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  • 1
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    Sequence interpretation. Functional annotation of mouse genome sequences (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, J H -- Balling, R -- Barsh, G -- Beier, D -- Brown, S D -- Bucan, M -- Camper, S -- Carlson, G -- Copeland, N -- Eppig, J -- Fletcher, C -- Frankel, W N -- Ganten, D -- Goldowitz, D -- Goodnow, C -- Guenet, J L -- Hicks, G -- Hrabe de Angelis, M -- Jackson, I -- Jacob, H J -- Jenkins, N -- Johnson, D -- Justice, M -- Kay, S -- Kingsley, D -- Lehrach, H -- Magnuson, T -- Meisler, M -- Poustka, A -- Rinchik, E M -- Rossant, J -- Russell, L B -- Schimenti, J -- Shiroishi, T -- Skarnes, W C -- Soriano, P -- Stanford, W -- Takahashi, J S -- Wurst, W -- Zimmer, A -- International Mouse Mutagenesis Consortium -- New York, N.Y. -- Science. 2001 Feb 16;291(5507):1251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, BRB 624, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. jhn4@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11233449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Computational Biology ; Costs and Cost Analysis ; Genes/physiology ; Genetic Techniques ; *Genome ; *Genomics ; International Cooperation ; Mice/*genetics ; Mutagenesis ; Mutation ; Phenotype ; Private Sector ; Public Sector ; Research Support as Topic ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Finding genes that underlie complex traits (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: Phenotypic variation among organisms is central to evolutionary adaptations underlying natural and artificial selection, and also determines individual susceptibility to common diseases. These types of complex traits pose special challenges for genetic analysis because of gene-gene and gene-environment interactions, genetic heterogeneity, low penetrance, and limited statistical power. Emerging genome resources and technologies are enabling systematic identification of genes underlying these complex traits. We propose standards for proof of gene discovery in complex traits and evaluate the nature of the genes identified to date. These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glazier, Anne M -- Nadeau, Joseph H -- Aitman, Timothy J -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2345-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, Ducane Road, London W12 0NN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493905" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Chromosome Mapping ; Genetic Linkage ; *Genetic Predisposition to Disease ; Genetic Variation ; Humans ; *Multifactorial Inheritance ; Mutation ; Phenotype ; Plants/genetics ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; Saccharomyces cerevisiae/genetics ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Autosomal dominant mutations affecting X inactivation choice in the mouse (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-11
    Description: X chromosome inactivation is the silencing mechanism eutherian mammals use to equalize the expression of X-linked genes between males and females early in embryonic development. In the mouse, genetic control of inactivation requires elements within the X inactivation center (Xic) on the X chromosome that influence the choice of which X chromosome is to be inactivated in individual cells. It has long been posited that unidentified autosomal factors are essential to the process. We have used chemical mutagenesis in the mouse to identify specific factors involved in X inactivation and report two genetically distinct autosomal mutations with dominant effects on X chromosome choice early in embryogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Percec, Ivona -- Plenge, Robert M -- Nadeau, Joseph H -- Bartolomei, Marisa S -- Willard, Huntington F -- GM45441/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 May 10;296(5570):1136-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004136" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Crosses, Genetic ; *Dosage Compensation, Genetic ; Female ; *Genes, Dominant ; Heterozygote ; Male ; Mice ; Mice, Inbred BALB C ; Mutagenesis ; *Mutation ; Pedigree ; Phenotype ; X Chromosome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Genetics. Modifying the message (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, Joseph H -- New York, N.Y. -- Science. 2003 Aug 15;301(5635):927-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA. jhn4@cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12920288" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/*genetics/physiology ; Cloning, Molecular ; Codon, Terminator ; Exons ; Gene Expression Regulation ; Humans ; Ion Transport ; Mice ; Mice, Inbred C57BL ; Mice, Neurologic Mutants ; Mutation ; NAV1.6 Voltage-Gated Sodium Channel ; *Nerve Tissue Proteins ; Nervous System Diseases/*genetics/metabolism ; Phenotype ; RNA Precursors/genetics/metabolism ; *RNA Splicing ; RNA, Messenger/genetics/metabolism ; Sodium/metabolism ; Sodium Channels/*genetics/metabolism ; Transcription, Genetic ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Genetic dissection of complex traits with chromosome substitution strains of mice (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-20
