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  • 1
    Publication Date: 2016-06-19
    Description: Article Plasma accelerators driven by particle beams are a promising technology, but the acceleration distance and energy gain are strongly limited by head erosion in a high-ionization-potential gas. Here the authors observe up to 130% energy boost in a self-focused electron beam, with limited head erosion. Nature Communications doi: 10.1038/ncomms11898 Authors: S. Corde, E. Adli, J. M. Allen, W. An, C. I. Clarke, B. Clausse, C. E. Clayton, J. P. Delahaye, J. Frederico, S. Gessner, S. Z. Green, M. J. Hogan, C. Joshi, M. Litos, W. Lu, K. A. Marsh, W. B. Mori, N. Vafaei-Najafabadi, D. Walz, V. Yakimenko
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
    Publication Date: 2014-11-15
    Description: The obligate-heritable endosymbionts of insects possess some of the smallest known bacterial genomes. This is likely due to loss of genomic material during symbiosis. The mode and rate of this erosion may change over evolutionary time: faster in newly formed associations and slower in long-established ones. The endosymbionts of human and anthropoid primate lice present a unique opportunity to study genome erosion in newly established (or young) symbionts. This is because we have a detailed phylogenetic history of these endosymbionts with divergence dates for closely related species. This allows for genome evolution to be studied in detail and rates of change to be estimated in a phylogenetic framework. Here, we sequenced the genome of the chimpanzee louse endosymbiont ( Candidatus Riesia pediculischaeffi) and compared it with the closely related genome of the human body louse endosymbiont. From this comparison, we found evidence for recent genome erosion leading to gene loss in these endosymbionts. Although gene loss was detected, it was not significantly greater than in older endosymbionts from aphids and ants. Additionally, we searched for genes associated with B-vitamin synthesis in the two louse endosymbiont genomes because these endosymbionts are believed to synthesize essential B vitamins absent in the louse’s diet. All of the expected genes were present, except those involved in thiamin synthesis. We failed to find genes encoding for proteins involved in the biosynthesis of thiamin or any complete exogenous means of salvaging thiamin, suggesting there is an undescribed mechanism for the salvage of thiamin. Finally, genes encoding for the pantothenate de novo biosynthesis pathway were located on a plasmid in both taxa along with a heat shock protein. Movement of these genes onto a plasmid may be functionally and evolutionarily significant, potentially increasing production and guarding against the deleterious effects of mutation. These data add to a growing resource of obligate endosymbiont genomes and to our understanding of the rate and mode of genome erosion in obligate animal-associated bacteria. Ultimately sequencing additional louse p-endosymbiont genomes will provide a model system for studying genome evolution in obligate host associated bacteria.
    Electronic ISSN: 2160-1836
    Topics: Biology
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1989-01-20
    Description: Human and murine mononuclear phagocytes express a high-affinity receptor for immunoglobulin G that plays a central role in macrophage antibody-dependent cellular cytotoxicity and clearance of immune complexes. The receptor (FcRI) may also be involved in CD4-independent infection of human macrophages by human immunodeficiency virus. This report describes the isolation of cDNA clones encoding the human FcRI by a ligand-mediated selection technique. Expression of the cDNAs in COS cells gave rise to immunoglobulin G binding of the expected affinity and subtype specificity. RNA blot analysis revealed expression of a 1.7-kilobase transcript in macrophages and in cells of the promonocytic cell line U937 induced with interferon-gamma. The extracellular region of FcRI consists of three immunoglobulin-like domains, two of which share homology with low-affinity receptor domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, J M -- Seed, B -- New York, N.Y. -- Science. 1989 Jan 20;243(4889):378-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2911749" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Blotting, Northern ; Cercopithecus aethiops ; Cloning, Molecular ; DNA/genetics ; Gene Expression Regulation ; Humans ; Molecular Sequence Data ; Molecular Weight ; Polymorphism, Genetic ; Receptors, Fc/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2012-05-25
