ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-20
    Description: The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a mismatched CpG site in vitro. These properties suggest that MBD4 might function in vivo to minimize the mutability of 5-methylcytosine by removing its deamination product from DNA. We tested this hypothesis by analyzing Mbd4-/- mice and found that the frequency of of C --〉 T transitions at CpG sites was increased by a factor of three. On a cancer-susceptible Apc(Min/+) background, Mbd4-/- mice showed accelerated tumor formation with CpG --〉 TpG mutations in the Apc gene. Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millar, Catherine B -- Guy, Jacky -- Sansom, Owen J -- Selfridge, Jim -- MacDougall, Eilidh -- Hendrich, Brian -- Keightley, Peter D -- Bishop, Stefan M -- Clarke, Alan R -- Bird, Adrian -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):403-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for Cell Biology, The King's Buildings, Edinburgh University, Edinburgh EH9 3JR, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130785" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Alleles ; Amino Acid Sequence ; Animals ; Base Pair Mismatch ; Cytosine/*analogs & derivatives/metabolism ; DNA Methylation ; DNA Repair ; Deamination ; Dinucleoside Phosphates/*genetics ; Endodeoxyribonucleases/*genetics/*physiology ; Female ; Gene Targeting ; Genes, APC ; Genetic Predisposition to Disease ; Intestinal Neoplasms/etiology/*genetics ; Intestine, Large ; Loss of Heterozygosity ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; *Point Mutation ; Suppression, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-02-01
    Description: Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired with guanine, it was proposed to act against the mutability of 5-methylcytosine (5-mC) deamination in mammalian DNA. However, TDG was also found to interact with transcription factors, histone acetyltransferases and de novo DNA methyltransferases, and it has been associated with DNA demethylation in gene promoters following activation of transcription, altogether implicating an engagement in gene regulation rather than DNA repair. Here we use a mouse genetic approach to determine the biological function of this multifaceted DNA repair enzyme. We find that, unlike other DNA glycosylases, TDG is essential for embryonic development, and that this phenotype is associated with epigenetic aberrations affecting the expression of developmental genes. Fibroblasts derived from Tdg null embryos (mouse embryonic fibroblasts, MEFs) show impaired gene regulation, coincident with imbalanced histone modification and CpG methylation at promoters of affected genes. TDG associates with the promoters of such genes both in fibroblasts and in embryonic stem cells (ESCs), but epigenetic aberrations only appear upon cell lineage commitment. We show that TDG contributes to the maintenance of active and bivalent chromatin throughout cell differentiation, facilitating a proper assembly of chromatin-modifying complexes and initiating base excision repair to counter aberrant de novo methylation. We thus conclude that TDG-dependent DNA repair has evolved to provide epigenetic stability in lineage committed cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cortazar, Daniel -- Kunz, Christophe -- Selfridge, Jim -- Lettieri, Teresa -- Saito, Yusuke -- MacDougall, Eilidh -- Wirz, Annika -- Schuermann, David -- Jacobs, Angelika L -- Siegrist, Fredy -- Steinacher, Roland -- Jiricny, Josef -- Bird, Adrian -- Schar, Primo -- England -- Nature. 2011 Feb 17;470(7334):419-23. doi: 10.1038/nature09672. Epub 2011 Jan 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21278727" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Chromatin/genetics/metabolism ; CpG Islands/genetics ; DNA Methylation ; DNA Repair ; Embryo, Mammalian/*embryology/enzymology/*metabolism ; Embryonic Development/*genetics ; Epigenesis, Genetic/*genetics ; Fibroblasts/metabolism ; Gene Deletion ; Gene Expression Regulation, Developmental ; Genes, Essential/genetics ; Genes, Lethal/*genetics ; Histones/metabolism ; Mice ; Mice, Knockout ; *Phenotype ; Promoter Regions, Genetic/genetics ; Thymine DNA Glycosylase/deficiency/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Exploratory Analysis, Dynamic Statistical Visualization, and Geographic Information Systems (1992)
    Taylor & Francis
    Details
    Publication Date: 1992-01-01
    Print ISSN: 1050-9844
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Taylor & Francis
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Abstracts (1977)
    Springer
    Details
    Publication Date: 1977-01-01
    Print ISSN: 0364-152X
    Electronic ISSN: 1432-1009
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Assessment Planning and Evaluation of Renewable Energy Resources: an Interactive Computer Assisted Procedure (1982)
    In:  CASI
    Details
    Publication Date: 2014-09-09
    Description: Adaptation and derivation were used to develop a procedure for assessing the availability of renewable energy resources on the landscape while simultaneously accounting for the economic, legal, social, and environmental issues required. Done in a step-by-step fashion, the procedure can be used interactively at the computer terminals. Its application in determining the hydroelectricity, biomass, and windpower in a 40,000 acre study area of Western Massachusetts shows that: (1) three existing dam sites are physically capable of being retrofitted for hydropower; (2) each of three general areas has a mean annual windspeed exceeding 14 mph and is conductive to windpower; and (3) 20% of the total land area consists of prime agricultural biomass while 30% of the area is prime forest biomass land.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Marshall Univ. Proc. of the Natl. Conf. on Energy Resource Management, Vol. 2; p 566-588
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unknown
    Coherent optical data processing and remotely sensed imagery (1969)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: It is shown that an automatic imaging system consisting of a combination of optical and digital computer elements is feasible and has considerable advantages over direct image scanning systems. With such a system, it is possible to process very large quantities of remotely sensed image spectra.
    Keywords: GEOPHYSICS
    Type: NASA-CR-125640 , USGS-IR-NASA-145
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...