Publication Date:
2011-07-02
Description:
Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Viviani, Daniele -- Charlet, Alexandre -- van den Burg, Erwin -- Robinet, Camille -- Hurni, Nicolas -- Abatis, Marios -- Magara, Fulvio -- Stoop, Ron -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):104-7. doi: 10.1126/science.1201043.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital Center, University of Lausanne, CH-1015 Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719680" target="_blank"〉PubMed〈/a〉
Keywords:
Amygdala/*physiology
;
Animals
;
Bombesin/pharmacology
;
Brain Stem/*physiology
;
Conditioning (Psychology)
;
Fear/*physiology
;
Female
;
GABA-A Receptor Agonists/pharmacology
;
Heart Rate/drug effects
;
Hypothalamus/*physiology
;
Male
;
Muscimol/pharmacology
;
Neural Inhibition
;
Neural Pathways/physiology
;
Neurons/*physiology
;
Oxytocin/agonists/analogs & derivatives/pharmacology/*physiology
;
Patch-Clamp Techniques
;
Periaqueductal Gray/*physiology
;
Rats
;
Rats, Sprague-Dawley
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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