ISSN:
1432-0827
Keywords:
Streptococci
;
Cell walls
;
Bone resorption
;
Protein
;
DNA synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Summary Cell wall components fromStreptococcus mutans NCTC 10449 andStreptococcus sanguis ATCC 10558 stimulated the release of45Ca from prelabeled mouse calvariae in organ culture. Bone resorbing activity was not blocked by fetal calf serum. It was, however, blocked by calcitonin, an inhibitor of osteoclast-mediated bone resorption. Indomethacin, a prostaglandin synthetase inhibitor, partially blocked endogenous but not antigen-stimulated45Ca release, suggesting that antigen-stimulated bone resorption was not mediated by prostaglandins. The antigen preparations also had an inhibitory effect on the incorporation of3H-proline and3H-thymidine into explants of rabbit and rat calvariae, respectively. The inhibitory effect of antigen on3H-proline incorporation was not altered by the presence of calcitonin, which suggests that it represented a real inhibition of protein synthesis and not a reflection that the bones were resorbing. These findings indicate that plaque bacterial antigens may contribute directly to the progressive loss of alveolar bone during periodontal disease. The assumption that only Gram-negative organisms play an important role in the etiology of periodontal disease appears incorrect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02411268
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