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  • 1
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    SIVcpz in wild chimpanzees (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-01-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santiago, Mario L -- Rodenburg, Cynthia M -- Kamenya, Shadrack -- Bibollet-Ruche, Frederic -- Gao, Feng -- Bailes, Elizabeth -- Meleth, Sreelatha -- Soong, Seng-Jaw -- Kilby, J Michael -- Moldoveanu, Zina -- Fahey, Babette -- Muller, Martin N -- Ayouba, Ahidjo -- Nerrienet, Eric -- McClure, Harold M -- Heeney, Jonathan L -- Pusey, Anne E -- Collins, D Anthony -- Boesch, Christophe -- Wrangham, Richard W -- Goodall, Jane -- Sharp, Paul M -- Shaw, George M -- Hahn, Beatrice H -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):465.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Alabama at Birmingham, Birmingham, AL 35294-6024, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799233" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild/*virology ; Antibodies, Viral/analysis/urine ; Ape Diseases/*epidemiology ; Cote d'Ivoire/epidemiology ; Feces/virology ; HIV-1/genetics ; Immunoblotting ; Male ; Pan troglodytes/immunology/*virology ; Polymerase Chain Reaction ; Prevalence ; RNA, Viral/analysis ; Simian Acquired Immunodeficiency Syndrome/*epidemiology ; Simian Immunodeficiency Virus/genetics/immunology/*isolation & purification ; Tanzania/epidemiology ; Uganda/epidemiology ; Urine/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-27
    Description: Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Derdeyn, Cynthia A -- Decker, Julie M -- Bibollet-Ruche, Frederic -- Mokili, John L -- Muldoon, Mark -- Denham, Scott A -- Heil, Marintha L -- Kasolo, Francis -- Musonda, Rosemary -- Hahn, Beatrice H -- Shaw, George M -- Korber, Bette T -- Allen, Susan -- Hunter, Eric -- AI-40951/AI/NIAID NIH HHS/ -- AI-51231/AI/NIAID NIH HHS/ -- N01-85338/PHS HHS/ -- U01-AI-41530/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 26;303(5666):2019-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15044802" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines ; Amino Acid Sequence ; Cohort Studies ; Epitopes/immunology ; Female ; Genes, env ; Glycosylation ; HIV Antibodies/*immunology ; HIV Envelope Protein gp120/chemistry/genetics/*immunology ; HIV Infections/*immunology/*transmission/virology ; HIV-1/genetics/*immunology/physiology ; Heterosexuality ; Humans ; Likelihood Functions ; Male ; Molecular Sequence Data ; Neutralization Tests ; Prospective Studies ; Viral Load ; Zambia
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Hybrid origin of SIV in chimpanzees (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailes, Elizabeth -- Gao, Feng -- Bibollet-Ruche, Frederic -- Courgnaud, Valerie -- Peeters, Martine -- Marx, Preston A -- Hahn, Beatrice H -- Sharp, Paul M -- N01 AI85338/AI/NIAID NIH HHS/ -- R01 AI44596/AI/NIAID NIH HHS/ -- R01 AI50529/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2003 Jun 13;300(5626):1713.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Nottingham, Nottingham NG72UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12805540" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ape Diseases/transmission/*virology ; Cercocebus/virology ; Cercopithecinae/*virology ; Cercopithecus/virology ; Genetic Variation ; Likelihood Functions ; Pan troglodytes/classification/physiology/*virology ; Phylogeny ; Predatory Behavior ; Proteome ; *Recombination, Genetic ; Simian Acquired Immunodeficiency Syndrome/transmission/*virology ; Simian Immunodeficiency Virus/classification/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Chimpanzee reservoirs of pandemic and nonpandemic HIV-1 (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-05-27
    Description: Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442710/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442710/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keele, Brandon F -- Van Heuverswyn, Fran -- Li, Yingying -- Bailes, Elizabeth -- Takehisa, Jun -- Santiago, Mario L -- Bibollet-Ruche, Frederic -- Chen, Yalu -- Wain, Louise V -- Liegeois, Florian -- Loul, Severin -- Ngole, Eitel Mpoudi -- Bienvenue, Yanga -- Delaporte, Eric -- Brookfield, John F Y -- Sharp, Paul M -- Shaw, George M -- Peeters, Martine -- Hahn, Beatrice H -- P30 AI 27767/AI/NIAID NIH HHS/ -- R01 AI058715/AI/NIAID NIH HHS/ -- R01 AI058715-05/AI/NIAID NIH HHS/ -- R01 AI50529/AI/NIAID NIH HHS/ -- R01 AI58715/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 28;313(5786):523-6. Epub 2006 May 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16728595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/analysis ; Ape Diseases/epidemiology/virology ; Cameroon/epidemiology ; DNA, Mitochondrial/genetics ; *Disease Outbreaks ; *Disease Reservoirs ; Feces/virology ; HIV Antibodies/analysis ; HIV Infections/epidemiology/*virology ; HIV-1/classification/*genetics ; Haplotypes ; Humans ; Molecular Epidemiology ; Molecular Sequence Data ; Pan troglodytes/classification/*virology ; Phylogeny ; Prevalence ; Recombination, Genetic ; Simian Acquired Immunodeficiency Syndrome/epidemiology/*virology ; Simian Immunodeficiency Virus/classification/*genetics/immunology/isolation & ; purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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