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  • 1
    Electronic Resource
    Electronic Resource
    A bone biopsy procedure (1969)
    Springer
    Calcified tissue international 4 (1969), S. 269-273 
    Details
    ISSN: 1432-0827
    Keywords: Bone-Biopsy ; Histology ; Instruments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé L'intérêt de plus en plus grand manifesté pour les troubles du métabolisme du squelette nécessite en clinique la mise au point de méthodes adéquates pour prélever du matériel osseux. A l'hôpital universitaire d'Utrecht, on se sert actuellement d'un trépan et d'une scie de base. Une description du prélevement, des instruments et de la méthode pour obtenir des coupes nondécalcifiées est présentée.
    Abstract: Zusammenfassung Das zunehmende Interesse an Problemen des Knochenmetabolismus hatte zur Folge, daß geeignete Methoden zur Gewinnung von Knochenbiopsien benötigt wurden. An der Universitätsklinik Utrecht werden jetzt ein Trepan und eine Basensäge benützt. Das Verfahren, die benötigten Instrumente, sowie die Arbeitsweise zur Herstellung von unentkalkten Schliffen werden beschrieben.
    Notes: Abstract The increasing interest in disorders of skeletal metabolism has urged the clinical need for adequate methods to obtain bone material. At the Utrecht University Hospital, a trephine and a base saw are now in use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279130
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  • 2
    Electronic Resource
    Electronic Resource
    Oestrogen binding proteins in bone cell cytosol (1978)
    Springer
    Calcified tissue international 25 (1978), S. 249-254 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Oestrogens ; Oestrogen receptors ; Binding proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Attempts were made to demonstrate the presence of specific oestrogen binding proteins (“receptors”) in bone cells. High speed cytosol preparations of bone were incubated with several concentrations of radioactive oestradiol alone and with radioactive oestradiol in the presence of a specific antioestrogen, Nafoxidine. Separation of bound and free oestradiol was carried out by dextran coated charcoal treatment and by sucrose gradient ultracentrifugation. Several types of bones likely to be oestrogen-sensitive were investigated: human femoral heads, human phalanx, rat and rabbit calvaria, humeri and femora of female rats. In all experiments we were unable to demonstrate the presence of specific oestrogen receptors in bone cell cytosol indicating that the direct effect of oestrogens on bone, if present, is not mediated by specific oestrogen receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010778
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  • 3
    Electronic Resource
    Electronic Resource
    Quantitative-histological comparison of bone biopsies taken from patients with osteoporosis, and primary and secondary hyperparathyroidism (1976)
    Springer
    Calcified tissue international 22 (1976), S. 404-406 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064113
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  • 4
    Electronic Resource
    Electronic Resource
    A quantitative histological study of bone in 30 patients with renal insufficiency (1972)
    Springer
    Calcified tissue international 9 (1972), S. 216-225 
    Details
    ISSN: 1432-0827
    Keywords: Osteodystrophy ; Renal ; Histology ; Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Chez 30 patients, présentant une insuffisance rénale, des biopsies de la crête iliaque sont débitées en coupes non décalcifiées pour réaliser une évaluation morphométrique. Le volume de l'os est normal. On note une augmentation du tissue ostéoide et de la résorption osseuse, ainsi qu'une quantité anormale de tissue fibreux. A l'aide de calcul de corrélation et d'analyse de facteurs, quatre facteurs sont choisis. Ils expriment l'influence de l'hormone parathyroidienne sur le tissue osseux, le degré de minéralisation et le rapport entre le volume osseux et la surface osseuse, le rapport entre tissu osseux et espace mesuré, et la résorption osseuse non active.
    Abstract: Zusammenfassung Bei 30 Patienten mit Niereninsuffizienz wurde aus dem Beckenkamm eine Biopsie entnommen und zu Knochenschliffen für morphometrische Messungen verarbeitet. Das Knochenvolumen was normal. Es fand sich ein vergrößerter Anteil an Osteoidgewebe, eine verstärkte Knochenresorption und eine abnormale Menge an fibrösem Gewebe. Mittels Korrelationsberechnungen und Faktoranalysen wurden 4 Faktoren ermittelt, welche folgende Eigenschaften ausdrückten: erstens den Einfluß des Parathormones auf das Knochengewebe, zweitens den Verkalkungsgrad und das Verhältnis zwischen Knochenvolumen und Knochenoberfl;ache, drittens das Verhältnis zwischen Knochengewebe und Zwischenraum und viertens die inaktive Knochenresorption.
