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  • 1
    Publikationsdatum: 1991-11-22
    Beschreibung: Intrinsic transcription terminators of prokaryotes are distinguished by a common RNA motif: a stem-loop structure high in guanine and cytosine content, followed by multiple uridine residues. Models explaining intrinsic terminators postulate that the stem-loop sequence is necessary only to form structure. In the tR2 terminator of coliphage lambda, single-nucleotide changes reducing potential RNA stem stability eliminated tR2 activity, and a compensatory change that restored the stem structure restored terminator activity. However, multiple changes in the stem sequence that should have either maintained or increased stability reduced terminator activity. These results suggest that the ability of the stem-loop structure to signal transcription termination depends on sequence specificity and secondary structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheng, S W -- Lynch, E C -- Leason, K R -- Court, D L -- Shapiro, B A -- Friedman, D I -- AI1459-10/AI/NIAID NIH HHS/ -- N01-CO-74101/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Nov 22;254(5035):1205-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1835546" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bacteriophage lambda/*genetics ; Base Sequence ; DNA Mutational Analysis ; Gene Expression Regulation, Viral ; Genes, Viral ; Molecular Sequence Data ; Nucleic Acid Conformation ; RNA, Messenger/genetics ; RNA, Viral/genetics ; *Regulatory Sequences, Nucleic Acid ; Restriction Mapping ; *Terminator Regions, Genetic ; *Transcription, Genetic ; Viral Structural Proteins/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 15 (1969), S. 707-711 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Red blood cell damage and destruction are important problems in the use of artificial valves, heart-lung machines, and other devices which pump or process blood. An experimental study has been made on the mechanism of cell damage. Damage was defined by three types of observations on blood which had been subjected to trauma: (a) release of hemoglobin from cells (hemolysis), (b) morphological changes observed microscopically, and (c) red cell life span studies in rabbits using a Cr51 tagging technique.Three types of physical forces which might be injurious to red cells were studied; shearing stress (of known, constant magnitudes from a concentric cylinder viscometer), pressure variations (from studies in a static pressure cell), and direct impact of solid surfaces (from studies in a device which simulates the seating action of artificial heart valves).The study shows that high shearing stress may be primarily responsible for mechanical cell damage under certain important circumstances. There is a critical shearing stress above which cell damage increases markedly. Much of the cell damage does not appear as an immediate release of hemoglobin. Many cells undergo morphological changes and exhibit shortened average life span in vivo. The morphological changes due to shearing stress are very similar to the changes observed in patients who have hemolytic anemia associated with artificial valves.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2016-03-10
    Beschreibung: A repeating fast radio burst Nature 531, 7593 (2016). doi:10.1038/nature17168 Authors: L. G. Spitler, P. Scholz, J. W. T. Hessels, S. Bogdanov, A. Brazier, F. Camilo, S. Chatterjee, J. M. Cordes, F. Crawford, J. Deneva, R. D. Ferdman, P. C. C. Freire, V. M. Kaspi, P. Lazarus, R. Lynch, E. C. Madsen, M. A. McLaughlin, C. Patel, S. M. Ransom, A. Seymour, I. H. Stairs, B. W. Stappers, J. van Leeuwen & W. W. Zhu Fast radio bursts are millisecond-duration astronomical radio pulses of unknown physical origin that appear to come from extragalactic distances. Previous follow-up observations have failed to find additional bursts at the same dispersion measure (that is, the integrated column density of free electrons between source and telescope) and sky position as the original detections. The apparent non-repeating nature of these bursts has led to the suggestion that they originate in cataclysmic events. Here we report observations of ten additional bursts from the direction of the fast radio burst FRB 121102. These bursts have dispersion measures and sky positions consistent with the original burst. This unambiguously identifies FRB 121102 as repeating and demonstrates that its source survives the energetic events that cause the bursts. Additionally, the bursts from FRB 121102 show a wide range of spectral shapes that appear to be predominantly intrinsic to the source and which vary on timescales of minutes or less. Although there may be multiple physical origins for the population of fast radio bursts, these repeat bursts with high dispersion measure and variable spectra specifically seen from the direction of FRB 121102 support an origin in a young, highly magnetized, extragalactic neutron star.
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Springer Nature
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 1979-12-01
    Print ISSN: 0148-6055
    Digitale ISSN: 1520-8516
    Thema: Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 1969-09-01
    Print ISSN: 0001-1541
    Digitale ISSN: 1547-5905
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Publiziert von Wiley im Namen von American Institute of Chemical Engineers.
    Standort Signatur Erwartet Verfügbarkeit
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