized phospholipid expression, and decreases viral titres. CD14 and TLR2 are also required for Eritoran-mediated protection, and CD14 directly binds Eritoran and inhibits ligand binding to MD2. Thus, Eritoran blockade of TLR signalling represents a novel therapeutic approach for inflammation associated with influenza, and possibly other infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725830/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725830/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shirey, Kari Ann -- Lai, Wendy -- Scott, Alison J -- Lipsky, Michael -- Mistry, Pragnesh -- Pletneva, Lioubov M -- Karp, Christopher L -- McAlees, Jaclyn -- Gioannini, Theresa L -- Weiss, Jerrold -- Chen, Wilbur H -- Ernst, Robert K -- Rossignol, Daniel P -- Gusovsky, Fabian -- Blanco, Jorge C G -- Vogel, Stefanie N -- AI018797/AI/NIAID NIH HHS/ -- AI057575/AI/NIAID NIH HHS/ -- AI059372/AI/NIAID NIH HHS/ -- NCRR K12-RR-023250/PHS HHS/ -- R01 AI018797/AI/NIAID NIH HHS/ -- R01 AI057575/AI/NIAID NIH HHS/ -- R01 AI059372/AI/NIAID NIH HHS/ -- T32 AI007540/AI/NIAID NIH HHS/ -- England -- Nature. 2013 May 23;497(7450):498-502. doi: 10.1038/nature12118. Epub 2013 May 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23636320" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Lung Injury/complications/drug therapy/pathology/prevention & control ; Animals ; Antigens, CD14/metabolism ; Antiviral Agents/*pharmacology/therapeutic use ; Cytokines/genetics/immunology ; Disaccharides/metabolism/*pharmacology/*therapeutic use ; Female ; Influenza A Virus, H1N1 Subtype/*drug effects/*pathogenicity ; Ligands ; Lymphocyte Antigen 96/metabolism ; Mice ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/*drug therapy/immunology/pathology/virology ; Sugar Phosphates/metabolism/*pharmacology/*therapeutic use ; Survival Analysis ; Time Factors ; Toll-Like Receptor 2/immunology/metabolism ; Toll-Like Receptor 4/*antagonists & inhibitors/immunology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity (2008)
    National Academy of Sciences
    Details
    Publication Date: 2008-12-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Enhanced allergic responsiveness after early childhood infection with respiratory viruses: Are long-lived alternatively activated macrophages the missing link? (2016)
    Oxford University Press
    Details
    Publication Date: 2016-06-04
    Description: Early childhood infection with respiratory viruses, including human rhinovirus, respiratory syncytial virus (RSV) and influenza, is associated with an increased risk of allergic asthma and severe exacerbation of ongoing disease. Despite the long recognition of this relationship, the mechanism linking viral infection and later susceptibility to allergic lung inflammation is still poorly understood. We discuss the literature and provide new evidence demonstrating that these viruses induce the alternative activation of macrophages. Alternatively activated macrophages (AAM) induced by RSV or influenza infection persisted in the lungs of mice up to 90 days after initial viral infection. Several studies suggest that AAM contribute to allergic inflammatory responses, although their mechanism of action is unclear. In this commentary, we propose that virus-induced AAM provide a link between viral infection and enhanced responses to inhaled allergens.
    Print ISSN: 0928-8244
    Topics: Biology , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Operation of A Sunpower M87 Cryocooler In A Magnetic Field (2002)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Alpha Magnetic Spectrometer-02 (AMS-02) is an experiment that will be flown as an attached payload on the International Space Station to detect dark matter and antimatter. It uses large superconducting magnets cooled with superfluid helium to bend the path of cosmic particles through a series of detectors, which then measure the mass, speed, charge, and direction of the particles. Four Sunpower M87N Stirling-cycle cryocoolers are used to extend the mission life by cooling the outer vapor-cooled shield of the dewar. The main magnet coils are separated by a distance of approximately 1 m and the coolers are located approximately 1.5 m from the center line of the magnet, where the field is as high as 925 gauss perpendicular to the cryocooler axis and 400 gauss along the cryocooler axis. Interactions between the applied magnetic field and the linear motor may result in additional forces and torques on the compressor piston. Motion of the compressor arid displacer pistons through the magnetic field spatial gradients will generate eddy currents. Additional eddy currents are created during magnet charge, discharge, and quench by the time-varying magnetic field. The results of tests to determine the magnitude of the forces, torques, and heating effects, as well as the need for additional magnetic shielding, are presented.
    Keywords: Engineering (General)
    Type: 12th International Cryocooler Conference; Jun 17, 2002 - Jun 20, 2002; Cambridge, MA; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 5
    facet.materialart.
    Unknown
    Space Flight Qualification Program for the AMS-2 Commercial Cryocoolers (2002)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Alpha Magnetic Spectrometer-02 (AMS-02) experiment is a state-of-the-art particle physics detector containing a large superfluid helium-cooled superconducting magnet. Highly sensitive detector plates inside the magnet measure a particle's speed, momentum, charge, and path. The AMS-02 experiment will study the properties and origin of cosmic particles and nuclei including antimatter and dark matter. AMS-02 will be installed on the International Space Station on Utilization Flight-4. The experiment will be run for at least three years. To extend the life of the stored cryogen and minimize temperature gradients around the magnet, four Stirling-cycle Sunpower M87N cryocoolers will be integrated with AMS-02. The cryocooler cold tip will be connected via a flexible strap to the outer vapor cooled shield of the dewar. Initial thermal analysis shows the lifetime of the experiment is increased by a factor of 2.8 with the use of the cryocooler. The AMS-02 project selected the Sunpower M87 cryocoolers and has asked NASA Goddard to qualify the cryocoolers for space flight use. This paper describes the interfaces with the cryocoolers and presents data collected during testing of the two engineering model cryocoolers. Tests include thermal performance characterization and launch vibration testing. Magnetic field compatibility testing will be presented in a separate paper at the conference.
    Keywords: Engineering (General)
    Type: 12th International Cryocooler Conference (ICC-12); Jun 18, 2002 - Jun 20, 2002; Cambridge, MA; United States
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...