Publication Date:
1989-01-13
Description:
The c-myc protooncogene in mouse embryos was shown by RNA in situ hybridization to be preferentially expressed in tissues of endodermal and mesodermal origin. Most organs developing from the ectoderm, such as skin, brain, and spinal cord, displayed low levels of c-myc RNA. The thymus represented the only hematopoietic organ with high c-myc expression. In organs and structures strongly hybridizing to c-myc probes, for example the fetal part of the placenta, gut, liver, kidney, pancreas, submandibular glands, enamel organs of the molars, and skeletal cartilage, the level of expression depended on the stage of development. Expression was observed to be correlated with proliferation, particularly during expansion and folding of partially differentiated epithelial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmid, P -- Schulz, W A -- Hameister, H -- New York, N.Y. -- Science. 1989 Jan 13;243(4888):226-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Abteilung Klinische Genetik, Universitat Ulm, Federal Republic of Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2911736" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Embryo, Mammalian/*physiology
;
Embryonic and Fetal Development
;
Mice
;
Nucleic Acid Hybridization
;
Organ Specificity
;
*Proto-Oncogenes
;
RNA Probes
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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