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  • 1
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    TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-03-01
    Description: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function of TDP-43 in the nervous system is uncertain, and a mechanistic role in neurodegeneration remains speculative. We identified neighboring mutations in a highly conserved region of TARDBP in sporadic and familial ALS cases. TARDBPM337V segregated with disease within one kindred and a genome-wide scan confirmed that linkage was restricted to chromosome 1p36, which contains the TARDBP locus. Mutant forms of TDP-43 fragmented in vitro more readily than wild type and, in vivo, caused neural apoptosis and developmental delay in the chick embryo. Our evidence suggests a pathophysiological link between TDP-43 and ALS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sreedharan, Jemeen -- Blair, Ian P -- Tripathi, Vineeta B -- Hu, Xun -- Vance, Caroline -- Rogelj, Boris -- Ackerley, Steven -- Durnall, Jennifer C -- Williams, Kelly L -- Buratti, Emanuele -- Baralle, Francisco -- de Belleroche, Jacqueline -- Mitchell, J Douglas -- Leigh, P Nigel -- Al-Chalabi, Ammar -- Miller, Christopher C -- Nicholson, Garth -- Shaw, Christopher E -- G0500289/Medical Research Council/United Kingdom -- G0501573/Medical Research Council/United Kingdom -- G0600974/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1668-72. doi: 10.1126/science.1154584. Epub 2008 Feb 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Neuroscience, King's College London, Medical Research Council (MRC) Centre for Neurodegeneration Research, and Institute of Psychiatry, London, SE5 8AF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309045" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amino Acid Sequence ; Amino Acid Substitution ; Amyotrophic Lateral Sclerosis/*genetics ; Animals ; Apoptosis ; CHO Cells ; Chick Embryo ; Chromosomes, Human, Pair 1/genetics ; Cricetinae ; Cricetulus ; DNA-Binding Proteins/chemistry/*genetics/physiology ; Embryonic Development ; Female ; Humans ; Male ; Microsatellite Repeats ; Middle Aged ; Molecular Sequence Data ; Mutant Proteins/chemistry/physiology ; *Mutation, Missense ; Neurons/cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Unsymmetrical bis-phosphorus ligands. 9. Group VI metal carbonyl complexes and other derivatives of various (phosphinomethyl)phosphine sulfides (1977)
    s.l. : American Chemical Society
    Inorganic chemistry 16 (1977), S. 1762-1770 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50173a037
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  • 3
    Electronic Resource
    Electronic Resource
    Unsymmetrical bis-phosphorus ligands. 11. Group VI metal carbonyl derivatives of 1-(diphenylphosphino)-3-(alkylphenylphosphino)propane (1977)
    s.l. : American Chemical Society
    Inorganic chemistry 16 (1977), S. 1776-1779 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50173a039
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  • 4
    Electronic Resource
    Electronic Resource
    Unsymmetrical bis-phosphorus ligands. 10. Synthesis and Group VI metal carbonyl derivatives of (diphenylphosphino)(diorganophosphino)methane, Ph2PCH2PR1R2 (1977)
    s.l. : American Chemical Society
    Inorganic chemistry 16 (1977), S. 1770-1776 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50173a038
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  • 5
    Electronic Resource
    Electronic Resource
    Isobutylidene diurea and other nitrogen fertilizers for seedlings and transplants ofPicea sitchensis in two English forest nurseries (1971)
    Springer
    Plant and soil 35 (1971), S. 517-532 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Three slow-release nitrogen fertilizers — medium- and coarse-sized granules of IBDU (isobutylidene diurea) and formalized casein — were applied before sowing or transplanting to Sitka sprucePicea sitchensis, and their effects on growth compared with that on plots not given N or given four topdressings of ‘Nitro-Chalk’ (the source of N used in practice). The comparisons were made at two sites: a very sandy podsol and a sandy loam with better nutrient retention. The experiments with seedlings were continued for four years, those with transplants for three, and the same treatments were applied to the same plots each year. Responses to ‘Nitro-Chalk’ were large, especially during wet seasons. Formalized casein was always as effective as ‘Nitro-Chalk’ for transplants. IBDU (especially the coarse fraction) was almost as good as formalized casein for transplants at both sites and equalled it for seedlings on the sandy loam. For seedlings on the sandy podsol, both particle sizes of IBDU became steadily less effective in succeeding years, and no satisfactory reason can be offered for this decline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01372684