    Description: Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singer, Jonathan B -- Hill, Annie E -- Burrage, Lindsay C -- Olszens, Keith R -- Song, Junghan -- Justice, Monica -- O'Brien, William E -- Conti, David V -- Witte, John S -- Lander, Eric S -- Nadeau, Joseph H -- GM07250/GM/NIGMS NIH HHS/ -- HD07518/HD/NICHD NIH HHS/ -- RR12305/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):445-8. Epub 2004 Mar 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15031436" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/blood ; Animals ; Anxiety/genetics ; *Chromosome Mapping ; Chromosomes, Mammalian/*genetics ; Crosses, Genetic ; Diet ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Male ; Mice ; Mice, Inbred A ; Mice, Inbred C57BL ; Microsatellite Repeats ; Obesity/genetics/physiopathology ; Phenotype ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; Sterols/blood ; Weight Gain
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Genome maps IV 1993. Wall chart (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Copeland, N G -- Gilbert, D J -- Jenkins, N A -- Nadeau, J H -- Eppig, J T -- Maltais, L J -- Miller, J C -- Dietrich, W F -- Steen, R G -- Lincoln, S E -- New York, N.Y. -- Science. 1993 Oct 1;262(5130):67-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Cancer Institute, Frederick MD.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8211131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Mapping ; Genetic Markers ; *Genome ; Genome, Human ; Humans ; Mice/*genetics ; Mice, Inbred Strains/genetics ; Sequence Homology, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    A database for mouse development (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ringwald, M -- Baldock, R -- Bard, J -- Kaufman, M -- Eppig, J T -- Richardson, J E -- Nadeau, J H -- Davidson, D -- MC_U127527203/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 1994 Sep 30;265(5181):2033-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jackson Laboratory, Bar Harbor, ME 04609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8091224" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Computer Communication Networks ; *Databases, Factual ; Embryonic and Fetal Development ; *Gene Expression ; Mice/embryology/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Genetics. Systems genetics (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-26
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042627/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042627/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, Joseph H -- Dudley, Aimee M -- DP1 HD075624/HD/NICHD NIH HHS/ -- P40 RR012305/RR/NCRR NIH HHS/ -- P50 GM076547/GM/NIGMS NIH HHS/ -- P50GM076547/GM/NIGMS NIH HHS/ -- R01 GM089978/GM/NIGMS NIH HHS/ -- R01GM089978/GM/NIGMS NIH HHS/ -- RR12305/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1015-6. doi: 10.1126/science.1203869.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA. jnadeau@systemsbiology.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease/*genetics ; Gene Expression ; *Genetic Phenomena ; Genetic Techniques ; *Genetics ; Human Genome Project ; Humans ; Phenotype ; *Physiological Phenomena ; Quantitative Trait Loci ; *Systems Biology/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
    Electronic Resource
    Electronic Resource
    Wild-derived alleles of five allozyme-encoding loci in B10.W mice (1981)
    Springer
    Immunogenetics 13 (1981), S. 173-176 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00524614
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  • 10
    Electronic Resource
    Electronic Resource
    Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man (1981)
    Springer
    Biochemical genetics 19 (1981), S. 465-474 
    Details
    ISSN: 1573-4927
    Keywords: phosphoglucomutase ; homology ; linkage ; house mouse ; major histocompatability complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The discovery of a third phosphoglucomutase locus (Pgm-3) in the house mouse is reported. Three alleles are recognized on the basis of differences in electrophoretic mobility and enzymatic activity. Pgm-3 a (fast mobility and high activity) is present in inbred strain C57BL/10J and 24 other strains; Pgm-3 b (slow mobility and high activity) is present in LP/Pas and six other strains; and Pgm-3 c (no detectable activity in any tissue tested) is present in strain DBA/2J and 14 other strains. Seventy-four recombinant inbred strains derived from progenitors that differed at Pgm-3 were used to study genic linkage. Pgm-3 is on chromosome 9 and is linked to Sep-1, d, Mod-1, and Ltw-3. Gene order and recombination frequencies are estimated as d 3.8±1.8% Pgm-3 2.3±1.2% Mod-1. Substrate specificities and cofactor requirements show that mouse Pgm-1 is homologous with human Pgm-2, mouse Pgm-2 with human Pgm-1, and mouse Pgm-3 with human Pgm-3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484619
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