    Description: Warming experiments are increasingly relied on to estimate plant responses to global climate change. For experiments to provide meaningful predictions of future responses, they should reflect the empirical record of responses to temperature variability and recent warming, including advances in the timing of flowering and leafing. We compared phenology (the timing of recurring life history events) in observational studies and warming experiments spanning four continents and 1,634 plant species using a common measure of temperature sensitivity (change in days per degree Celsius). We show that warming experiments underpredict advances in the timing of flowering and leafing by 8.5-fold and 4.0-fold, respectively, compared with long-term observations. For species that were common to both study types, the experimental results did not match the observational data in sign or magnitude. The observational data also showed that species that flower earliest in the spring have the highest temperature sensitivities, but this trend was not reflected in the experimental data. These significant mismatches seem to be unrelated to the study length or to the degree of manipulated warming in experiments. The discrepancy between experiments and observations, however, could arise from complex interactions among multiple drivers in the observational data, or it could arise from remediable artefacts in the experiments that result in lower irradiance and drier soils, thus dampening the phenological responses to manipulated warming. Our results introduce uncertainty into ecosystem models that are informed solely by experiments and suggest that responses to climate change that are predicted using such models should be re-evaluated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolkovich, E M -- Cook, B I -- Allen, J M -- Crimmins, T M -- Betancourt, J L -- Travers, S E -- Pau, S -- Regetz, J -- Davies, T J -- Kraft, N J B -- Ault, T R -- Bolmgren, K -- Mazer, S J -- McCabe, G J -- McGill, B J -- Parmesan, C -- Salamin, N -- Schwartz, M D -- Cleland, E E -- England -- Nature. 2012 May 2;485(7399):494-7. doi: 10.1038/nature11014.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive 0116, La Jolla, California 92093, USA. wolkovich@biodiversity.ubc.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22622576" target="_blank"〉PubMed〈/a〉
    Keywords: Artifacts ; Ecosystem ; Flowers/growth & development/physiology ; *Global Warming ; *Models, Biological ; *Periodicity ; Plant Development ; Plant Leaves/growth & development/physiology ; *Plant Physiological Phenomena ; Plants/classification ; Reproducibility of Results ; Soil/chemistry ; Temperature ; Time Factors ; *Uncertainty
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1995-06-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, S K -- Allen, J M -- Clark, J H -- Blaustein, J D -- O'Malley, B W -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1833.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/*pharmacology ; Female ; Male ; Neurotransmitter Agents/*physiology ; Rats ; Sexual Behavior, Animal/drug effects/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1994-08-26
    Description: Estrogen and progesterone modulate gene expression in rodents by activation of intracellular receptors in the hypothalamus, which regulate neuronal networks that control female sexual behavior. However, the neurotransmitter dopamine has been shown to activate certain steroid receptors in a ligand-independent manner. A dopamine receptor stimulant and a D1 receptor agonist, but not a D2 receptor agonist, mimicked the effects of progesterone in facilitating sexual behavior in female rats. The facilitory effect of the neurotransmitter was blocked by progesterone receptor antagonists, a D1 receptor antagonist, or antisense oligonucleotides to the progesterone receptor. The results suggest that in rodents neurotransmitters may regulate in vivo gene expression and behavior by means of cross-talk with steroid receptors in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, S K -- Allen, J M -- Clark, J H -- Blaustein, J D -- O'Malley, B W -- MH-00885/MH/NIMH NIH HHS/ -- NS 19327/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 Aug 26;265(5176):1246-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7915049" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/drug effects ; Animals ; Base Sequence ; Benzazepines/pharmacology ; Dopamine/*physiology ; Dopamine Agents/administration & dosage/pharmacology ; Estradiol/analogs & derivatives/pharmacology ; Female ; Hypothalamus/drug effects/*physiology ; Injections, Intraventricular ; Male ; Molecular Sequence Data ; Oligonucleotides, Antisense/pharmacology ; Posture ; Progesterone/pharmacology/*physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Progesterone/genetics/*physiology ; Sexual Behavior, Animal/drug effects/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 1993-04-02