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  • 6
    Electronic Resource
    Electronic Resource
    Growth and uptake of nitrogen by wheat and ryegrass in fumigated and irradiated soil (1972)
    Springer
    Plant and soil 36 (1972), S. 149-158 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Wheat and ryegrass were grown in pots containing soil that had either been irradiated, fumigated with methyl bromide, fumigated with formaldehyde, or left untreated. All pots received a basal dressing of potassium, phosphorus and magnesium; response to nitrogen was tested by applying either 0, 0.177 or 0.354 g nitrogen per pot. Irradiation increased the growth of wheat and ryegrass; uptake of nitrogen was also increased in both crops. The amount of fertilizer nitrogen equivalent to the nitrogen supplied by seeds and soil (the “N value”) can be calculated from the efficiency of uptake of fertilizer nitrogen and used to allow for the effect on crop growth of the nitrogen released by irradiated soil. With wheat the increase in growth can be attributed solely to the extra mineral nitrogen released by irradiated soil. However, ryegrass grew a little better than would have been expected if the only effect of irradiation was to increase the release of soil nitrogen. Fumigation with methyl bromide or formaldehyde increased the growth of wheat and ryegrass not given fertilizer nitrogen. However, fumigation with methyl bromide left ionic bromide in the soil, and this depressed the growth of wheat receiving fertilizer nitrogen. Formaldehyde also left residues; these influenced soil metabolism and sometimes depressed the growth of plants given fertilizer nitrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01373465
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  • 7
    Electronic Resource
    Electronic Resource
    Growth and uptake of nitrogen by wheat and ryegrass in fumigated and irradiated soil (1972)
    Springer
    Plant and soil 36 (1972), S. 149-158 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Wheat and ryegrass were grown in pots containing soil that had either been irradiated, fumigated with methyl bromide, fumigated with formaldehyde, or left untreated. All pots received a basal dressing of potassium, phosphorus and magnesium; response to nitrogen was tested by applying either 0, 0.177 or 0.354 g nitrogen per pot. Irradiation increased the growth of wheat and ryegrass; uptake of nitrogen was also increased in both crops. The amount of fertilizer nitrogen equivalent to the nitrogen supplied by seeds and soil (the “N value”) can be calculated from the efficiency of uptake of fertilizer nitrogen and used to allow for the effect on crop growth of the nitrogen released by irradiated soil. With wheat the increase in growth can be attributed solely to the extra mineral nitrogen released by irradiated soil. However, ryegrass grew a little better than would have been expected if the only effect of irradiation was to increase the release of soil nitrogen. Fumigation with methyl bromide or formaldehyde increased the growth of wheat and ryegrass not given fertilizer nitrogen. However, fumigation with methyl bromide left ionic bromide in the soil, and this depressed the growth of wheat receiving fertilizer nitrogen. Formaldehyde also left residues; these influenced soil metabolism and sometimes depressed the growth of plants given fertilizer nitrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01373465
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  • 8
    Electronic Resource
    Electronic Resource
    Isobutylidene diurea and other nitrogen fertilizers for seedlings and transplants ofPicea sitchensis in two English forest nurseries (1971)
    Springer
