Publication Date:
1997-03-14
Description:
In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, X -- Saint-Jeannet, J P -- Wang, Y -- Nathans, J -- Dawid, I -- Varmus, H -- New York, N.Y. -- Science. 1997 Mar 14;275(5306):1652-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Cancer Institute, Building 49, Room 4A56, National Institutes of Health, Bethesda, MD 20892, USA. xhe.nhgri.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9054360" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/metabolism
;
DNA-Binding Proteins/genetics
;
*Drosophila Proteins
;
*Embryonic Development
;
*Embryonic Induction
;
Frizzled Receptors
;
Glycogen Synthase Kinase 3
;
Glycogen Synthase Kinases
;
Goosecoid Protein
;
*Homeodomain Proteins
;
Humans
;
Ligands
;
Membrane Proteins/chemistry/genetics/*metabolism
;
Proteins/genetics/*metabolism
;
Receptors, Cell Surface/genetics/*metabolism
;
Receptors, G-Protein-Coupled
;
*Repressor Proteins
;
Signal Transduction
;
*Transcription Factors
;
Wnt Proteins
;
*Xenopus Proteins
;
Xenopus laevis/embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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