    Description: Gas-to-drop partitioning of hydrogen peroxide and its precursor, the hydroperoxyl radical (HO2.), has been considered the predominant or sole source of hydrogen peroxide in atmospheric water drops. However, atmospheric water can absorb solar ultraviolet radiation, which initiates the photoformation of peroxides (primarily hydrogen peroxide). Measurements of peroxide photoformation rates in authentic atmospheric water samples demonstrate that aqueous-phase photochemical reactions are a significant, and in some cases dominant, source of hydrogen peroxide to cloud and fog drops. This additional source could significantly change the current understanding, and hence, the models, of sulfuric acid deposition because hydrogen peroxide is the limiting reagent in the dominant pathway for the oxidation of sulfur dioxide to sulfuric acid in the troposphere over eastern North America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faust, B C -- Anastasio, C -- Allen, J M -- Arakaki, T -- New York, N.Y. -- Science. 1993 Apr 2;260(5104):73-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University, School of the Environment, Durham, NC 27708.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8465202" target="_blank"〉PubMed〈/a〉
    Keywords: *Atmosphere ; Chemistry, Physical ; Free Radicals ; Hydrogen Peroxide/*chemistry ; Oxidation-Reduction ; Photochemistry ; Physicochemical Phenomena ; Sulfur Dioxide/chemistry ; Sulfuric Acids/chemistry ; Sunlight ; Ultraviolet Rays ; Water/*chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2017-10-03
    Description: Author(s): C. Wrede, B. E. Glassman, D. Pérez-Loureiro, J. M. Allen, D. W. Bardayan, M. B. Bennett, B. A. Brown, K. A. Chipps, M. Febbraro, C. Fry, M. R. Hall, O. Hall, S. N. Liddick, P. O'Malley, W.-J. Ong, S. D. Pain, S. B. Schwartz, P. Shidling, H. Sims, P. Thompson, and H. Zhang The O 15 ( α , γ ) Ne 19 reaction is expected to trigger the initial path for breakout from the CNO hydrogen-burning cycles to the rapid proton capture ( r p ) process in type I x-ray bursts on accreting neutron stars. The thermonuclear reaction rate has a major impact on models of type I x-ray burst observabl... [Phys. Rev. C 96, 032801(R)] Published Fri Sep 29, 2017
    Keywords: Nuclear Astrophysics
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 9
    Publication Date: 1983-08-26
    Description: A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, Y S -- Adrian, T E -- Allen, J M -- Tatemoto, K -- Crow, T J -- Bloom, S R -- Polak, J M -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):877-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6136091" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Nerve Tissue Proteins/immunology/*metabolism ; Neuropeptide Y ; Neurotransmitter Agents/metabolism ; Rats ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2015-08-28
    Description: Electrical breakdown sets a limit on the kinetic energy that particles in a conventional radio-frequency accelerator can reach. New accelerator concepts must be developed to achieve higher energies and to make future particle colliders more compact and affordable. The plasma wakefield accelerator (PWFA) embodies one such concept, in which the electric field of a plasma wake excited by a bunch of charged particles (such as electrons) is used to accelerate a trailing bunch of particles. To apply plasma acceleration to electron-positron colliders, it is imperative that both the electrons and their antimatter counterpart, the positrons, are efficiently accelerated at high fields using plasmas. Although substantial progress has recently been reported on high-field, high-efficiency acceleration of electrons in a PWFA powered by an electron bunch, such an electron-driven wake is unsuitable for the acceleration and focusing of a positron bunch. Here we demonstrate a new regime of PWFAs where particles in the front of a single positron bunch transfer their energy to a substantial number of those in the rear of the same bunch by exciting a wakefield in the plasma. In the process, the accelerating field is altered--'self-loaded'--so that about a billion positrons gain five gigaelectronvolts of energy with a narrow energy spread over a distance of just 1.3 metres. They extract about 30 per cent of the wake's energy and form a spectrally distinct bunch with a root-mean-square energy spread as low as 1.8 per cent. This ability to transfer energy efficiently from the front to the rear within a single positron bunch makes the PWFA scheme very attractive as an energy booster to an electron-positron collider.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corde, S -- Adli, E -- Allen, J M -- An, W -- Clarke, C I -- Clayton, C E -- Delahaye, J P -- Frederico, J -- Gessner, S -- Green, S Z -- Hogan, M J -- Joshi, C -- Lipkowitz, N -- Litos, M -- Lu, W -- Marsh, K A -- Mori, W B -- Schmeltz, M -- Vafaei-Najafabadi, N -- Walz, D -- Yakimenko, V -- Yocky, G -- England -- Nature. 2015 Aug 27;524(7566):442-5. doi: 10.1038/nature14890.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA. ; LOA, ENSTA ParisTech, CNRS, Ecole Polytechnique, Universite Paris-Saclay, 91762 Palaiseau, France. ; Department of Physics, University of Oslo, 0316 Oslo, Norway. ; Department of Electrical Engineering, University of California Los Angeles, Los Angeles, California 90095, USA. ; Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California 90095, USA. ; Department of Engineering Physics, Tsinghua University, Beijing 100084, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26310764" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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