    Notes: Abstract In 30 patients with renal insufficiency, a biopsy specimen was taken from the iliac crest and processed to obtain non-decalcified sections for morphometric evaluation. The bone volume was normal. There was an increased amount of osteoid tissue, increased bone resorption and an abnormal amount of fibrous tissue. With the aid of correlation calculations and factor analysis, four factors were extracted which expressed the influence of parathyroid hormone on bone tissue, the degree of mineralization and the relation between bone volume and bone surface, the relation between bone tissue and measured space, and non-active bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02061960
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  • 5
    Electronic Resource
    Electronic Resource
    Serum calcium, phosphate and alkaline phosphatase and morphometric bone examinations in 30 patients with renal insufficiency (1974)
    Springer
    Calcified tissue international 16 (1974), S. 129-138 
    Details
    ISSN: 1432-0827
    Keywords: Serum ; Calcium ; Phosphate ; Alkaline phosphatase ; Kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract In 30 patients with chronic renal insufficiency (16 non-dialysed and 14 on dialysis) serum calcium, phosphate and alkaline phosphatase were determined and, in a crest biopsy specimen, morphometric determinations of bone qualities were calculated. A positive correlation was established between serum alkaline phosphatase, the osteoblast surface and the active resorption surface in both dialysed and non-dialysed patients. A positive correlation was also established between the osteoblast surface and the active resorption. In the non-dialysed patients a negative correlation was established between serum calcium and the osteoid surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008218
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical use of a parathyroid hormone determination (1976)
    Springer
    Calcified tissue international 22 (1976), S. 412-414 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064115
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  • 7
    Electronic Resource
    Electronic Resource
    Absolute bioavailability of fluoride from disodium monofluorophosphate and enteric-coated sodium fluoride tablets (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 321-326 
    Details
    ISSN: 1432-1041
    Keywords: Key words Sodium fluoride ; Disodium monofluorophosphate; absolute bioavailability ; pharmacokinetics ; elderly population
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: The absolute bioavailability and other pharmacokinetic parameters of two fluoride formulations were investigated in 13 healthy volunteers, aged 61–70 years. Methods: The following formulations were administered, under fasting conditions, in a single-dose three-way cross-over design: tablets of 76 mg disodium monofluoro phosphate (MFP, equivalent to 10.0 mg F− ion), enteric-coated (e.c.) tablets of 25 mg sodium fluoride (NaFor, equivalent of 11.3 mg F− ion), and an isoosmotic aqueous injection solution (4 ml) of 22.1 mg sodium fluoride (NaFiv, equivalent of 10.0 mg F− ion). There was a wash-out period of at least one week between each administration. Blood was sampled before and during a 24-hour period after administration. For F− excretion urine was sampled 48 hours before (baseline) and over the 48 hours after the adminstration. Results: The mean t1/2 values of the three formulations were 8.3, 8.7 and 8.3 h for MFP, NaFor and NaFiv respectively, and were not significant different. Mean Cmax after MFP was significantly higher than after NaFor [344 vs 142 μg⋅l−1]. Mean tmax for MFP was shorter than for NaFor [1.1 vs 4.6 h]. MFP had significantly higher bioavailability [102.8%] than NaFor [64.2%]. Conclusion: The MFP formulation showed higher bioavailability with smaller variation than the NaFor formulation. MFP is preferable, therefore, for fluoride therapy in clinical practice, and changing from NaFor to MFP will require adjustment of the dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050116
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  • 8
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    Absolute bioavailability of fluoride from disodium monofluorophosphate and enteric-coated sodium fluoride tablets (1996)
    Springer
    Details
    Publication Date: 1996-06-03
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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