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  • 1
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    astray, a zebrafish roundabout homolog required for retinal axon guidance (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-21
    Description: As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection. Eye transplantation experiments show that astray function is required in the eye. We identify astray as zebrafish robo2, a member of the Roundabout family of axon guidance receptors. Retinal ganglion cells express robo2 as they extend axons. Thus, robo2 is required for multiple axon guidance decisions during establishment of the vertebrate visual projection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fricke, C -- Lee, J S -- Geiger-Rudolph, S -- Bonhoeffer, F -- Chien, C B -- R01-EY12873/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 20;292(5516):507-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, University of Utah Medical Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11313496" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Axons/*physiology ; Body Patterning ; Chromosome Mapping ; Crosses, Genetic ; Eye/embryology/transplantation ; Female ; Gene Expression Regulation, Developmental ; Genes ; In Situ Hybridization ; Male ; Mutation ; Nerve Tissue Proteins/*genetics/physiology ; Phenotype ; Receptors, Immunologic/*genetics/*physiology ; Retina/embryology/metabolism ; Retinal Ganglion Cells/metabolism/*physiology ; Superior Colliculi/cytology/*embryology ; Visual Pathways/embryology ; Zebrafish/embryology/genetics ; Zebrafish Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Axon guidance by gradients of a target-derived component (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-01-24
    Description: Spatial gradients of axon guiding molecules have long been suspected to provide positional and directional cues for retinal ganglion cell axons growing within the optic tectum. With the identification of a guiding activity from tectal cell membranes, it has become possible to investigate the potential physiological significance of molecular gradients for retinal growth cone behavior in vitro. A subset of retinal growth cones, those from the temporal half, were highly sensitive to small concentration changes of the guiding component. The degree of response was correlated with the strength of the gradient. These findings demonstrate that the neural growth cone can read gradients of surface-associated information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baier, H -- Bonhoeffer, F -- New York, N.Y. -- Science. 1992 Jan 24;255(5043):472-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1734526" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Cell Membrane/physiology ; Chick Embryo ; Culture Techniques ; Retina/*cytology ; Superior Colliculi/*physiology/ultrastructure ; Visual Pathways/*cytology/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Attractive axon guidance molecules (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baier, H -- Bonhoeffer, F -- New York, N.Y. -- Science. 1994 Sep 9;265(5178):1541-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8079167" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Caenorhabditis elegans ; *Caenorhabditis elegans Proteins ; Cell Movement ; Chick Embryo ; Cloning, Molecular ; Helminth Proteins/genetics/metabolism ; Nerve Growth Factors/chemistry/genetics/*physiology ; *Nerve Tissue Proteins ; Rats ; Tumor Suppressor Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Using an Epidemiological Model for Phylogenetic Inference Reveals Density Dependence in HIV Transmission (2014)
    Oxford University Press
    Details
    Publication Date: 2014-01-04
    Description: The control, prediction, and understanding of epidemiological processes require insight into how infectious pathogens transmit in a population. The chain of transmission can in principle be reconstructed with phylogenetic methods which analyze the evolutionary history using pathogen sequence data. The quality of the reconstruction, however, crucially depends on the underlying epidemiological model used in phylogenetic inference. Until now, only simple epidemiological models have been used, which make limiting assumptions such as constant rate parameters, infinite total population size, or deterministically changing population size of infected individuals. Here, we present a novel phylogenetic method to infer parameters based on a classical stochastic epidemiological model. Specifically, we use the susceptible-infected-susceptible model, which accounts for density-dependent transmission rates and finite total population size, leading to a stochastically changing infected population size. We first validate our method by estimating epidemic parameters for simulated data and then apply it to transmission clusters from the Swiss HIV epidemic. Our estimates of the basic reproductive number R 0 for the considered Swiss HIV transmission clusters are significantly higher than previous estimates, which were derived assuming infinite population size. This difference in key parameter estimates highlights the importance of careful model choice when doing phylogenetic inference. In summary, this article presents the first fully stochastic implementation of a classical epidemiological model for phylogenetic inference and thereby addresses a key aspect in ongoing efforts to merge phylogenetics and epidemiology.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
    Published by Oxford University Press
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  • 5
    Electronic Resource
    Electronic Resource
    Replication of the Bacterial Chromosome (1969)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 3 (1969), S. 233-246 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ge.03.120169.001313
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  • 6
    Electronic Resource
    Electronic Resource
    DNA Replication (1972)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 41 (1972), S. 301-332 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.41.070172.001505
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  • 7
    Electronic Resource
    Electronic Resource
    The fate of the protein component of bacteriophage fd during infection
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 28 (1967), S. 932-939 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(67)90069-1
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  • 8
    Electronic Resource
    Electronic Resource
    Studies on the organization of nucleic acids within nucleoproteins
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 2 (1960), S. 366-371 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(60)90036-X
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  • 9
    Electronic Resource
    Electronic Resource
    Monoclonal antibodies against chromosomal proteins of Drosophila melanogaster (1980)
    Springer
    Chromosoma 80 (1980), S. 253-275 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Total nuclear protein from the embryonic D. melanogaster cell line Kc and crude hydroxyapatite fractions thereof were used for immunization of mice. From the spleen cells of these mice we established 755 permanent lymphoid cell lines using the hybridoma technique originally developed by Köhler and Milstein (1975). Radioimmunoassay showed 455 of these cell lines secreted antibodies which bound to component(s) contained in the antigen mixtures used for immunization. Screening of 311 cell lines using indirect immunofluorescence revealed 58 lines whose antibodies showed a highly selective staining pattern on polytene chromosomes from the salivary glands of D. melanogaster third instar larvae. Eight of these cell lines were cloned and further characterized. We were able to order the staining patterns into three distinct classes based on the staining behaviour of the monoclonal antibodies: staining of active regions, staining of phase dark bands or staining of most interbands. The molecular weight of those antigens against which the monoclonal antibodies were directed was determined in SDS polyacrylamide gels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292684
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  • 10
    Electronic Resource
    Electronic Resource
    Die Partial-Beta-Spektren des Dy165 (1959)
    Springer
    The European physical journal 155 (1959), S. 488-497 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Das Spektrum der auf denZerfall des66Dy165 (2,3 h) folgendenγ- Quanten wurde mit einem Szintillationsspektrometer gemessen. Außer den bisher bekannten Linien, deren Energien zu 95, 275, 356, 630, 708 und 985 keV bestimmt wurden, wurde eine weitere bei (555±5) keV gefunden. Durchβ- γ- Koinzidenzen wurden die zum 95 keV- und zum 985 keV-Niveau führendenβ-Übergänge mit dem Szintillationsspektrometer untersucht. Die Messung derβ- Spektren erfolgte dabei mit einem Anthracen-Spaltkristall, der von einem Na J-Lochkristall umgeben war, um damit die zur Koinzidenz benutztenγ- Quanten zu registrieren. Die Form beiderβ-Spektren wurde zum ersten Male bestimmt, die Fermi-Diagramme zeigen in jedem Falle einen geradlinigen Verlauf. Als Maximalenergien ergaben sich (1,215±0,020) und (0,305±0,010) MeV. Für die Maximalenergie des zum Grundniveau des Ho165 führendenβ-Überganges ergab sich (1,305±0,020).MeV. Ausβ-γ-Koinzidenzmessungen und den Intensitätsverhältnissen desγ-Spektrums geht hervor, daß der Zerfall des Dy165 zu 80% in das Grundniveau des Ho163 erfolgt, 16% der Zerfälle führen zum 95 keV-Niveau und etwa 2% zum 985 keV-Niveau.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01333130
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