Publication Date:
1978-07-21
Description:
The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wise, R A -- Spindler, J -- deWit, H -- Gerberg, G J -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):262-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566469" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Conditioning, Operant/drug effects
;
Food
;
Humans
;
Parkinson Disease/physiopathology
;
Pimozide/*pharmacology
;
Rats
;
Receptors, Dopamine/drug effects
;
*Reward
;
Schizophrenia/physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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