    Plant and soil 35 (1971), S. 517-532 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Three slow-release nitrogen fertilizers — medium- and coarse-sized granules of IBDU (isobutylidene diurea) and formalized casein — were applied before sowing or transplanting to Sitka sprucePicea sitchensis, and their effects on growth compared with that on plots not given N or given four topdressings of ‘Nitro-Chalk’ (the source of N used in practice). The comparisons were made at two sites: a very sandy podsol and a sandy loam with better nutrient retention. The experiments with seedlings were continued for four years, those with transplants for three, and the same treatments were applied to the same plots each year. Responses to ‘Nitro-Chalk’ were large, especially during wet seasons. Formalized casein was always as effective as ‘Nitro-Chalk’ for transplants. IBDU (especially the coarse fraction) was almost as good as formalized casein for transplants at both sites and equalled it for seedlings on the sandy loam. For seedlings on the sandy podsol, both particle sizes of IBDU became steadily less effective in succeeding years, and no satisfactory reason can be offered for this decline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01372684
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  • 9
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    Universal sequences for the order-automorphisms of the rationals (2016)
    Oxford University Press
    Details
    Publication Date: 2016-07-29
    Description: In this paper, we consider the group $ \hbox {Aut}( \mathbb {Q}, \leq )$ of order-automorphisms of the rational numbers, proving a result analogous to a theorem of Galvin's for the symmetric group. In an announcement, Khélif states that every countable subset of $ \hbox {Aut}( \mathbb {Q}, \leq )$ is contained in an $N$ -generated subgroup of $ \hbox {Aut}( \mathbb {Q}, \leq )$ for some fixed $N\in \mathbb {N}$ . We show that the least such $N$ is 2. Moreover, for every countable subset of $ \hbox {Aut}( \mathbb {Q}, \leq )$ , we show that every element can be given as a prescribed product of two generators without using their inverses. More precisely, suppose that $a$ and $b$ freely generate the free semigroup $\{a,b\}^+$ consisting of the non-empty words over $a$ and $b$ . Then we show that there exists a sequence of words $w_1, w_2,\ldots $ over $\{a,b\}$ such that for every sequence $f_1, f_2, \ldots \in \hbox {Aut}( \mathbb {Q}, \leq )$ there is a homomorphism $\phi :\{a,b\}^{+}\to \hbox {Aut}( \mathbb {Q}, \leq )$ where $(w_i)\phi =f_i$ for every $i$ . As a corollary to the main theorem in this paper, we obtain a result of Droste and Holland showing that the strong cofinality of $ \hbox {Aut}( \mathbb {Q}, \leq )$ is uncountable, or equivalently that $ \hbox {Aut}( \mathbb {Q}, \leq )$ has uncountable cofinality and Bergman's property.
    Print ISSN: 0024-6107
    Electronic ISSN: 1469-7750
    Topics: Mathematics
    Published by Oxford University Press
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  • 10
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    A quantitative comparison of the diets of sympatric pelagic sharks in gulf and shelf ecosystems off southern Australia (2012)
    Oxford University Press
    Details
    Publication Date: 2012-08-22
    Description: Rogers, P. J., Huveneers, C., Page, B., Hamer, D. J., Goldsworthy, S. D., Mitchell, J. G., and Seuront, L. 2012. A quantitative comparison of the diets of sympatric pelagic sharks in gulf and shelf ecosystems off southern Australia. – ICES Journal of Marine Science, 69: . Predator–prey dynamics represent an important determinant in the functioning of marine ecosystems. This study provides the first quantitative investigation of the diets of sympatric pelagic shark species in gulf and shelf waters off southern Australia. Stomachs of 417 sharks collected from fishery catches between 2007 and 2011 were examined, including 250 bronze whalers, 52 shortfin makos, 49 dusky sharks, 39 smooth hammerheads, and 27 common threshers. Dusky sharks had the highest dietary diversity of the five species examined. We found overlap in the consumption of cephalopods, small pelagic teleosts, crustaceans, and benthic teleosts in bronze whalers, dusky sharks, and smooth hammerheads, and preliminary evidence of specialization in the highly migratory species, the common thresher and the shortfin mako. Findings were discussed and compared with previous studies in other temperate marine ecosystems. This study will significantly improve the understanding of the ecological roles of these top predators in the gulf and shelf habitats off southern Australia, and enhance the ecosystem models being developed for this unique bioregion.
    Print ISSN: 1054-3139
    Electronic ISSN: 1095-9289
    Topics: Biology , Geosciences , Physics
    Published by Oxford University Press
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