ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Lake trout samples from the Great Lakes contain residues of a complex pattern of chlorinated bornanes similar to the insecticide toxaphene. These residues, although structurally similar to toxaphene, are composed of a different profile of compounds than the analytical standard. Chlorinated bornane residues were isolated from tissues of Lake Michigan and Siskiwit Lake (Isle Royale) lake trout using a variety of purification techniques. Toxicity studies were conducted to determine the toxicological properties of the isolated residues in comparison to both technical material and the procedural standard. Static 24-hr acute bioassays with mosquito larvae(Aedes egypti) demonstrated that the residues were as toxic as the toxaphene standard. Additionally, experiments performed on the picrotoxinin receptor of the GABA (γ-aminobutyric acid)-chloride ionophore complex of the central nervous system revealed that the residues were very potent at the [35S]-t-butylbicyclophosphorothionate binding site. Therefore, both non-specific and specific measures of toxicologic potency show that environmentally derived residues of toxaphene retain significant biologic activity. There is no trend for decreasing toxicity of toxaphene residues for the period of 1982–85. Also, the residues found in samples from Siskiwit Lake were as toxic as those found in Lake Michigan.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01054953
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