Publication Date:
1986-04-18
Description:
The Hu-ets-1 oncogene was found to be rearranged and amplified 30-fold in one case of acute myelomonocytic leukemia in which a homogeneously staining region occurred on 11q23; the oncogene was rearranged and amplified approximately tenfold in a case of small lymphocytic cell lymphoma with an inverted insertion that also involved band 11q23. This work suggests that Hu-ets-1 is an unusual oncogene that can help explain the common involvement of chromosome band 11q23 in various subtypes of hematopoietic malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rovigatti, U -- Watson, D K -- Yunis, J J -- CA-31024/CA/NCI NIH HHS/ -- CA-33314/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):398-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3457468" target="_blank"〉PubMed〈/a〉
Keywords:
Chromosome Aberrations/genetics
;
Chromosome Banding
;
Chromosome Disorders
;
Chromosome Mapping
;
Chromosomes, Human, 13-15/ultrastructure
;
*Chromosomes, Human, 6-12 and X/ultrastructure
;
DNA, Neoplasm/genetics/isolation & purification
;
Humans
;
Leukemia, Myeloid, Acute/*genetics
;
Lymphoma, Non-Hodgkin/*genetics
;
Nucleic Acid Hybridization
;
*Oncogenes
;
Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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